Results 41 to 50 of about 17,898,482 (301)

BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals

, 2022
BCL-2 family proteins regulate the mitochondrial apoptotic pathway. BOK a multidomain BCL-2 family protein is generally believed to be an adaptor protein similar to BAK and BAX regulating the mitochondrial permeability transition during apoptosis.
Fiona Brown (1432693), Andrew Kueh (12998319), Daniel Bachmann (10216680), Rob Ramsay (12998322), Jason Glab (9475100), Thomas Kaufmann (509918), Francine Ke (12998310), Lorraine O'Reilly (12998313), Lahiru Gangoda (9498728), Tatiana Rabachini (177169), Suresh Mathivanan (9487679), Andrew Wei (410691), Zhipeng Cao (9491657), Joseph Menassa (9482459), Brian Smith (9487481), Sanjay Shahi (9479723), Cody Allison (12998316), Yuniel Fernandez-Marrero (12998307), Hamsa Puthalakath (9481346), Christina Nedeva (11406338), Samara Naim (12998304), Tao Nelson (9475148), Rahul Srivastava (9474350), Marcel Doerflinger (10829874), Laura Murray-Rust (9478424)   +24 more
core   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Combinatorial BCL2/BCL2L1 expression predicts clinical response to ruxolitinib in myelofibrosis

Biomarker Research
Myelofibrosis is characterized by aberrant JAK/STAT signaling, with approved therapy including the JAK inhibitor ruxolitinib. Preclinical evidence implicates BCL-2 family proteins in MF pathogenesis and therapeutic response.
Giacomo Coltro, Viola Videschi, Francesca Gesullo, Federica Violi, Manjola Balliu, Alessandro M. Vannucchi, Paola Guglielmelli   +6 more
doaj   +1 more source

IGF-I protects cortical neurons against ceramide-induced apoptosis via activation of the PI-3K/Akt and ERK pathways; is this protection independent of CREB and Bcl-2?

, 2005
Current understanding of IGF-I-mediated neuroprotection implies the activation of phosphatidylinositol-3-kinase (PI-3K), which leads to the activation of Akt/Protein Kinase B.
Brugg, B., Arbez, N., Willaime-Morawek, S., Mariani, J.   +3 more
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

A surface groove essential for viral bcl-2 function during chronic infection in vivo. [PDF]

PLoS Pathogens, 2005
Antiapoptotic Bcl-2 family proteins inhibit apoptosis in cultured cells by binding BH3 domains of proapoptotic Bcl-2 family members via a hydrophobic BH3 binding groove on the protein surface.
Joy Loh, Qiulong Huang, Andrew M Petros, David Nettesheim, Linda F van Dyk, Lucia Labrada, Samuel H Speck, Beth Levine, Edward T Olejniczak, Herbert W Virgin   +9 more
doaj   +2 more sources

Leishmania donovani induced increase in macrophage Bcl-2 favors parasite survival

Frontiers in Immunology, 2016
Members of the Bcl-2 family are major regulators of apoptosis in mammalian cells and hence infection-induced perturbations in their expression could result into elimination of the parasites or creation of a niche favoring survival. In this investigation,
Rajeev Kumar Pandey, Sanjana Mehrotra, Smriti Sharma, Ramachandra Subbaraya Gudde, Shyam Sundar, Chandrima Shaha   +5 more
doaj   +1 more source

BCL-2 expression promotes immunosuppression in chronic lymphocytic leukemia by enhancing regulatory T cell differentiation and cytotoxic T cell exhaustion

Molecular Cancer, 2022
Background Chronic lymphocytic leukemia (CLL) results in increased susceptibility to infections. T cell dysfunction is not associated with CLL in all patients; therefore, it is important to identify CLL patients with T cell defects.
Lu Liu, Xianfeng Cheng, Hui Yang, Senlin Lian, Yuegen Jiang, Jinhua Liang, Xiao Chen, Suo Mo, Yu Shi, Sishu Zhao, Jianyong Li, Runqiu Jiang, Dong-Hua Yang, Yujie Wu   +13 more
doaj   +1 more source

The bcl-2 family of proteins [PDF]

British Medical Bulletin, 1997
The bcl-2 family of proteins play an important role in the control of apoptosis. Family members exist which are either pro- or anti-apoptotic and their activity appears to control a checkpoint between signals from the cell surface and activation of the ICE-family of proteases.
openaire   +2 more sources