Results 161 to 170 of about 153,102 (279)

Bcl-2/Bcl-xL Regulates Cell Cycle Through a Novel Mechanism in Addition to Cell Survival

, 2005
CANCER BIOLOGY BCL-2/BCL-XL REGULATES CELL CYCLE THROUGH A NOVEL MECHANISM IN ADDITION TO CELL SURVIVAL YELENA MELKUM JANUMYAN Dissertation under the direction of Professor Elizabeth Yang Bcl-2 and Bcl-xL are anti-apoptotic and inhibit ...
Janumyan, Yelena Melkum
core  

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Polymer Matrix‐Based 3D Culture Significantly Enhances the Differentiation and Immunomodulatory Functions of Human Adipose‐Derived Stem Cells

Advanced Science, Volume 13, Issue 34, 19 June 2026.
The 3D culture of human adipose‐derived stem cells (hADSCs) on a crosslinked cyclosiloxane‐based poly‐Z matrix platform enables the formation of spheroid structures enriched with extracellular matrix (ECM). These ECM‐enriched hADSC spheroids cultured on poly‐Z exhibit enhanced differentiation potential, immunomodulatory capacity, and in vivo ...
Changjin Seo, Dohyeon Kim, Junhyuk Song, Sun‐Young Kim, Youngju Son, Afia Tasnim Rahman, Sangyong Jon   +6 more
wiley   +1 more source

Synergistic Antitumor Activity of HAT Inhibitor A485 and XPO1 Inhibitor KPT8602 in Multiple Myeloma

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Multiple myeloma (MM) remains the second most common hematologic malignancy, necessitating the identification of novel therapeutic targets. MM is characterized by a distinct epigenetic landscape driven by aberrant chromatin activation and super‐enhancer addiction.
Hong Xu, Wenqi Wu, Yanan Jiang, Jinhuan Wang, Yixin Zhai, Zhigang Zhao   +5 more
wiley   +1 more source

C1orf226 Promotes Glioma Stemness and Oncogenesis in Glioma via PLK1‐Mediated Wnt/β‐Catenin Signaling

Cancer Medicine, Volume 15, Issue 6, June 2026.
High C1orf226 expression correlates with glioma aggressiveness and worse prognosis. C1orf226 promotes malignant phenotypes and stemness in glioma cells. C1orf226 interacts with PLK1 to stabilize β‐catenin and activate the Wnt/β‐catenin pathway. ABSTRACT Introduction Glioma stem cells (GSCs) are pivotal drivers of tumor progression and therapeutic ...
Yanbing Lu, Chao Jiang, Hongfei Wu, Junkui Shang, Bin Wang, Shundong Cang, Jiewen Zhang   +6 more
wiley   +1 more source

SIRT1: Protean roles at the nexus of health, disease, and therapeutics

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
SIRT1 serves as a central regulator linking metabolism, stress responses, and disease. It influences diverse processes, including transcriptional and posttranscriptional gene expression and protein activity, inflammation, mitochondrial function, and cell survival, through the deacetylation of multiple protein targets. While SIRT1 often plays protective
Brahim Chaqour
wiley   +1 more source

Bcl-xL and bcl-2 proteins in melanoma progression and UVB-induced apoptosis

, 2006
Whether bcl-xL and bcl-2 play an essential role in melanoma progression and UVB-induced apoptosis is not completely understood. We investigated the expression of bcl-xL and bcl-2 in matched primary and metastatic melanoma tumors and melanoma cell lines ...
Rosdahl, Inger,, Zhang, Hong,
core  

Programmed Cell Death in Chronic Rhinosinusitis

Clinical and Translational Allergy, Volume 16, Issue 6, June 2026.
ABSTRACT Chronic rhinosinusitis (CRS) is a prevalent upper respiratory condition characterized by a multifaceted etiology involving various cellular and molecular processes. In recent years, researchers have increasingly recognized the significance of different forms of programmed cell death (PCD), such as apoptosis and pyroptosis, in the pathological ...
Xingchen Liu, Junying Hu, Weigang Gan, Qi Wu, Bing Zhong, Feng Liu   +5 more
wiley   +1 more source

Phosphodiesterase 3A modulators sensitize tumor cells to Bcl-xL and Bcl-2/Bcl-xL inhibitors

Abstract Phosphodiesterase 3A (PDE3A) modulators are emerging anticancer agents for tumors that co-express PDE3A and Schlafen 12 (SLFN12), promoting the formation of a cytotoxic PDE3A-SLFN12 complex. The effect correlates with PDE3A and SLFN12 expression levels.
Kirsi Toivanen, Astrid Murumägi, Agnieszka Wozniak, Karo Wyns, Chao-Chi Wang, Luna De Sutter, Mariliina Arjama, Nanna Merikoski, Sami Salmikangas, Omar Youssef, Jorma Isola, Olli Kallioniemi, Patrick Schöffski, Tom Böhling, Harri Sihto   +14 more
openaire   +1 more source

Mevalonate pathway activation in Ewing sarcoma reveals a 3D-specific synergy between statins and BCL-xL inhibition. [PDF]

Mol Ther Oncol
Radic-Sarikas B, Markovic M, Zylka MM, Sturtzel C, Ilg M, Surdez D, Metzelder M, Distel M, Ovsianikov A, Halbritter F, Kovar H.   +10 more
europepmc   +2 more sources