Results 91 to 100 of about 108,551 (297)

Modeling a Data Mining Decision Tree and Propose a New Model for the Diagnosis of Skin Cancer by Immunohistochemical Staining Methods

مجله انفورماتیک سلامت و زیست پزشکی, 2014
Introduction: New diagnostic methods like immunohistochemistry staining in skin cancer can help the physicians to have more accurate diagnosis. The purpose of this study was to compare a method based on decision tree for differential diagnosis of two ...
Afshin Sarafi Nejad, Amirhossein Saeid, Isa Mohammed Rose, Alireza Rowhanimanesh   +3 more
doaj  

Targeting BCL2 for the Treatment of Lymphoid Malignancies

Seminars in Hematology, 2014
The failure of apoptosis (programmed cell death) underpins the development of many tumors and often renders them resistant to cytotoxic therapies. In hematologic malignancies, this impairment of apoptosis is often caused by overexpression of the pro-survival protein BCL2.
Anderson, Mary Ann, Huang, David, Roberts, Andrew   +2 more
openaire   +2 more sources

RBP2 directly targets the promoter of BCL2.

, 2016
(A) Predicted binding sites of RBP2 in the BCL2 promoter (-1078~-1620) were divided into regions a, b, and c. (B) ChIP assay for binding of RBP2 to BCL2 promoter regions a, b, and c.
Jihui Jia (439139), Xiaoming Wang (187053), Minran Zhou (2578516), Ting Sun (137181), Yuan Yu (241193), Xuemei Qin (620090), Chunyan Chen (95808), Yue Fu (64387), Jin Chen (130241)   +8 more
core   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

The predictive value of immunohistochemistry for MYC, BCL2, and BCL6 in fluorescence in situ hybridization in aggressive mature B-cell lymphomas and re-evaluation according to the 5th edition of the World Health Organization classification: A single-center 9-year experience

Indian Journal of Pathology and Microbiology
Background: Diffuse large B-cell lymphoma/High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 translocations (DLBCL/HGBL-MYC/BCL2) represent a distinct and rare diagnostic category in 5th Edition World Health Organization (WHO-HAEM5) classification.
Nuray Bassullu, Fatma Tokat, Irem Guvendir, Cansu Gokpinar, Tulay Tecimer   +4 more
doaj   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

miR-15 and miR-16 induce apoptosis by targeting BCL2

, 2005
Chronic lymphocytic leukemia (CLL) is the most common human leukemia and is characterized by predominantly nondividing malignant B cells overexpressing the antiapoptotic B cell lymphoma 2 (Bcl2) protein. miR-15a and miR-16-1 are deleted or down-regulated
Wojcik S. E., Rassenti L., Volinia S., Dono M., Iorio M. V., Shimizu M., Kipps T. J., NEGRINI, Massimo, Liu C. G., Fabbri M., FERRACIN, MANUELA, Aqeilan R. I., Zupo S., Alder H., Negrini M., Cimmino A., Calin G. A., VOLINIA, Stefano, Croce C. M., CROCE, Carlo Maria   +19 more
core   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Cloning of a mouse Bcl2-Nek9 chimeric cDNA.

, 2016
A: Using Bcl2-L1211 and Bcl2-R2i primers in PCR to amplify an RT product from Ela-mycPT1 cells resulted in not only the anticipated band of the Bcl2-β mRNA variant at the top but also a smaller band of about 500 bps (arrowhead).
D. Joshua Liao (140193), Bingkun Xie (817527), Yongchang Ouyang (2696659), Hesheng Jiang (43529), Wei Yang (109917), Lichan Chen (1540672), Yuying Liao (2696656)   +6 more
core   +1 more source

RGS16 Aggravates Hepatic Ischemia‐Reperfusion Injury via Hepatocyte‐Intrinsic Apoptosis/Inflammation & Neutrophil Recruitment/NETosis

Advanced Science, EarlyView.
RGS16 competitively interferes with the YTHDF3–PAN3 complex to prevent CXCL1 mRNA decay during hepatic ischemia‐reperfusion injury. Stabilized CXCL1 strengthens hepatocyte injury, neutrophil recruitment, and NET‐associated inflammation, uncovering how stress‐induced RGS16 converts post‐transcriptional regulation into immune‐mediated liver damage ...
Xinglong Li, Zhanzhi Meng, Hongjun Yu, Yongliang Hua, Zihao Li, Bing Yin, Baolin Qian, Zhongyu Li, Yongzhi Zhou, Zhigang Feng, Shounan Lu, Shanjia Ke, Miaoyu Bai, Yao Fu, Wei Tang, Natalia V. Belosludtseva, Yong Ma   +16 more
wiley   +1 more source