Results 181 to 190 of about 153,102 (279)

Bcl-xL blockade targets neutrophils and synergizes with chemotherapy in lung squamous cell carcinoma. [PDF]

EMBO Mol Med
Mayet A, Parma B, Lécuyer D, Defruit A, Rana S, Bodac A, Demetter P, Denanglaire S, Ireland AS, Brandão M, Berghmans T, Andris F, Goriely S, Perentes JY, Oliver TG, Meylan E.   +15 more
europepmc   +1 more source

Distinct stem cell identities converge into shared erythroid stress in ERCC6L2 disease and Shwachman–Diamond syndrome

HemaSphere, Volume 10, Issue 6, June 2026.
Abstract ERCC6L2 disease (ED) is a rare bone marrow failure syndrome caused by biallelic germline mutations in ERCC6L2. ED leads to the accumulation of somatic TP53 mutations, myelodysplastic syndrome, and acute myeloid leukemia (AML) with erythroid predominance and poor prognosis.
Laura Langohr, Ilse Kaaja, Suvi P. M. Douglas, Hanna Nebelung, Jessica Koski, Ina Ikonen, Lotta Katainen, Katri Maljanen, Marja Hakkarainen, Tuulia Räisänen, Riitta Niinimäki, Sakari Kakko, Timo Siitonen, Sadiksha Adhikari, Markus Vähä‐Koskela, Caroline A. Heckman, Jenni Lahtela, Ulla Wartiovaara‐Kautto, Esa Pitkänen, Outi Kilpivaara   +19 more
wiley   +1 more source

BCL-2 and BCL-xL in Cancer: Regulation, Function, and Therapeutic Targeting. [PDF]

Int J Mol Sci
Silva JPN, Pinto B, Silva PMA, Bousbaa H.   +3 more
europepmc   +1 more source

SETD2 Deficiency Drives Mitochondrial DNA Leakage and Creates a Druggable Dependency on BCL-XL in Clear Cell Renal Cell Carcinoma. [PDF]

Cancer Res
Uprety A, Judd C, Villella ED, Keller R, Wagner R, Robertson KD, Rodriguez-Blanco J, Barnoud T, Mason FM, Ho TH, de Cubas AA.   +10 more
europepmc   +1 more source

Characterization of the Direct and Indirect Inhibition of Apoptosis by Full-Length Recombinant Bcl-xL Monomers. [PDF]

Chembiochem
Elsner C, Epasto LM, Cieren A, Gendreizig D, Kucher S, Roderer D, Bordignon E.   +6 more
europepmc   +1 more source

Crystal Structure of Rat Bcl-xL [PDF]

Journal of Biological Chemistry, 1997
Masaharu Aritomi, Naoki Kunishima, Naohiro Inohara, Yoshitomo Ishibashi, Shigeo Ohta, Kosuke Morikawa   +5 more
openaire   +1 more source

SMARCA4/2 loss reduces BCL-xL expression and confers a druggable MCL1 dependency in cancer. [PDF]

NPJ Precis Oncol
Jiang J, Zhu X, Fu Z, Liao M, Arabzadeh A, Robert F, Monast A, Pilon V, Pavlakis K, Park M, Foulkes WD, Huang S.   +11 more
europepmc   +1 more source

Role of Bcl-2 and Bcl-xL in angiogenesis.

, 2006
Tumor progression is dependent on angiogenesis, the process of the new vessel formation from pre-existing capillaries. Vascular endothelial growth factor (VEGF), a key regulator of tumor angiogenesis, enhances endothelial cell survival via upregulation ...
Karl, Elisabeta
core  

A Theoretical Model for the Treatment of Androgenetic Alopecia Using the STEAP3 Protein, and the Genetic Challenges of Treating AGA

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Androgenetic alopecia (AGA) is a prevalent condition. The treatment methods currently available for this condition have limited potential (minoxidil) and side effects with long‐term therapy that affect the physiology of the male population (5α‐reductase inhibitors).
Ignacy Klemens Młodzianowski, Małgorzata Grochocka, Tadeusz Tadrowski, Marta Hałas‐Wiśniewska, Magdalena Izdebska   +4 more
wiley   +1 more source

Vacuolization as a Novel Approach to Cancer Therapy

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak, Noor Hussein, Veronica Piedra, Saloni Malla, Chandrabose Karthikeyan, Haneen Amawi, Harish Rajak, Charles R. Ashby Jr., R. Jayachandra Babu, Amit K. Tiwari   +9 more
wiley   +1 more source