Results 31 to 40 of about 377,868 (302)
Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis
Cell Reports, 2017 Summary: We describe a mechanism by which the anti-apoptotic B cell lymphoma 2 (Bcl-2) protein is downregulated to induce apoptosis. ARTS (Sept4_i2) is a tumor suppressor protein that promotes cell death through specifically antagonizing XIAP (X-linked ...
Natalia Edison +11 more
doaj +1 more source
Differential dependence on Beclin 1 for the regulation of pro-survival autophagy by Bcl-2 and Bcl-xL in HCT116 colorectal cancer cells. [PDF]
PLoS ONE, 2010 Autophagy is described to be involved in homeostasis, development and disease, both as a survival and a death process. Its involvement in cell death proceeds from interrelationships with the apoptotic pathway.
Muriel Priault +5 more
doaj +1 more source
Análise da correlação entre a expressão da p53 e do bcl-2 com o estadiamento e o prognóstico do adenocarcinoma colorretal [PDF]
, 2005 PURPOSE: To analyze the correlation between p53 and bcl-2 expression and colorectal adenocarcinoma staging and prognosis. METHODS: This was a retrospective series of 125 colorectal adenocarcinoma patients (67 women and 58 men; ages 30-87 years) who ...
Artigiani Neto, Ricardo +5 more
core +3 more sources
BCL-W has a fundamental role in B cell survival and lymphomagenesis. [PDF]
, 2017 Compromised apoptotic signaling is a prerequisite for tumorigenesis. The design of effective therapies for cancer treatment depends on a comprehensive understanding of the mechanisms that govern cell survival.
Annette S. Kim +14 more
core +2 more sources
Neoplasia: An International Journal for Oncology Research, 2007 Head, neck squamous cell carcinomas (HNSCCs) are frequently characterized by chemotherapy, radiation resistance, by overexpression of Bcl-XL, an antiapoptotic member of the Bcl-2 protein family. In this report, we examined whether cell-permeable peptides
Rongxiu Li +5 more
doaj +1 more source
Expression of apoptosis regulating proteins p53 and bcl-2 in psoriasis
Indian Journal of Pathology and Microbiology, 2015 Background: Dysfunctional apoptosis has an important role in the development of several skin diseases. Psoriatic keratinocytes possess an enhanced ability to resist apoptosis, which might be one of the key pathogenetic mechanisms in psoriasis.
Nikhil Moorchung +3 more
doaj +1 more source
Structural insights for selective disruption of Beclin 1 binding to Bcl-2
Communications Biology, 2023 Stimulation of autophagy could provide powerful therapies for multiple diseases, including cancer and neurodegeneration. An attractive drug target for this purpose is Bcl-2, which inhibits autophagy by binding to the Beclin 1 BH3-domain.
Yun-Zu Pan +4 more
doaj +1 more source
The BCL-2 Family Reunion [PDF]
Molecular Cell, 2010 B cell CLL/lymphoma-2 (BCL-2) and its relatives comprise the BCL-2 family of proteins, which were originally characterized with respect to their roles in controlling outer mitochondrial membrane integrity and apoptosis. Current observations expand BCL-2 family function to include numerous cellular pathways.
Chipuk, Jerry E. +4 more
openaire +2 more sources
Cell, 2009 BCL-2 family proteins regulate apoptotic cell death. BCL-2 proteins localize to intracellular membranes such as endoplasmic reticulum and mitochondria, and some family members translocate from the cytoplasm to mitochondria following a cell death stimulus.
Hardwick, J. Marie, Youle, Richard J.
openaire +2 more sources
Effect of Oocyte Vitrification Before and After in Vitro Maturation Towards Bcl-2, Bax and Bcl-2/Bax Ratio Expression [PDF]
, 2016 Objectives: to compare the expression of Bcl-2, Bax and Bcl-2/Bax ratio in cumulus cell and oocyte between vitrified oocyte pre and post in vitro maturation.Materials and Methods: Maturation was operated in medium TC 100 µl for 24 hours.
Aswin, H. (Haryanto) +2 more
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