Results 11 to 20 of about 112,671,011 (290)

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl-2 and Mcl-1 blockade in preclinical glioblastoma models. [PDF]

FEBS Open Bio
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Zhao K, Meyer L, Braun M, Otte K, Bitter C, Pawlik M, Raifer H, Helmprobst F, Pagenstecher A, Urban H, Burger MC, Ronellenfitsch MW, Steinbach JP, Jedelská J, Bagheri S, Yousefi BH, Di Fazio P, Luster M, Mahnken AH, Neubauer A, Burchert A, Nimsky C, Bartsch JW, Rusch T.   +23 more
europepmc   +4 more sources

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance [PDF]

Advanced Science
BCL‐2 is an anti‐apoptotic protein frequently upregulated in cancer, enabling cell survival despite oncogenic stress. This BCL‐2 dependence sensitizes tumor cells to venetoclax, an FDA‐approved drug used against chronic lymphocytic leukemia.
Jonas Aufdermauer, Ian deRidder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
doaj   +2 more sources

Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity

Nature Communications, 2023
Mitochondrial apoptosis is strictly controlled by BCL-2 family proteins through a subtle network of protein interactions. The tumor suppressor protein p53 triggers transcription-independent apoptosis through direct interactions with BCL-2 family proteins,
Hudie Wei, Haolan Wang, Genxin Wang, Lingzhi Qu, Longying Jiang, Shuyan Dai, Xiaojuan Chen, Ye Zhang, Zhuchu Chen, Youjun Li, Ming Guo, Yongheng Chen   +11 more
doaj   +2 more sources

From Platelet Toxicity to Precision Targeting: Evolving Strategies to Overcome Thrombocytopenia in BCL‐2/BCL‐XL Inhibition [PDF]

Health Science Reports
Background Simultaneous blockade of the anti‐apoptotic proteins BCL‐2 and BCL‐XL has been shown to be efficacious in preclinical and clinical trials for tumors that are co‐dependent on their survival pathways, although clinical development has been ...
Md Mohiuddin
doaj   +2 more sources

Bax, Bcl-2, and Bax/Bcl-2 as prognostic markers in acute myeloid leukemia: are we ready for Bcl-2-directed therapy?

Cancer Management and Research, 2018
Bibi Kulsoom,1 Tahir Sultan Shamsi,1 Nasir Ali Afsar,2,3 Zahida Memon,4 Nikhat Ahmed,4 Syed Nazrul Hasnain5 1National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan; 2Jinnah Medical and Dental College, Karachi, Pakistan ...
Kulsoom B, Shamsi TS, Afsar NA, Memon Z, Ahmed N, Hasnain SN   +5 more
doaj   +1 more source

Glutathione and Bcl-2 targeting facilitates elimination by chemoradiotherapy of human A375 melanoma xenografts overexpressing bcl-xl, bcl-2, and mcl-1 [PDF]

Journal of Translational Medicine, 2012
Background Bcl-2 is believed to contribute to melanoma chemoresistance. However, expression of Bcl-2 proteins may be different among melanomas. Thus correlations among expression of Bcl-2-related proteins and in vivo melanoma progression, and resistance ...
Mena Salvador, Rodriguez María L, Ortega Angel, Priego Sonia, Obrador Elena, Asensi Miguel, Petschen Ignacio, Cerdá Miguel, Brown Bob D, Estrela José M   +9 more
doaj   +2 more sources

Immunohistochemical Expression of M30, BCL-2, BAX, and Ki-67 in Pancreatic Ductal Adenocarcinoma: Association with Clinicopathological Features. [PDF]

Diagnostics (Basel)
Demirciler Yavaş B, Yılmaz S.
europepmc   +2 more sources

Rational structure-guided identification of a Bcl-2-targeting peptide with antiproliferative effects on colorectal cancer cells [PDF]

J Enzyme Inhib Med Chem
Jin X, Yang S, Wang Q, Chen S, Wang Y, Yang Y.   +5 more
europepmc   +4 more sources

Gudan Wan attenuates metabolic dysfunction-associated steatohepatitis by modulating autophagy and the Bcl-2/Caspase-3/Caspase-8 apoptotic axis. [PDF]

Front Cell Dev Biol
Han S, Li Q, Ding Z, Yang H, Du D, Zhou Q, Yu J, Yang X.   +7 more
europepmc   +3 more sources

Revealing the Binding Mechanism of Gossypol on Bcl‑2 via Funnel Metadynamics Simulations [PDF]

ACS Omega
Tao Zhu, Sheng He, Meng Luo, Wei Wang
doaj   +2 more sources