Results 111 to 120 of about 153,102 (279)

The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition

BMC Cancer, 2012
Background It has been shown in many solid tumors that the overexpression of the pro-survival Bcl-2 family members Bcl-xL and Mcl-1 confers resistance to a variety of chemotherapeutic agents.
Peddaboina Chander, Jupiter Daniel, Fletcher Steven, Yap Jeremy L, Rai Arun, Tobin Richard P, Jiang Weihua, Rascoe Philip, Rogers M Karen, Smythe W, Cao Xiaobo   +10 more
doaj   +1 more source

Multidisciplinary Strategies for Targeting Tumor Dormancy in Breast Cancer Therapeutics: Hallmarks, Mechanism, and Approaches

iMetaMed, EarlyView.
Clinical phases and classification of breast tumor dormancy. Tumor dormancy is described as the period after treatment until residual tumor cells become detectable as relapsing disease in clinic. During the period of clinical tumor dormancy, tumor mass dormancy and cellular dormancy may coexist.
Shu Chen, Hui Chen, Vijaya Raghavan, Jing Huang, Jin Wang   +4 more
wiley   +1 more source

Bcl‐xL interrupts oxidative activation of neutral sphingomyelinase

FEBS Letters, 2002
Recent studies demonstrate a role for intracellular oxidation in the regulation of neutral sphingomyelinase (N‐SMase). Glutathione (GSH) has been shown to regulate N‐SMase in vitro and in cells. However, it has not been established whether the effects of GSH in cells are due to direct action on N‐SMase.
Okamoto, Yasuo, Obeid, Lina M, Hannun, Yusuf A   +2 more
openaire   +2 more sources

Extracellular Vesicle‐Mediated Communication Between Anterior Cruciate Ligament and Bone Marrow Cells Modulates Hamstring Tenocyte Behavior and Apoptosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Following anterior cruciate ligament (ACL) reconstruction, enhancing hamstring tenocyte activity and minimizing apoptosis are critical for preventing graft failure and promoting ligamentization. This study investigated the therapeutic potential of extracellular vesicles (EVs) derived from a coculture of ACL remnant cells and bone marrow ...
Hon‐Lok Lo, Shih‐Hao Huang, Ting‐Hsuan Dai, Shun‐Cheng Wu, Cheng‐Jung Ho, Cheng‐Chang Lu   +5 more
wiley   +1 more source

Bcl-xL regulates radiation-induced ferroptosis through chaperone-mediated autophagy of GPX4 in tumor cells

Radiation Medicine and Protection
Objective: To investigate the role and the molecular mechanisms of apoptotic signaling in ferroptosis to regulate tumor radiosensitivity. Methods: Reactive oxygen species (ROS) and lipid peroxide levels were detected in Mouse embryonic fibroblasts(MEFs ...
Jing Han, Ruru Wang, Bin Chen, Feng Xu, Liangchen Wei, An Xu, Lijun Wu, Guoping Zhao   +7 more
doaj   +1 more source

Autophagy Plays a Suppressive Role in Bladder Tumor Formation in an Orthotopic Mouse Model and Bladder Cancer Patient Specimens

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Autophagy plays either a suppressing or promoting role during tumor development. Clarifying the role of autophagy in bladder tumorigenesis both in vitro and in vivo is crucial for developing novel therapeutic strategies through manipulating autophagy activity.
Wan‐Ting Kuo, Chin‐Chen Pan, Yi‐Wen Liu, Nan‐Haw Chow, Hong‐Lin Cheng, Shan‐Ying Wu, Sheng‐Hui Lan, Chih‐Peng Chang, Hsiao‐Sheng Liu   +8 more
wiley   +1 more source

Small molecule-based drug design of anticancer agents that target protein kinase B/ AKT, Bcl-xL and DNA methyltransferases for the treatment of prostate cancer

, 2016
Prostate cancer is the most common form of cancer in men and the second leading cause of cancer-related deaths in the United States. So far, several mechanisms have been identified by which androgen-independent prostate cancer can develop, including ...
Shaw, Yeng-Jeng
core  

Amyloid Fibrils Formed by the Programmed Cell Death Regulator Bcl-xL.: Amyloid Fibrils from Bcl-xL

, 2011
International audienceThe accumulation of amyloid fibers due to protein misfolding is associated with numerous human diseases. For example, the formation of amyloid deposits in neurodegenerative pathologies is correlated with abnormal apoptosis.
Charlotte Vendrely, Clément E. Blanchet, Vincent Forge, Karst, Johanna C, Christine Almunia, Salin, Bénédicte, Gonneaud, Alexis, Catty, Patrice, Pichard, Sylvain, Hussy, Nicolas, Almunia, Christine, Sylvain Pichard, Daniel Gillet, Nicolas Hussy, Gillet, Daniel, Bénédicte Salin, Marquette, C.,, Blanchet, Clément,, Christel Marquette, Vitrac, Heidi, Blanchet, Clément, E., Heidi Vitrac, Forge, Vincent, Vendrely, Charlotte, Chenal, Alexandre, Marquette, C., M., Alexandre Chenal, Garcia, Elisabeth, Johanna C. Karst, Alexis Gonneaud, Patrice Catty, Elisabeth Garcia   +31 more
core   +1 more source

BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival [PDF]

, 2019
Malignant melanoma is one of the most difficult cancers to treat due to its resistance to chemotherapy. Despite recent successes with BRAF inhibitors and immune checkpoint inhibitors, many patients do not respond or become resistant to these drugs. Hence,
Herold, MJ, Gunasingh, Gency, Haass, Nikolas K., Mariadason, JM, Rohrbeck, Leona, Haass, NK, Celeste Ramnac (20505554), Zhu, H, Segal, D, Leona Rohrbeck (20505557), Harris, TJ, Evangelista, M, Strasser, A, Cebon, Jonathan, Dobrovic, Alexander, Mariadason, John M., John Mariadason (9487703), Fairlie, W. Douglas, Fairlie, WD, Zhu, Haoran, Jonathan Cebon (9483446), Herold, Marco J., Marco Herold (14857531), Segal, David, Gency Gunasingh (7138448), Tran, S, Evangelista, Marco, Thomas John (436356), John, T, Behren, A, Cebon, J, Alexander Dobrovic (9477641), Tiffany J Harris (10099990), Strasser, Andreas, Surein Arulananda (9474620), John, Thomas, Ramnac, C, Sharon Tran (9488795), Rohrbeck, L, Andreas Strasser (81188), Harris, Tiffany J., Lee, Erinna F., Walter Fairlie (9481229), Gunasingh, G, Lee, EF, Hobbs, Chloe, Haoran Zhu (7011287), Hobbs, C, Ramnac, Celeste, Andreas Behren (9477650), Dobrovic, A, Tran, Sharon, Marco Evangelista (1534441), Behren, Andreas, Arulananda, S, David Segal (4637467), Nikolas K Haass (20251986), Chloe Hobbs (18154813), Arulananda, Surein, Erinna Lee (9484976)   +59 more
core   +1 more source

Histiocytosis development and clinical variation through the lens of genomics

The Journal of Pathology, EarlyView.
Abstract Histiocytic neoplasms are rare haematologic diseases characterised by clonal expansions of cells with a monocyte, macrophage or dendritic cell phenotype. Their clinical manifestations are diverse, ranging from indolent lesions to aggressive systemic disease.
Paul G Kemps, Astrid GS van Halteren, Tom van Wezel, Pancras CW Hogendoorn   +3 more
wiley   +1 more source