Results 11 to 20 of about 134,892 (289)
Phosphorylation of Bcl2 and regulation of apoptosis [PDF]
Leukemia, 2001 Members of the Bcl2 family of proteins are important regulators of programmed cell death pathways with individual members that can suppress (eg Bcl2, Bcl-XL) or promote (eg Bax, Bad) apoptosis. While the mechanism(s) of Bcl2's anti-apoptotic function is not yet clear, introduction of Bcl2 into most eukaryotic cell types will protect the recipient cell ...
Peter P. Ruvolo +2 more
openaire +2 more sources
Lack of expression of TUBB3 characterizes both BCL2-positive and BCL2-negative follicular lymphoma [PDF]
Modern Pathology, 2014 Follicular lymphoma is characterized by aberrant BCL2 expression, a feature that is exploited for diagnostic purposes. However, a certain percentage of follicular lymphomas might be BCL2-negative by immunohistochemistry, increasing the difficulties in differentiating them from follicular hyperplasia.
ZAMO', Alberto +3 more
openaire +5 more sources
Venetoclax inhibits autophagy in chronic lymphocytic leukemia cells
Autophagy Reports, 2023 Venetoclax (VCX) is a BCL2 inhibitor approved for treating B cell-derived leukemia, including chronic lymphocytic leukemia (CLL). VCX’s role in apoptosis induction is well-defined, whereas its other mechanistic roles need to be clarified. Autophagy is an
Yongqiang Chen +6 more
doaj +1 more source
Inverting the BTK-BCL2 order [PDF]
Blood, 2020 In this issue of Blood, Lin et al report the first long-term follow-up data showing that Bruton tyrosine kinase inhibitors (BTKi's) are effective in chronic lymphocytic leukemia (CLL) after previous progression on venetoclax.
openaire +3 more sources
BCL2 Regulates Differentiation of Intestinal Fibroblasts [PDF]
Inflammatory Bowel Diseases, 2018 Fibrosis in patients with Crohn's disease (CD) results from an imbalance toward excessive fibrous tissue formation driven by fibroblasts. Activation of fibroblasts is linked to the B-cell lymphoma 2 (BCL2) family, which is involved in the induction of apoptosis.
Weder, Bruce +6 more
openaire +4 more sources
BCL2 regulates neural differentiation. [PDF]
Proceedings of the National Academy of Sciences, 1996 A main function attributed to the BCL2 protein is its ability to confer resistance against apoptosis. In addition to the constitutively high expression of BCL2, caused by gene rearrangement in follicular lymphomas, elevated expression of the BCL2 gene has been found in differentiating hematopoietic, neural, and epithelial tissues.
Leif C. Andersson +3 more
openaire +3 more sources
Bcl2 negatively regulates Protective Immune Responses During Mycobacterial Infection
Biomolecular Concepts, 2021 We previously reported that M. tb on its own as well as together with HIV inhibits macrophage apoptosis by upregulating the expression of Bcl2 and Inhibitor of Apoptosis (IAP).
Singh Aayushi +7 more
doaj +1 more source
BCL2 genotypes and prostate cancer survival [PDF]
Strahlentherapie und Onkologie, 2017 The antiapoptotic B‑cell lymphoma 2 (BCL2) gene is a key player in cancer development and progression. A functional single-nucleotide polymorphism (c.-938C>A, rs2279115) in the inhibitory P2 BCL2 gene promoter has been associated with clinical outcomes in various types of cancer. Aim of the present study was to analyze the role of BCL2-938C>A genotypes
Wilfried Renner +4 more
openaire +3 more sources
Scutellarein apoptosis mediated by mitochondria in oral squamous cell carcinomas
Biomedical and Biotechnology Research Journal, 2022 Background: The growth of several cancers can be inhibited by naturally occurring medicinal plants. A flavone called Scutellarein found in the perennial herb Scutellaria lateriflora does have a wide range of biological functions. Scutellarein was studied
Markandan Birundadevi +2 more
doaj +1 more source
Bcl2 is an independent prognostic marker of triple negative breast cancer (TNBC) and predicts response to anthracycline combination (ATC) chemotherapy (CT) in adjuvant and neoadjuvant settings [PDF]
, 2013 Background: TNBC represents a heterogeneous subgroup of BC with poor prognosis and frequently resistant to CT. Material and methods: The relationship between Bcl2 immunohistochemical protein expression and clinicopathological outcomes was assessed in 736
Abdel-Fatah +15 more
core +1 more source