Results 251 to 260 of about 153,102 (279)
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A new assay for the discovery of Bcl-XL inhibitors
Il Farmaco, 2005The Bcl-2 family of antiapoptotic proteins is commonly over expressed in many types of human cancer and remains one of the few validated targets. Antiapoptotic family proteins such as Bcl-2 and Bcl-XL function, at least in part, by binding proapoptotic members such as Bax and Bak and thereby prevent release of the apoptotic cascade of events. "BH3-only"
Cristina, Pisoni +6 more
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Bax-independent inhibition of apoptosis by Bcl-XL
Nature, 1996The Bcl-2-related protein, Bcl-XL, has been shown to block apoptosis induced by a variety of stimuli and to be a stronger protector against apoptosis than Bcl-2 under certain circumstances. Using site-specific mutagenesis, we show here that the amino-acid residues critical for protection of cells by Bcl-XL against Sindbis virus-induced apoptosis are ...
E H, Cheng +4 more
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Bcl-xL Deamidation a Trigger for Apoptosis
Science's STKE, 2007Using a transgenic mouse as a model for T cell lymphoma, Zhao et al . provide evidence that defective deamidation of Bcl-xL contributes to the apoptosis resistance and oncogenesis of thymocytes in these animals. These mice ( CD45 −/− lck F505
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From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors
Nature Reviews Drug Discovery, 2017Avi Ashkenazi +2 more
exaly
Regulation of Lymphocyte Survival by the BCL-2 Gene Family
Annual Review of Immunology, 1995Suzanne Cory
exaly