Results 91 to 100 of about 17,898,482 (301)

Combined transfection of Bcl-2 siRNA and miR-15a oligonucleotides enhanced methotrexate-induced apoptosis in Raji cells

Cancer Biology & Medicine, 2013
Objective:B-cell lymphoma 2 (Bcl-2) is an important member of the Bcl-2 family of proteins that regulate the induction of apoptosis. This study aims to investigate whether Bcl-2 small interfering RNA (siRNA) combined with miR-15a oligonucleotides (ODN ...
Li Ding, Xiao-Mao Hu, Hong Wu, Ge-Xiu Liu, Yang-Jun Gao, Dong-Mei He, Yuan Zhang   +6 more
doaj   +1 more source

Brown Adipocyte Sheets Alleviate Myocardial Ischemia–Reperfusion Injury Through NRG4–ErbB4–Dependent Ferroptosis Inhibition

Advanced Science, EarlyView.
Brown adipocyte sheets are engineered to protect the heart against myocardial ischemia–reperfusion injury by restraining ferroptosis. Upon transplantation onto the cardiac surface, they improve cardiac function, limit infarction and fibrosis, and enhance angiogenesis.
Lifu Sun, Yuting Liu, Jingbo Zhang, Takuji Kawamura, Junjun Li, Li Liu, Shigeru Miyagawa   +6 more
wiley   +1 more source

Familija Bcl 2 proteina kod malignih bolesti [PDF]

Vojnosanitetski Pregled, 2004
Brajušković Goran R., Milić-Škaro Anđelija, Cerović Snežana J., Marjanović Slobodan A., Ušaj-Knežević Slavica, Čizmić Milica, Dimitrijević Jovan   +6 more
doaj   +1 more source

BCL-XL is an actionable target for treatment of malignant pleural mesothelioma

, 2020
© 2020, The Author(s). Despite having one of the lowest survival rates of all cancers, there have been no new approved treatments for malignant pleural mesothelioma (MPM) in over a decade.
Surein Arulananda (9474620), Jonathan Cebon (9483446), Laura Jenkins (9488798), M Evangelista (9750761), RJJ O’Donoghue (9750773), NS Steinohrt (9750767), Thomas John (436356), Megan O'Brien (9498854), TJ Harris (9750764), B Thapa (9551243), Walter Fairlie (9481229), Xia Li (9484709), T Leong (9750776), John Mariadason (9487703), M Walkiewicz (9750770), Erinna Lee (9484976), Ashleigh Poh (9491243), David Williams (9477638)   +17 more
core   +1 more source

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

Exploring the Conformational Space of Bcl-2 Protein Variants: Dynamic Contributions of the Flexible Loop Domain and Transmembrane Region

Molecules, 2019
Members of the Bcl-2 protein family regulate apoptosis through interactions with several proteins. A critical intrinsically disordered region (IDR) present in some members of the Bcl-2 family is essential for their function.
Luis A. Caro-Gómez, Jorge L. Rosas-Trigueros, Edgar Mixcoha, José L. Vique-Sánchez, Humberto Gasperin-Sánchez, Claudia G. Benítez-Cardoza, Absalom Zamorano-Carillo   +6 more
doaj   +1 more source

Kelidonin hatása a Bcl-2 antiapoptotikus fehérje expressziójára humán uveális melanóma sejtvonalakon

, 2015
Itt bemutatott kísérleteinkben a benzofenantridinvázas alkaloidok családjába tartozó kelidonin hatását vizsgáltuk a Bcl-2 antiapoptotikus fehérje expressziós szintjére OCM-1 és OCM-3 humán uveális melanóma sejtvonalakon.
Szabó, Ágnes
core  

BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals

, 2019
BCL-2 family proteins regulate the mitochondrial apoptotic pathway. BOK a multidomain BCL-2 family protein is generally believed to be an adaptor protein similar to BAK and BAX regulating the mitochondrial permeability transition during apoptosis.
Fiona Brown (1432693), Daniel Bachmann (10216680), Rob Ramsay (12998322), Jason Glab (9475100), Thomas Kaufmann (509918), Francine Ke (12998310), Lorraine O'Reilly (12998313), Andrew Kueh (20405420), Lahiru Gangoda (9498728), Tatiana Rabachini (177169), Suresh Mathivanan (9487679), Andrew Wei (410691), Zhipeng Cao (9491657), Joseph Menassa (9482459), Brian Smith (9487481), Sanjay Shahi (9479723), Cody Allison (12998316), Yuniel Fernandez-Marrero (12998307), Hamsa Puthalakath (9481346), Christina Nedeva (11406338), Samara Naim (12998304), Tao Nelson (9475148), Rahul Srivastava (9474350), Marcel Doerflinger (10829874), Laura Murray-Rust (9478424)   +24 more
core   +1 more source

Triple‐Negative Breast Cancer Cells Utilize IL8 and CXCL1 to Suppress NK Cells’ Function and Facilitate Cancer Metastasis

Advanced Science, EarlyView.
Triple‐negative breast cancer (TNBC) cells evade natural killer (NK) cell immunity by secreting IL8 and CXCL1. These chemokines suppress NK cells’ function via CXCR1/2 and enhance cancer cells’ survival through PD‐L1 upregulation and BCL‐2 anti‐apoptotic signaling.
Mingheng Yuan, Hongmei Yang, Renfei Wu, Meng Hao, Xiangpeng Chu, Chuxia Deng, Kathy Qian Luo   +6 more
wiley   +1 more source

Semi‐Mechanistic PK/PD Modeling of Platelets and Spleen Volume With Navitoclax in Combination With Ruxolitinib in Patients With Myelofibrosis

CPT: Pharmacometrics & Systems Pharmacology
Navitoclax, an oral small molecule BCL‐XL/BCL‐2 inhibitor evaluated in myelofibrosis, was assessed through integrated PK/PD modeling to guide starting dose and dose‐reduction decisions when combined with ruxolitinib.
Akshanth R. Polepally, Aline Goebel, Maulik Patel, Carla Biesdorf, Jalaja Potluri, Rajeev M. Menon, Sven Mensing, Benjamin Engelhardt   +7 more
doaj   +1 more source