Results 121 to 130 of about 134,892 (289)
A mouse model of lung ischemia–reperfusion injury with reversible left hilar entrapment
Animal Models and Experimental Medicine, EarlyView.A Novel Reversible Left Hilar Entrapment Model for Mouse Lung Ischemia‐Reperfusion Injury with Visual Tracheal Intubation and Live Knot Technique. Abstract Lung ischemia–reperfusion injury (LIRI), an acute lung injury syndrome triggered by lung transplantation or distal organ ischemia, has long been a difficult and hot issue in clinical research.
GuangDong Weng +4 more
wiley +1 more source
Blood DDIT4 and TRIM13 Transcript Levels Mark the Early Stages of Machado–Joseph Disease
Annals of Neurology, EarlyView.Objective An abundance of select transcripts and proteins has been found to be dysregulated in blood samples of Machado–Joseph disease (MJD) carriers. Here, we aimed to: (1) identify blood transcriptional changes as potential biomarkers of MJD; (2) correlate levels of differentially expressed blood transcripts with MJD carriers features; and (3 ...
Ana F. Ferreira +10 more
wiley +1 more source
miR-424-5p regulates apoptosis and cell proliferation via targeting Bcl2 in nucleus pulposus cells
Animal Cells and Systems, 2020 Background miRNAs play an important role in the pathogenesis of intervertebral disc degeneration (IDD). The role and the underlying mechanism of miR-424-5p in human nucleus pulposus (NP) are still unknown.
Hua-tuo Lu +3 more
doaj +1 more source
Attenuation of hedgehog/GLI signaling by NT1721 extends survival in pancreatic cancer. [PDF]
, 2019 BackgroundPancreatic cancer is one of the most lethal malignancies due to frequent late diagnosis, aggressive tumor growth and metastasis formation.
Horne, David A +4 more
core +1 more source
Targeting BCL2-Proteins for the Treatment of Solid Tumours [PDF]
Advances in Medicine, 2014 Due to their central role in the regulation of apoptosis, the antiapoptotic BCL2-proteins are highly promising targets for the development of novel anticancer treatments. To this end, several strategies have been developed to inhibit BCL2,BCL-XL, BCL-w, and MCL1.
openaire +4 more sources
Advanced NanoBiomed Research, EarlyView.Chemically modified graphene oxide nanocarriers provide a targeted lung cancer gene therapy platform. In a 3D tumor microenvironment model, these nanocarriers deliver therapeutic genes, regulate immune markers, and induce apoptosis in cancer cells. Combined gene delivery enhances cancer cell elimination, demonstrating the potential of this approach for
Francesca Grilli +3 more
wiley +1 more source
Evaluating the effects of hypoxia and taper on expression of Pulmonary Bax and Bcl2 apoptotic proteins [PDF]
Journal of Advanced Biomedical Sciences, 2018 Background & Objective: Due to The limitation of research literature, related to the effect of exercise training with different intensity, Along with Hypoxia Stress on Pulmonary Apoptosis, The purpose of this study was to investigate the effects of ...
Mehdi Yadegari +5 more
doaj
Typhonium flagelliforme decreases protein expression in murine breast cancer
Universa Medicina, 2014 BACKGROUND Breast cancer treatment is still ineffective, having also various side effects. Breast cancer growth is affected by human epidermal growth factor receptor 2 (HER2/neu) and B cell lymphoma 2 (BCL2) expression.
Chodidjah Chodidjah +2 more
doaj +1 more source
De novo design of bioactive protein switches. [PDF]
, 2019 Allosteric regulation of protein function is widespread in biology, but is challenging for de novo protein design as it requires the explicit design of multiple states with comparable free energies. Here we explore the possibility of designing switchable
Baker, David +14 more
core
Tumor Biology, 2015 BCL2 (B-cell leukemia/lymphoma 2) gene functions as antiapoptotic regulatory element and known to be associated with tumorigenesis. The SNP-938 (C>A) (rs2279115), located in the inhibitory P2 promoter of the BCL2 gene, influences differential binding affinities of transcriptional factors thereby affecting BCL2 expression.
Sandhya Annamaneni +8 more
openaire +3 more sources