Results 91 to 100 of about 153,102 (279)

BCL-XL regulates the timing of mitotic apoptosis independently of BCL2 and MCL1 compensation

Cell Death and Disease
Mitotic catastrophe induced by prolonged mitotic arrest is a major anticancer strategy. Although antiapoptotic BCL2-like proteins, including BCL-XL, are known to regulate apoptosis during mitotic arrest, adaptive changes in their expression can ...
Chun Yin Yu, Tsz Kwan Yeung, Wai Kuen Fu, Randy Y. C. Poon   +3 more
doaj   +1 more source

Relevance of Bcl-x expression in different types of endometrial tissues

Journal of Experimental & Clinical Cancer Research, 2010
Objectives To explore the roles of Bcl-xl and Bcl-xs in the development and progression of endometrial carcinoma, and to analyze the correlation between Bcl-xl and Bcl-xs.
Li Yanxia, Zhao Yanhui, Ma Xiaoxin, Lu Hongwei, He Yuanqi   +4 more
doaj   +1 more source

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA‐34a–BDNF–SIX3 signaling axis

Animal Models and Experimental Medicine, EarlyView.
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao, Chunlan Zou, Junxian Li, Yang Yang, Yuanyuan Han, Tingyu Ke   +5 more
wiley   +1 more source

BCL-xL is correlated with disease severity in neonatal infants with early sepsis

BMC Pediatrics, 2021
Background Sepsis is the most common cause of morbidity and mortality in neonatal infants. It is essential to find an accurate and sensitive biomarker to confirm and treat neonatal sepsis in order to decrease the rate of mortality.
Wu Wenshen, Peng Qi, Huang Tianli, Liao Jinfeng, Li Ning   +4 more
doaj   +1 more source

Modulation of bcl-xL in tumor cells regulates angiogenesis through CXCL8 expression

, 2007
In this paper, we investigated whether bcl-xL can be involved in the modulation of the angiogenic phenotype of human tumor cells. Using the ADF human glioblastoma and the M14 melanoma lines, and their derivative bcl-xL-overexpressing clones, we showed ...
Zangemeister-Wittke, Uwe, Trisciuoglio, Daniela, Giorgini, Simona, Gabellini, Chiara, Desideri, Marianna, Colarossi, Cristina, Castellini, Laura, Del Bufalo, Donatella, Zupi, Gabriella   +8 more
core   +1 more source

Regulation of apoptosis by an intrinsically disordered region of Bcl-xL [PDF]

Nature Chemical Biology, 2018
Intrinsically disordered regions (IDRs) of proteins often regulate function upon post-translational modification (PTM) through interactions with folded domains. An IDR linking two α-helices (α1-α2) of the antiapoptotic protein Bcl-xL experiences several PTMs that reduce antiapoptotic activity.
Ariele Viacava Follis, Fabien Llambi, Halime Kalkavan, Yong Yao, Aaron H. Phillips, Cheon-Gil Park, Francesca M. Marassi, Douglas R. Green, Richard W. Kriwacki   +8 more
openaire   +2 more sources

Reduction of Ribonucleotide Reductase Subunit RRM2 Potentially Impairs Gut Function of Woody Breast Broilers

Animal Research and One Health, EarlyView.
Woody breast compromises meat quality leading to reduced consumer appeal. Although its causes are unclear, improvements observed with certain dietary supplements suggest that gut health may influence woody breast development. Ribonucleotide reductase subunit RRM2 is vital for mitochondrial function and gastrointestinal integrity, and alteration in its ...
Majid Shakeri, Elizabeth Ziabtchenko, Janghan Choi, Caitlin E. Harris, Richard J. Buhr, Trevor R. Mitchell, Byungwhi Kong, Hong Zhuang, Brian Bowker   +8 more
wiley   +1 more source

Bcl-xL promotes metastasis independent of its anti-apoptotic activity

Nature Communications, 2016
Bcl-xL is an anti-apoptotic protein that has also been implicated in metastasis. In this study, the authors show that nuclear Bcl-xL promotes metastasis by regulating TGFβ signaling, which is independent of the anti-apoptotic activity of Bcl-xL.
Soyoung Choi, Zhengming Chen, Laura H. Tang, Yuanzhang Fang, Sandra J. Shin, Nicole C. Panarelli, Yao-Tseng Chen, Yi Li, Xuejun Jiang, Yi-Chieh Nancy Du   +9 more
doaj   +1 more source

Quantification of the Activities of BCL-2 and BCL-XL [PDF]

, 2003
Apoptosis is the process by which organisms eliminate excess, damaged or hazardous cells in a controlled manner. This process is controlled by the Bcl-2 family of proteins.
Fiebig, Aline
core  

Ultrasmall Fe‐curcumin immunomodulators reinvigorate CAR‐T cells to potentiate solid tumor immunotherapy by mitigating cell exhaustion and senescence

BMEMat, EarlyView.
This work discovered a novel research that ultrasmall Fe‐curcumin immunomodulators could reinvigorate CAR‐T cells to potentiate solid tumor immunotherapy by mitigating cell exhaustion and senescence. Abstract CAR‐T cell immunotherapy has achieved exciting success in hematologic malignancies, but the therapeutic efficacy is relatively limited in solid ...
Jiazhi Duan, Yuchan Xue, Miao Zhang, Zihao Zhang, Shiyu Peng, Minghao Sui, Han Ding, Yingying Nie, Yuemin Feng, Le Wang, Tianru Zhang, Mingchuan Yu, He Xia, Hong Liu, Qiang Zhu, Songbo Zhao   +15 more
wiley   +1 more source