Results 241 to 250 of about 153,102 (279)

A novel regimen for pancreatic ductal adenocarcinoma targeting MEK, BCL-xL, and EGFR. [PDF]

Neoplasia
Han S, Tushoski-Alemán GW, Zhang P, Zheng G, Zhou D, Huo Z, Licht J, George TJ, Allegra C, Trevino JG, Hughes SJ.   +10 more
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Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis. [PDF]

Cancer Lett
Zhang T, Li S, Tan YA, Chen X, Zhang C, Chen Z, Mishra B, Na JH, Choi S, Shin SJ, Damle P, Chougoni KK, Grossman SR, Wang D, Jiang X, Li Y, Hissong E, Chen YT, Xiang JZ, Du YN.   +19 more
europepmc   +1 more source

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Bcl-xL as an antiapoptotic molecule for cardiomyocytes

Drug News & Perspectives, 2003
It is now widely accepted that two forms of cell death, apoptosis and necrosis, occur in cardiomyocytes, and increasing evidence indicates that apoptosis plays an important role in the pathophysiology of cardiovascular diseases. Currently, two major pathways in the induction of apoptosis are known to occur in cardiomyocytes, the mitochondrial pathway ...
Yukiyo, Ogata, Masafumi, Takahashi
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BCL-xL MD and PSN

2021
Collection of simulations and free energy calculations used in the publication Bcl-xL dynamics under the lens of protein structure networks. Valentina Sora, Dionisio Sanchez, Elena Papaleo*,J Phys Chem B, 2021, 125(17):4308-4320. doi: 10.1021/acs.jpcb.0c11562.
Tiberti, Matteo, Sora, Valentina, Papaleo, Elena, Cabrera, Dionisio Sánchez   +3 more
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Role of BCL-XL in Photoreceptor Survival

2008
Photoreceptors are post-mitotic neurons and understanding their survival mechanisms holds a key to the treatment of retinal degeneration. Many studies have demonstrated that phosphoinositide 3-kinase (PI3K) and its product phosphatidylinositol-3,4,5-trisphosphate (PIP3) are involved in the survival of neurons through growth factor receptor-mediated ...
Yun-Zheng, Le, Lixin, Zheng, Yuwei, Le, Edmund B, Rucker, Robert E, Anderson   +4 more
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Sequence of Bcl-XL Antisense Oligonucleotides

Blood, 1999
To the Editor: In their report, Dibbert et al[1][1] had described that spontaneous eosinophil apoptosis was associated with a decrease in the levels of the antiapoptotic Bcl-XL protein. Because they also observed that granulocyte-macrophage colony-stimulating factor or interleukin-5 could ...
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BCL-XL directly retrotranslocates the monomeric BAK

Cellular Signalling, 2019
BCL-XL, an anti-apoptotic BCL-2 family protein, potently inhibits BAK oligomerization and the formation of toxic mitochondrial pores in response to cellular stress. This report aims to explore which form of mitochondrial monomeric and oligomerized BAK can be retrotranslocated by BCL-XL.
Bin Wang, Zihao Mai, Mengyan Du, Lu Wang, Fangfang Yang, Yunyun Ma, Xiaoping Wang, Tongsheng Chen   +7 more
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BCL-xL Regulates Synaptic Plasticity

Molecular Interventions, 2006
Mitochondria are the predominant organelle within many presynaptic terminals. During times of high synaptic activity, they affect intracellular calcium homeostasis and provide the energy needed for synaptic vesicle recycling and for the continued operation of membrane ion pumps.
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Bcl-xL overexpression in human hepatocellular carcinoma

International Journal of Oncology, 2002
It is known that proliferation and apoptosis are closely related phenomena in liver cancer cells. In this study, using surgical specimens from 42 patients with hepatocellular carcinoma (HCC), we investigated the expression and localization of Bcl-xL, an antiapoptosis-related protein of the Bcl-2 family.
Jota, Watanabe, Fumiki, Kushihata, Kazuo, Honda, Katsumi, Mominoki, Seiji, Matsuda, Nobuaki, Kobayashi   +5 more
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Discovery and optimization of covalent Bcl-xL antagonists

Bioorganic & Medicinal Chemistry Letters, 2019
Over the last ten years, targeted covalent inhibition has become a key discipline within medicinal chemistry research, most notably in the development of oncology therapeutics. One area where this approach is underrepresented, however, is in targeting protein-protein interactions.
Herschel, Mukherjee, Nancy, Su, Matthew A, Belmonte, David, Hargreaves, Joe, Patel, Sharon, Tentarelli, Brian, Aquila, Neil P, Grimster   +7 more
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