Results 41 to 50 of about 112,671,011 (290)
Differential dependence on Beclin 1 for the regulation of pro-survival autophagy by Bcl-2 and Bcl-xL in HCT116 colorectal cancer cells. [PDF]
PLoS ONE, 2010 Autophagy is described to be involved in homeostasis, development and disease, both as a survival and a death process. Its involvement in cell death proceeds from interrelationships with the apoptotic pathway.
Muriel Priault +5 more
doaj +1 more source
Annals of Medicine, 2023 Background Multiple myeloma (MM) is an incurable malignancy. Venetoclax (VEN) shows a meaningful effect in MM patients who are relapsed or refractory (RR) to previous standard therapies.Objective This study aimed to assess the efficacy and safety of VEN ...
Wei He, Fang He, Huixian Hu
doaj +1 more source
Structural insights for selective disruption of Beclin 1 binding to Bcl-2
Communications Biology, 2023 Stimulation of autophagy could provide powerful therapies for multiple diseases, including cancer and neurodegeneration. An attractive drug target for this purpose is Bcl-2, which inhibits autophagy by binding to the Beclin 1 BH3-domain.
Yun-Zu Pan +4 more
doaj +1 more source
Bcl-2 expression in rectal cancer Expressão da proteína bcl-2 no câncer de reto
Arquivos de Gastroenterologia, 2006 BACKGROUD: Proteins involved in apoptosis process seem to play an important role in colorectal carcinogenesis AIM: To determine the prevalence of bcl-2 protein immunohistochemical expression and its relation with clinical and histopathological variables ...
Paulo C. Contu +2 more
doaj +1 more source
Cells, 2020 The dynamic interplay between pro-death and pro-survival Bcl-2 family proteins is responsible for a cell’s fate. Due to the recognized relevance of this family in cancer progression and response to therapy, different efforts have made in recent years in ...
Simona D’Aguanno, Donatella Del Bufalo
doaj +1 more source
Killing of Sarcoma Cells by Proapoptotic Bcl-XS: Role of the BH3 Domain and Regulation by Bcl-XL
Neoplasia: An International Journal for Oncology Research, 2001 Kaposi's sarcoma (KS) is the most common tumor affecting AIDS patients with over 20% of these patients afflicted by this disease. Previous studies have demonstrated that KS tumor cells predominantly express the prosurvival protein Bcl-XL compared with ...
Raj. S. Mitra +6 more
doaj +1 more source
Selective induction of cell death in melanoma cell lines through targeting of Mcl-1 and A1. [PDF]
, 2012 Melanoma is an often fatal form of skin cancer which is remarkably resistant against radio- and chemotherapy. Even new strategies that target RAS/RAF signaling and display unprecedented efficacy are characterized by resistance mechanisms.
Berking, Carola +18 more
core +2 more sources
Bad expression influences time to androgen escape in prostate cancer [PDF]
, 2007 <b>OBJECTIVE</b>: To assess the role of selected downstream Bcl-2 family members (Bad, Bax, Bcl-2 and Bcl-xL) in the development of androgen-independent prostate cancer (AIPC), as androgen-deprivation therapy is the treatment of choice in ...
Teo, K. +4 more
core +1 more source
Leishmania donovani induced increase in macrophage Bcl-2 favors parasite survival
Frontiers in Immunology, 2016 Members of the Bcl-2 family are major regulators of apoptosis in mammalian cells and hence infection-induced perturbations in their expression could result into elimination of the parasites or creation of a niche favoring survival. In this investigation,
Rajeev Kumar Pandey +5 more
doaj +1 more source
Roles of Bcl-3 in the pathogenesis of murine type 1 diabetes [PDF]
, 2010 OBJECTIVE: It has long been recognized that autoimmunity is often associated with immunodeficiency. The mechanism underlying this paradox is not well understood.
Ruaidhri J. Carmody +9 more
core +1 more source