Results 41 to 50 of about 146,281 (306)

Bcl2 is an independent prognostic marker of triple negative breast cancer (TNBC) and predicts response to anthracycline combination (ATC) chemotherapy (CT) in adjuvant and neoadjuvant settings [PDF]

, 2013
Background: TNBC represents a heterogeneous subgroup of BC with poor prognosis and frequently resistant to CT. Material and methods: The relationship between Bcl2 immunohistochemical protein expression and clinicopathological outcomes was assessed in 736
Abdel-Fatah, Ali, Amos, Barrans, Brouckaert, Callagy, Dawson, Gasparini, O'Reilly, Ossovskaya, Paik, Perou, Reed, Sierra, van Slooten, von Minckwitz   +15 more
core   +1 more source

BCL2L1 (BCL2-like 1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on BCL2L1 (BCL2-like 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Varna, M, Ratajczak, P, Bertheau, P, Janin, A   +3 more
openaire   +2 more sources

Age related neoplasm in experimental animals [PDF]

Iraqi Journal of Veterinary Sciences
The albino rats are commonly recognized as tumor-resistant and appreciable research interest because of the scarcity of reports and article papers on neoplasm tumors.
Hadil B. Al-Sabaawy
doaj   +1 more source

Cell death and life in cancer: mathematical modeling of cell fate decisions

, 2011
Tumor development is characterized by a compromised balance between cell life and death decision mechanisms, which are tighly regulated in normal cells.
Barillot, Emmanuel, Calzone, Laurence, Fourquet, Simon, Tournier, Laurent, Zinovyev, Andrei   +4 more
core   +2 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

p53 and bcl2 expression in malignant and premalignant lesions of uterine cervix and their correlation with human papilloma virus 16 and 18

South Asian Journal of Cancer, 2014
Background and Objective: Persistent high risk human papilloma virus (HPV) infection is probably the best predictor of increased risk of cervical cancer, but expression of certain markers of cell proliferation and apoptosis have been studied. The present
Shailaja Shukla, Jasmita Dass, Mukta Pujani   +2 more
doaj   +1 more source

BAX/BCL2 ratio in chronic lymphocytic leukemia and its association with ZAP-70 expression and other clinicopathological parameters

Iraqi Journal of Hematology, 2020
BACKGROUND: Chronic lymphocytic leukemia (CLL) is a heterogeneous disease with a highly variable clinical course and outcome. Many clinical and biological characteristics have been used to classify patients with CLL into different subgroups of variable ...
Rihab Malik Rahid, Maysem Mouayad Alwash
doaj   +1 more source

Non-Hodgkin and Hodgkin Lymphomas Select for Overexpression of BCLW. [PDF]

, 2017
Purpose: B-cell lymphomas must acquire resistance to apoptosis during their development. We recently discovered BCLW, an antiapoptotic BCL2 family member thought only to contribute to spermatogenesis, was overexpressed in diffuse large B-cell lymphoma ...
Adams, Clare M., Eischen, Christine M., Gong, MD, Jerald Z., Mitra, Ramkrishna   +3 more
core   +1 more source

Biophysical and biochemical characterization of a liposarcoma-derived recombinant MnSOD protein acting as an anticancer agent [PDF]

, 2008
A recombinant MnSOD (rMnSOD) synthesized by specific cDNA clones derived from a liposarcoma cell line was shown to have the same sequence as the wild-type MnSOD expressed in the human myeloid leukaemia cell line U937, except for the presence of the ...
A. BORRELLI, A. MANCINI, A. SCHIATTARELLA, D. PAGNOZZI, F. MORELLI, GRIECO, PAOLO, J. ROMMELAERE, L. ALOJ, LORIZIO, ROBERTO, M. AURILIO, MAZZARELLA, LELIO, NOVELLINO, ETTORE, OCCHIELLO, ANTONELLA, PICA, ALESSANDRA, PUCCI, PIETRO, R. MANCINI, SICA, ALESSANDRO, SICA, FILOMENA   +17 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source