Results 51 to 60 of about 377,868 (302)
Leishmania donovani induced increase in macrophage Bcl-2 favors parasite survival
Frontiers in Immunology, 2016 Members of the Bcl-2 family are major regulators of apoptosis in mammalian cells and hence infection-induced perturbations in their expression could result into elimination of the parasites or creation of a niche favoring survival. In this investigation,
Rajeev Kumar Pandey +5 more
doaj +1 more source
Molecular Cancer, 2022 Background Chronic lymphocytic leukemia (CLL) results in increased susceptibility to infections. T cell dysfunction is not associated with CLL in all patients; therefore, it is important to identify CLL patients with T cell defects.
Lu Liu +13 more
doaj +1 more source
Locating Herpesvirus Bcl-2 Homologs in the Specificity Landscape of Anti-Apoptotic Bcl-2 Proteins [PDF]
, 2015 Viral homologs of the anti-apoptotic Bcl-2 proteins are highly diverged from their mammalian counterparts, yet they perform overlapping functions by binding and inhibiting BH3 (Bcl-2 homology 3)-motif-containing proteins.
Foight, Glenna W., Keating, Amy E.
core +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Evaluation of Bcl-2 as a marker for chronic kidney disease prediction in cats
Frontiers in Veterinary Science, 2023 Chronic kidney disease (CKD) is a frequent condition in elderly cats. Bcl-2 is linked to kidney disease through the processes of apoptosis and fibrosis.
Pattiya Pila +6 more
doaj +1 more source
The bcl-2 family of proteins [PDF]
British Medical Bulletin, 1997 The bcl-2 family of proteins play an important role in the control of apoptosis. Family members exist which are either pro- or anti-apoptotic and their activity appears to control a checkpoint between signals from the cell surface and activation of the ICE-family of proteases.
openaire +2 more sources
The simultaneous effect of valproic acid and gamma radiation on telomerase activity and bax and Bcl-2 protein levels in MCF-7 breast cancer cell line [PDF]
, 2015 Background: Breast cancer is one of the most prevalent types of cancer. Factors such as ionizing radiation and chemotherapeutic agents can trigger apoptosis and cancer cell death.
Asadi, J. +3 more
core +1 more source
FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
Cancer Management and Research, 2018 Bibi Kulsoom,1 Tahir Sultan Shamsi,1 Nasir Ali Afsar,2,3 Zahida Memon,4 Nikhat Ahmed,4 Syed Nazrul Hasnain5 1National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan; 2Jinnah Medical and Dental College, Karachi, Pakistan ...
Kulsoom B +5 more
doaj
Apoptosis regulator BCL-2 [PDF]
, 2013 Apoptosis (programmed cell death) is required for the removal of infected, damaged or unwanted cells. Inadequate cell death is a major contributing factor to tumorigenesis, while excess cell death contributes to neurodegeneration and autoimmune diseases ...
Hussar, Piret +2 more
core +3 more sources