Results 31 to 40 of about 112,671,011 (290)

Evaluation of Bcl 2 and Ki 67 expression in Chronic Lymphocytic Leukemia .

مجلة كلية الطب, 2013
Background :Chronic lymphocytic leukemia (CLL) is a low-grade B-lineage lymphoid malignancy. Both  Ki-67 which is a large nuclear protein associated with cell proliferation and Bcl-2 which is an anti-apoptotic protein which is associated with ...
Subh S. AL- Mudallal, Huda N. Jasim
doaj   +1 more source

Combining the Telomerase Inhibitor Imetelstat with the BCL-2 Inhibitor Venetoclax Enhances Apoptosis and Improves Survival in Acute Myeloid Leukemia Cellular and Animal Models [PDF]

J Clin Med
Huang F, Rusbuldt J, Luistro L, Colton H, Eid J.   +4 more
europepmc   +2 more sources

Potential mechanisms of resistance to venetoclax and strategies to circumvent it

BMC Cancer, 2017
Background Venetoclax (ABT-199), a first-in-class orally bioavailable BCL-2-selective inhibitor, was recently approved by the FDA for use in patients with 17p-deleted chronic lymphocytic leukemia who have received prior therapy.
Stephen K. Tahir, Morey L. Smith, Paul Hessler, Lisa Roberts Rapp, Kenneth B. Idler, Chang H. Park, Joel D. Leverson, Lloyd T. Lam   +7 more
doaj   +1 more source

Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6 [PDF]

, 2000
Lymphocytes usually differentiate into effector cells within days after antigen exposure, except in germinal centers where terminal differentiation is delayed while somatic hypermutation creates high-affinity antibody mutants. Here we investigate whether
Peakman, LJ, Rajko Reljic (406091), Rajko Reljic, Reljic, R, Fearon, DT, Simon D. Wagner, Luke J. Peakman, Luke J. Peakman (7768292), Fearon, D T, Douglas T. Fearon, Wagner, S D, Wagner, SD, Simon D. Wagner (7633943), Douglas T. Fearon (7768295), Peakman, L J   +14 more
core   +1 more source

Predisposition to Apoptosis in Hepatocellular Carcinoma: From Mechanistic Insights to Therapeutic Strategies

Frontiers in Oncology, 2019
Hepatocellular carcinoma (HCC) ranks among the most rapidly evolving cancers in the Western world. The majority of HCCs develop on the basis of a chronic inflammatory liver damage that predisposes liver cancer development and leads to deregulation of ...
Jens U. Marquardt, Jens U. Marquardt, Frank Edlich, Frank Edlich   +3 more
doaj   +1 more source

Bcl-xL is the only anti-apoptotic Bcl-2 family member necessary for survival during KSHV latent infection.

, 2023
(A) TIME cells were transduced with the indicated sgRNAs and selected as before and were subsequently mock or KSHV infected. Cell viability was measured with a trypan blue assay 48 hpi.
Michael Lagunoff (143637), Lyndsey N. Moore (15447690), Daniel L. Holmes (15447693), Joselyn Landazuri Vinueza (15447696), Anjali Sharma (538603)   +4 more
core   +1 more source

Significance of Bcl-2 and Bcl-6 immunostaining in B-Non Hodgkin's lymphoma

Hematology Reports, 2011
The determination of prognosis for B-Non- Hodgkin’s lymphoma (NHL) is known to be related to the multiple differences in tumor cell biology. Bcl-2 and Bcl-6 are two markers linked to germinal center B cells.
Hanan Mohamed Mahmoud, Yasmin Nabil Elsakhawy   +1 more
doaj   +1 more source

Enhanced Antileukemic Efficacy of Venetoclax-Loaded PEG-PLGA Nanoparticles Against THP-1 Acute Monocytic Leukemia Cells via Suppression of BCL-2 and Pro-Survival Signaling Pathways. [PDF]

Biomedicines
Keni Begendi N, Kaga E.
europepmc   +2 more sources

Evaluation of Bcl-2 as a marker for chronic kidney disease prediction in cats

Frontiers in Veterinary Science, 2023
Chronic kidney disease (CKD) is a frequent condition in elderly cats. Bcl-2 is linked to kidney disease through the processes of apoptosis and fibrosis.
Pattiya Pila, Phongsakorn Chuammitri, Phongsakorn Chuammitri, Prapas Patchanee, Kidsadagon Pringproa, Kakanang Piyarungsri, Kakanang Piyarungsri   +6 more
doaj   +1 more source

Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis

Cell Reports, 2017
Summary: We describe a mechanism by which the anti-apoptotic B cell lymphoma 2 (Bcl-2) protein is downregulated to induce apoptosis. ARTS (Sept4_i2) is a tumor suppressor protein that promotes cell death through specifically antagonizing XIAP (X-linked ...
Natalia Edison, Yael Curtz, Nicole Paland, Dana Mamriev, Nicolas Chorubczyk, Tali Haviv-Reingewertz, Nir Kfir, David Morgenstern, Meital Kupervaser, Juliana Kagan, Hyoung Tae Kim, Sarit Larisch   +11 more
doaj   +1 more source