Results 11 to 20 of about 239,737 (256)
Evaluation of Bcl 2 and Ki 67 expression in Chronic Lymphocytic Leukemia .
مجلة كلية الطب, 2013 Background :Chronic lymphocytic leukemia (CLL) is a low-grade B-lineage lymphoid malignancy. Both Ki-67 which is a large nuclear protein associated with cell proliferation and Bcl-2 which is an anti-apoptotic protein which is associated with ...
Subh S. AL- Mudallal, Huda N. Jasim
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Beyond cell death - antiapoptotic Bcl-2 proteins regulate migration and invasion of colorectal cancer cells in vitro. [PDF]
PLoS ONE, 2013 Migration and invasion of malignant cells are prerequisites for cancer progression and metastasis. The Bcl-2 family of proteins consists of about 25 members and has been extensively studied in the context of apoptosis.
Bruno Christian Koehler +9 more
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Potential mechanisms of resistance to venetoclax and strategies to circumvent it
BMC Cancer, 2017 Background Venetoclax (ABT-199), a first-in-class orally bioavailable BCL-2-selective inhibitor, was recently approved by the FDA for use in patients with 17p-deleted chronic lymphocytic leukemia who have received prior therapy.
Stephen K. Tahir +7 more
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Cells, 2020 The dynamic interplay between pro-death and pro-survival Bcl-2 family proteins is responsible for a cell’s fate. Due to the recognized relevance of this family in cancer progression and response to therapy, different efforts have made in recent years in ...
Simona D’Aguanno, Donatella Del Bufalo
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Significance of Bcl-2 and Bcl-6 immunostaining in B-Non Hodgkin's lymphoma
Hematology Reports, 2011 The determination of prognosis for B-Non- Hodgkin’s lymphoma (NHL) is known to be related to the multiple differences in tumor cell biology. Bcl-2 and Bcl-6 are two markers linked to germinal center B cells.
Hanan Mohamed Mahmoud +1 more
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Frontiers in Oncology, 2019 Hepatocellular carcinoma (HCC) ranks among the most rapidly evolving cancers in the Western world. The majority of HCCs develop on the basis of a chronic inflammatory liver damage that predisposes liver cancer development and leads to deregulation of ...
Jens U. Marquardt +3 more
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Oncogene, 1998 Bcl-2 family proteins serve as critical regulators of pathways involved in apoptosis, acting to either inhibit or promote cell death. Altered expression of these proteins occurs commonly in human cancers, contributing to neoplastic cell expansion by suppressing programmed cell death and extending tumor cell life span. Moreover, because chemotherapeutic
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Killing of Sarcoma Cells by Proapoptotic Bcl-XS: Role of the BH3 Domain and Regulation by Bcl-XL
Neoplasia: An International Journal for Oncology Research, 2001 Kaposi's sarcoma (KS) is the most common tumor affecting AIDS patients with over 20% of these patients afflicted by this disease. Previous studies have demonstrated that KS tumor cells predominantly express the prosurvival protein Bcl-XL compared with ...
Raj. S. Mitra +6 more
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Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis
Cell Reports, 2017 Summary: We describe a mechanism by which the anti-apoptotic B cell lymphoma 2 (Bcl-2) protein is downregulated to induce apoptosis. ARTS (Sept4_i2) is a tumor suppressor protein that promotes cell death through specifically antagonizing XIAP (X-linked ...
Natalia Edison +11 more
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Expression of apoptosis regulating proteins p53 and bcl-2 in psoriasis
Indian Journal of Pathology and Microbiology, 2015 Background: Dysfunctional apoptosis has an important role in the development of several skin diseases. Psoriatic keratinocytes possess an enhanced ability to resist apoptosis, which might be one of the key pathogenetic mechanisms in psoriasis.
Nikhil Moorchung +3 more
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