Results 81 to 90 of about 17,898,482 (301)
Bcl-xL deamidation in oncogenic tyrosine kinase signalling
, 2023 I have been interested in the molecular mechanisms of Haematopoietic malignant diseases such as leukaemia and lymphoma, especially those involving oncogenic tyrosine kinases. About 30 of the 90 tyrosine kinases in the human genome have been implicated in
Rui Zhao (43391)
core +1 more source
Advanced Science, EarlyView.NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang +12 more
wiley +1 more source
Silencing Bcl-2 Expression in Epithelial Cancer Cells Using “Smart” Particles
Journal of Functional Biomaterials, 2014 Short interfering RNA (siRNA) targeted against anti-apoptotic Bcl-2 protein proved to knockdown its expression and trigger cancer cell death. We used degradable, pH-sensitive, comb-like [P(EAA-co-BMA)-b-PNASI-g-P(HMA-co-TMAEMA)] polymer to condense anti ...
Yen-Ling Lin +4 more
doaj +1 more source
, 2011 Protein obtained from cell lysates (100 μg) of WSU-FSCCL cells were separated on a 12% SDS-PAGE. Proteins were immunoblotted using specific primary antibodies to Bcl-2, Bcl-X, Mcl-1, Bax, Bak, and Bad. Primary antibodies were diluted in 2% BSA. Secondary
Ramzi M Mohammad (88292) +6 more
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BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival [PDF]
, 2019 Malignant melanoma is one of the most difficult cancers to treat due to its resistance to chemotherapy. Despite recent successes with BRAF inhibitors and immune checkpoint inhibitors, many patients do not respond or become resistant to these drugs. Hence,
Herold, MJ +59 more
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Advanced Science, EarlyView.This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang +14 more
wiley +1 more source
Haematologica, 2020 The BCL-2-specific inhibitor, ABT-199 (venetoclax) has exhibited remarkable clinical activity in nearly all cases of chronic lymphocytic leukemia. In contrast, responses are usually much less in diffuse large B-cell lymphoma (DLBCL), despite high level ...
Victoria M. Smith +11 more
doaj +1 more source
Bcl-2-Ome - a database and interactive web service for dissecting the Bcl-2 interactome.
, 2017 Hantusch A, Brunner T, Frickey T, Rehm M.Bcl-2-Ome - a database and interactive web service for dissecting the Bcl-2 interactome. Cell death & differentiation.
Markus Rehm (7899308) +3 more
core
Bcl-2 concentrations in SNU-1 cells after treatment with particles.
, 2021 Cells were treated with 100 μg/mL of 50–5000 nm PS particles for 4 h. Human Bcl-2 concentrations in the cellular lysates were determined and normalized to protein content.
Amrita Banerjee (382658) +2 more
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CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction
Advanced Science, EarlyView.CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma +12 more
wiley +1 more source