Results 141 to 150 of about 153,102 (279)

OX40/OX40L modulation: A target for regulating T cells in cutaneous inflammatory disorders

Journal of the European Academy of Dermatology and Venereology, EarlyView.
OX40 and OX40L are a co‐stimulatory immune checkpoint pair. Modulation of this pair impacts multiple immune phenotypes and is an attractive target for immunotherapy in dermatological disorders. Trials are underway with the majority in atopic dermatitis and currently in phase 3 trials.
Aditya K. Gupta, Julia Steriopoulos, Vasiliki Economopoulos, Paradi Mirmirani, Vincent Piguet   +4 more
wiley   +1 more source

Structure-Based Design of Potent Bcl-2/Bcl-xL Inhibitors with Strong in Vivo Antitumor Activity

, 2016
Bcl-2 and Bcl-xL are key apoptosis regulators and attractive cancer therapeutic targets. We have designed and optimized a class of small-molecule inhibitors of Bcl-2 and Bcl-xL containing a 4,5-diphenyl-1H-pyrrole-3-carboxylic acid core structure.
Jeanne A. Stuckey (632892), Donna McEachern (573068), Haibin Zhou (573069), Longchuan Bai (387425), Liu Liu (512237), Shaomeng Wang (88290), Jennifer L. Meagher (1669465), Xin Cong (410807), Jianfang Chen (469733), Angelo Aguilar (573070), Chao-Yie Yang (695092)   +10 more
core   +1 more source

Prognostic Value of Bcl‐xL in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta‐Analysis

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background Head and neck squamous cell carcinoma is a heterogeneous disease with poor survival outcomes. Bcl‐xL regulates tumor cell survival and apoptosis and has been associated with metastasis and poor prognosis, although its overall role remains undeciphered.
L. Leinonen, R. Tiikkaja, M. Juola, P. Åström, T. Salo, K. Juurikka, K. Korelin   +6 more
wiley   +1 more source

Co-delivery of Aurora-A inhibitor XY-4 and Bcl-xl siRNA enhances antitumor efficacy for melanoma therapy

, 2018
Xingmei Duan,1,2,* Minjie Mu,3,* Junfeng Yan,1 Lan Bai,1 Lei Zhong,1 Yuxuan Zhu,1 Haixia Pan,1 Mei Zhang,3 Jianyou Shi1,3 1Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Provincial People`s Hospital ...
Pan H, Mu M, Yan J, Zhu Y, Bai L, Zhang M, Shi J, Duan X, Zhong L   +8 more
core  

Prolonged exposure to artificial light and carcinogenesis: A systematic review of oncostatic mechanisms associated with melatonin pathways

Photochemistry and Photobiology, EarlyView.
Exposure to artificial light at night (ALAN), particularly at blue wavelengths, disrupts circadian rhythms by suppressing melatonin, thereby increasing cancer susceptibility. This systematic review consolidates evidence linking prolonged ALAN exposure to an elevated risk of breast and prostate tumors.
Gabriel Barboza, Jêmina Oliveira, Antônio Ferreira, Renan Lopes, Marli Cupertino   +4 more
wiley   +1 more source

Effect of Bcl-xL and Bcl-xL phosphorylation mutant expression on cell population doubling of BJ cells.

, 2016
(A) Population doubling kinetics of control BJ cells and BJ cells expressing empty lentivirus vector or lentivirus vectors encoding HA-Bcl-xL(wt), (S49A), (S49D), (S62A), (S62D) or dual (S49/62A) and (S49/62D) phosphorylation mutants.
Myriam Beauchemin (3155202), Prasamit Saurav Baruah (3155196), Josée Hébert (235617), Richard Bertrand (3155199)   +3 more
core   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

301. Down-Regulation of bcl-xl Gene Expression with bcl-xl siRNA Vectors In Vitro and In Vivo

Molecular Therapy, 2005
Introduction: BCL-XL, an anti-apoptotic member of the bcl-2 gene family, is highly expressed in human lung cancer. Over-expression of BCL-XL has been correlated with conventional clinical treatment resistance. We previously demonstrated that down-regulation of BCL-XL expression by antisense will induce apoptosis and sensitize lung cancer cells to ...
openaire   +1 more source

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Bcl-2 and bcl-xL Antisense Oligonucleotides Induce Apoptosis in Melanoma Cells of Different Clinical Stages

, 2002
Recent clinical studies have shown the promise of bcl-2 antisense therapy in patients with melanoma. To further demonstrate the importance of bcl-2 and validate the related antiapoptotic protein bcl-xL as targets for antisense therapy in melanoma, their ...
Zangemeister-Wittke, Uwe, Robert A. Olie, Reinhard Dummer, Willers, Jörg, Olie, Robert A., Christoph Hafner, Hall, Jonathan, Küttel, Renzo, Sigrist, Brigitte, Dummer, Reinhard, Brigitte Sigrist, Stahel, Rolf A., Renzo Küttel, Rolf A. Stahel, Uwe Zangemeister-Wittke, Jonathan Hall, Hafner, Christoph, Jörg Willers   +17 more
core   +1 more source