Results 81 to 90 of about 377,868 (302)

Somatic hypermutation of IGVH genes and aberrant somatic hypermutation in follicular lymphoma without BCL-2 gene rearrangement and expression

Haematologica, 2008
Background Follicular lymphoma is characterized by the t(14;18) translocation resulting in constitutive expression of BCL-2 protein; however approximately 10–15% of follicular lymphomas do not express BCL-2 protein, and a small fraction of these cases ...
Éva Gagyi, Zsófia Balogh, Csaba Bödör, Botond Timár, Lilla Reiniger, Linda Deák, Judit Csomor, Balázs Csernus, Ágota Szepesi, András Matolcsy   +9 more
doaj   +1 more source

Computational study of the mechanism of Bcl-2 apoptotic switch

, 2012
Programmed cell death - apoptosis is one of the most studied biological phenomenon of recent years. Apoptotic regulatory network contains several significant control points, including probably the most important one - Bcl--2 apoptotic switch.
Adams, Albeck, Angeli, Angeli, Antonsson, Bagci, Barkai, Bluthgen, Brunelle, Chen, Chen, Cheng, Chipuk, Cory, Cui, Delhalle, Desagher, Dlugosz, Duke, Dussmann, Eissing, Eissing, Elmore, Fell, Ferrell, Ferrell, Ferrell, Goldstein, Gross, Gulbins, Harrington, Hellwig, Hua, Huang, Hucka, Jozef Uličný, Kholodenko, Kim, Kinnally, A.B., Kitano, Kroemer, Kroemer, Kroemer, Kuwana, Kuwana, Kuwana, Leber, Legewie, Legewie, Letai, Luo, Luthi, M.S.J, Madesh, Martinez-Caballero, Mayer, Oliver, Ott, Peixoto, Ramsey, Rehm, Rehm, Ruffolo, Spencer, Strasser, Sun, Tait, Tan, Terrones, Tomáš Tokár, Tsujimoto, Tyson, Valentijn, Vaux, von Ahsen, Walensky, Willis, Willis   +76 more
core   +1 more source

GSH‐Responsive Nanoparticles Enhance Hepatocellular Carcinoma Immunotherapy Through Synergistic Effects of Cuproptosis and PI3K Inhibitor Combination

Advanced Science, EarlyView.
ABSTRACT Cuproptosis, an emerging form of programmed cell death, is capable of inducing mitochondrial dysfunction. Moreover, the PI3K‐AKT‐mTOR signaling pathway contributes to tumor cell progression by reprogramming mitochondrial morphology and function.
Lei Wu, Jintong Na, Xiyu Liu, Dongsheng Tang, Zhungang Yang, Zheng Cao, Xinyue He, Haihua Xiao, Liping Zhong, Yuan Liao, Yongxiang Zhao   +10 more
wiley   +1 more source

MDA-7/IL-24 induces Bcl-2 denitrosylation and ubiquitin-degradation involved in cancer cell apoptosis.

PLoS ONE, 2012
MDA-7/IL-24 was involved in the specific cancer apoptosis through suppression of Bcl-2 expression, which is a key apoptosis regulatory protein of the mitochondrial death pathway. However, the underlying mechanisms of this regulation are unclear.
Hui Tian, Jing Wang, BaoFu Zhang, JieHui Di, FeiFei Chen, HuiZhong Li, LianTao Li, DongSheng Pei, JunNian Zheng   +8 more
doaj   +1 more source

inhibits apoptosis in THP-1 cells by downregulation of Bad and Bak and upregulation of Mcl-1 gene expression [PDF]

, 2006
Background: Virulent Mycobacterium leprae interfere with host defense mechanisms such as cytokine activation and apoptosis. The mitochondrial pathway of apoptosis is regulated by the Bcl-2 family of proteins.
Ashraf, Mussarat, Hasan, Zahra, Hussain, Rabia, Tayyebi, Ali   +3 more
core   +3 more sources

ELABELA Targets Mitochondria to Modulate Heart Development

Advanced Science, EarlyView.
The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang, Qingjie Wang, Zhikang Xu, Shuang Zhou, Yue Zhou, Junjie Yang, Lingfeng Tong, Zhuo Meng, Mei Yang, Wen Zhao, Tie Yang, Hualin Wang, Jun Zhang, Rubin Tan, Lei Wang, Yuqiang Huang, Bin Zhou, Sun Chen, Bing Zhang, Jinxiang Yuan, Jianyuan Zhao, Alex F. Chen, Kun Sun   +22 more
wiley   +1 more source

Suppression of apoptosis in perfusion culture of Myeloma NS0 cells enhances cell growth but reduces antibody productivity [PDF]

, 2004
A spin filter perfusion systems was used to achieve a high cell density culture for two NS0 cell lines in 2 litres bioreactors. One cell line is transfected with the bcl-2 gene (NS0 Bcl-2) encodes the 'anti-apoptotic' human Bcl-2 protein and the other ...
Al-Rubeai, Mohamed, Tey, Beng Ti
core   +1 more source

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

Silencing Bcl-2 Expression in Epithelial Cancer Cells Using “Smart” Particles

Journal of Functional Biomaterials, 2014
Short interfering RNA (siRNA) targeted against anti-apoptotic Bcl-2 protein proved to knockdown its expression and trigger cancer cell death. We used degradable, pH-sensitive, comb-like [P(EAA-co-BMA)-b-PNASI-g-P(HMA-co-TMAEMA)] polymer to condense anti ...
Yen-Ling Lin, Guohua Jiang, Zhaocheng Zhang, Jacques E. Nör, Mohamed E. H. ElSayed   +4 more
doaj   +1 more source

Inhibition of glucocorticoid-induced apoptosis by targeting splice variants of \u3ci\u3eBIM\u3c/i\u3e mRNA with small interfering RNA and short hairpin RNA. [PDF]

, 2004
Glucocorticoids (GCs) induce apoptosis in lymphocytes and are effective agents for the treatment of leukemia. The activated glucocorticoid receptor (GR) initiates a transcriptional program leading to caspase activation and cell death, but the critical ...
Abrams, Marc T., Robertson, Noreen M., Wickstrom, Eric, Yoon, Kyonggeun   +3 more
core   +1 more source