Results 21 to 30 of about 24,682,597 (289)
Bcl-xL deamidation in oncogenic tyrosine kinase signalling
, 2023 I have been interested in the molecular mechanisms of Haematopoietic malignant diseases such as leukaemia and lymphoma, especially those involving oncogenic tyrosine kinases. About 30 of the 90 tyrosine kinases in the human genome have been implicated in
Rui Zhao (43391)
core +7 more sources
Significance of Bcl-2 and Bcl-6 immunostaining in B-Non Hodgkin's lymphoma
Hematology Reports, 2011 The determination of prognosis for B-Non- Hodgkin’s lymphoma (NHL) is known to be related to the multiple differences in tumor cell biology. Bcl-2 and Bcl-6 are two markers linked to germinal center B cells.
Hanan Mohamed Mahmoud +1 more
doaj +1 more source
Frontiers in Oncology, 2019 Hepatocellular carcinoma (HCC) ranks among the most rapidly evolving cancers in the Western world. The majority of HCCs develop on the basis of a chronic inflammatory liver damage that predisposes liver cancer development and leads to deregulation of ...
Jens U. Marquardt +3 more
doaj +1 more source
Oncogene, 1998 Bcl-2 family proteins serve as critical regulators of pathways involved in apoptosis, acting to either inhibit or promote cell death. Altered expression of these proteins occurs commonly in human cancers, contributing to neoplastic cell expansion by suppressing programmed cell death and extending tumor cell life span. Moreover, because chemotherapeutic
openaire +2 more sources
Killing of Sarcoma Cells by Proapoptotic Bcl-XS: Role of the BH3 Domain and Regulation by Bcl-XL
Neoplasia: An International Journal for Oncology Research, 2001 Kaposi's sarcoma (KS) is the most common tumor affecting AIDS patients with over 20% of these patients afflicted by this disease. Previous studies have demonstrated that KS tumor cells predominantly express the prosurvival protein Bcl-XL compared with ...
Raj. S. Mitra +6 more
doaj +1 more source
, 2023 (A) TIME cells were transduced with the indicated sgRNAs and selected as before and were subsequently mock or KSHV infected. Cell viability was measured with a trypan blue assay 48 hpi.
Michael Lagunoff (143637) +4 more
core +1 more source
Roles of Bcl-3 in the pathogenesis of murine type 1 diabetes [PDF]
, 2010 OBJECTIVE: It has long been recognized that autoimmunity is often associated with immunodeficiency. The mechanism underlying this paradox is not well understood.
Ruaidhri J. Carmody +9 more
core +1 more source
Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis
Cell Reports, 2017 Summary: We describe a mechanism by which the anti-apoptotic B cell lymphoma 2 (Bcl-2) protein is downregulated to induce apoptosis. ARTS (Sept4_i2) is a tumor suppressor protein that promotes cell death through specifically antagonizing XIAP (X-linked ...
Natalia Edison +11 more
doaj +1 more source
Expression of apoptosis regulating proteins p53 and bcl-2 in psoriasis
Indian Journal of Pathology and Microbiology, 2015 Background: Dysfunctional apoptosis has an important role in the development of several skin diseases. Psoriatic keratinocytes possess an enhanced ability to resist apoptosis, which might be one of the key pathogenetic mechanisms in psoriasis.
Nikhil Moorchung +3 more
doaj +1 more source
Bcl-2-Ome - a database and interactive web service for dissecting the Bcl-2 interactome.
, 2017 Hantusch A, Brunner T, Frickey T, Rehm M.Bcl-2-Ome - a database and interactive web service for dissecting the Bcl-2 interactome. Cell death & differentiation.
Markus Rehm (7899308) +3 more
core +2 more sources