Results 101 to 110 of about 108,551 (297)

BAK1 (BCL2-antagonist/killer 1) [PDF]

, 2010
Review on BAK1 (BCL2-antagonist/killer 1), with data on DNA, on the protein encoded, and where the gene is ...
Dewson, G, R Kluck, Kluck, R, G Dewson
core   +1 more source

A C‐Nucleoside Analogue of Cordycepin With High Metabolic Stability and Potent Anti‐Psoriatic Activity via Microneedle Delivery

Advanced Science, EarlyView.
This work identified CPD3a as a potent, stable C‐nucleoside cordycepin derivative. When formulated into microneedle array for topical treatment, it ameliorated psoriasis by rebalancing immunity and enhancing antioxidant defenses. ABSTRACT Psoriasis is a chronic inflammatory disorder characterized by immune dysregulation and epidermal hyperplasia ...
Wenfang Pan, Xinyue Shao, Yuanchen Zhong, Xujie Sun, Lixuan Yin, Zongyan He, Tianqun Lang, Yuanchao Xie   +7 more
wiley   +1 more source

Post-transcriptional and post-translational regulation of Bcl2

, 2010
Bcl2 is an important pro-survival protein that has an essential function in normal immunity and whose constitutive expression leads to the development of lymphomas.
Shaun Willimott, Simon D. Wagner
core   +1 more source

Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy [PDF]

, 2015
SummaryThe BH4 domain of Bcl2 is required for its antiapoptotic function, thus constituting a promising anticancer target. We identified a small-molecule Bcl2-BH4 domain antagonist, BDA-366, that binds BH4 with high affinity and selectivity. BDA-366-Bcl2
Zhou, Jia, Xie, Maohua, Khuri, Fadlo R., Deng, Xingming, Chen, Zhuo G., Sica, Gabriel L., Ding, Chunyong, Curran, Walter J., Ramalingam, Suresh S., Shin, Dong M., Zhang, Guojing, Li, Rui, Park, Dongkyoo, Han, Bingshe, Magis, Andrew T., Owonikoko, Taofeek K.   +15 more
core   +1 more source

The CXCL5/CXCR2 Axis Attenuates Ferroptosis in Intrahepatic Cholangiocarcinoma Through the Positive Feedback Loop Between PTGS2 Transcriptional Activation and Neutrophil Recruitment

Advanced Science, EarlyView.
The CXCL5/CXCR2 axis directly inhibits ferroptosis in ICC cells by activating the NF‐κB/PTGS2 pathway. Meanwhile, the CXCL5/CXCR2 axis recruits N2 TANs, and the activated PTGS2 promotes the secretion of TNF‐α from the recruited N2 TANs via the CCL2/CCL7/CCR2 pathway, thereby activating the NF‐κB/PTGS2 axis and forming a positive feedback loop, which ...
Chanqi Ye, Kefeng Lin, Shuyao Yang, Yan Zhang, Wenli Gao, Jiaqi Chen, Ying Dong, Rui Bai, Yang Tian, Minghao Wang, Zhijun Yuan, Yuxiao Ma, Yuqin He, Ruyin Chen, Wenguang Fu, Qi Jiang, Qiong Li, Jian Ruan   +17 more
wiley   +1 more source

Role of c-MYC, BCL2, and BCL6 Expression in Pathogenesis of Diffuse Large B-Cell Lymphoma

Клиническая онкогематология, 2014
According to modern concepts based on results of examination of the gene expression profile, there are several subtypes of diffuse large B cell lymphoma (DLBCL): germinal center B cell-like (GCB) and activated B cell-like (ABC) lymphomas.
A. E. Misyurina, V. A. Misyurin, E. A. Baryakh, A. M. Kovrigina, S. K. Kravchenko   +4 more
doaj   +1 more source

Bcl2 activity in left ventricle.

, 2014
A, B, C, D, showing high cytoplasmic expression of bcl2 by cardiac myocytes (thick arrow), and endothelial cells (arrow head) at 30 minutes post MI in an area supplied by LAD in the left ventricle, streptavidin- biotin immunoperoxidase method.
Suhail Al-Salam (518026), Satwat Hashmi (518027)   +1 more
core   +1 more source

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu, Wanying Chen, Haijiang Qiu, Weihan Zheng, Ying Jiao, Jingheng Du, Zhudan Zhuang, Xing Hua, Jingyi Gu, Yuheng Liu, Zhaojin Li, Jingbin Xie, Hanxiao Sun, Huifei Lan, Xin Sun, Yunxia Xue, Ting Fu, Zhijie Li, Guobing Chen, Shiyu Li, Jun Liu   +20 more
wiley   +1 more source

Gossypol Suppresses Growth of Temozolomide-Resistant Glioblastoma Tumor Spheres

Biomolecules, 2019
Temozolomide is the current first-line treatment for glioblastoma patients but, because many patients are resistant to it, there is an urgent need to develop antitumor agents to treat temozolomide-resistant glioblastoma.
Hee Yeon Kim, Byung Il Lee, Ji Hoon Jeon, Dong Keon Kim, Seok-Gu Kang, Jin-Kyoung Shim, Soo Youl Kim, Sang Won Kang, Hyonchol Jang   +8 more
doaj   +1 more source

AUF1 binding to Bcl2 mRNA is reduced in the absence of the Bcl2 ARE-rich sequence.

, 2015
A, Analysis of AUF1 protein expression in splenic B cells from Bcl2-AREflox/flox x mb1wt (flox/flox) and Bcl2-AREflox/flox x mb1cre (∆/∆) mice. Two different amounts of total cell lysates (10 and 20 μg) were loaded in SDS-PAGE gels.
Manuel D. Díaz-Muñoz (697559), Martin Turner (391990), Sarah E. Bell (697560)   +2 more
core   +1 more source