Results 41 to 50 of about 108,551 (297)

High Ki67 proliferation index but not cell-of-origin subtypes is associated with shorter overall survival in diffuse large B-cell lymphoma

Avicenna Journal of Medicine, 2020
Background: CD10, BCL6, and MUM1 are commonly used immunohistochemical stains for classifying diffuse large B-cell lymphoma (DLBCL), which is useful in predicting outcome.
Feras Zaiem, Rada Jerbi, Omar Albanyan, Jordyn Puccio, Zyad Kafri, Jay Yang, Ali M Gabali   +6 more
doaj   +1 more source

Reduced BCL2 and CCND1 mRNA expression in human cervical cancer HeLa cells treated with a combination of everolimus and paclitaxel [PDF]

, 2016
Aim of the study : Cervical cancer is the second most common malignancy in women worldwide. Everolimus displays direct effects on growth and proliferation of cancer cells via inhibition of mammalian target of rapamycin (mTOR) protein, which is known to ...
Menevse, Sevda, Onen, H Ilke, Menev e, Sevda, Onen, H.I., ÖNEN, HACER İLKE, Menevse, S., Alp, Ebru, Akin Yilmaz, Sevda Menevse, H. Ilke Onen, Y lmaz, Ak n, Ebru Alp, Önen, Hacer lke, Yilmaz, A., Alp, E., Yilmaz, Akin   +15 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Primary Cutaneous Follicle Center Lymphomas Expressing BCL2 Protein Frequently Harbor BCL2 Gene Break and May Present 1p36 Deletion

, 2016
International audienceThe classification of cutaneous follicular lymphoma (CFL) into primary cutaneous follicle center lymphoma (PCFCL) or secondary cutaneous follicular lymphoma (SCFL) is challenging.
Ortonne, Nicolas, Copie-Bergman, Christiane, Ingen-Housz-Oro, Saskia, Baia, Maryse, Szablewski, Vanessa, Delfau-Larue, Marie-Hélène   +5 more
core   +1 more source

BAG1 (BCL2-associated athanogene) [PDF]

, 2009
Review on BAG1 (BCL2-associated athanogene), with data on DNA, on the protein encoded, and where the gene is ...
Skeen, V, Southern, SL, Williams, AC
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Transcriptome analysis of ABCB1, ABCG2 and the BCL2/BAX ratio in refractory and relapsed canine lymphomas under treatment and rescue protocol

Acta Veterinaria, 2018
The main problems that cause unresponsiveness to an anti-neoplastic drug are the overexpression of drug resistant and anti-apoptotic proteins in tumor cells.
Sirivisoot Sirintra, Teewasutrakul Patharakrit, Rungsipipat Anudep, Tangkawattana Sirikachorn, Techangamsuwan Somporn   +4 more
doaj   +1 more source

Efficient Delivery of Therapeutic siRNA by Fe₃O₄ Magnetic Nanoparticles into Oral Cancer Cells

Pharmaceutics, 2019
The incidence of oral cancer is increasing due to smoking, drinking, and human papillomavirus (HPV) infection, while the current treatments are not satisfactory.
Lili Jin, Qiuyu Wang, Jiayu Chen, Zixiang Wang, Hongchuan Xin, Dianbao Zhang   +5 more
doaj   +1 more source

BAX/BCL2 ratio in chronic lymphocytic leukemia and its association with ZAP-70 expression and other clinicopathological parameters

Iraqi Journal of Hematology, 2020
BACKGROUND: Chronic lymphocytic leukemia (CLL) is a heterogeneous disease with a highly variable clinical course and outcome. Many clinical and biological characteristics have been used to classify patients with CLL into different subgroups of variable ...
Rihab Malik Rahid, Maysem Mouayad Alwash
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source