Results 61 to 70 of about 108,551 (297)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Effect of Ascorbic Acid on Signaling Pathways of Bcl2 and Bax Genes in AGS Cell Line

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2020
Introduction: Antioxidants have a great influence on the control of oxidative stress and free radicals; moreover, they cause the expression of apoptosis genes. Accordingly, they have an important role in preventing cancer.
yaser Asefi, Saeid Ghorbian
doaj  

Detection of BCL2 Rearrangements in Follicular Lymphoma [PDF]

The American Journal of Pathology, 2002
The identification and characterization of recurrent chromosomal translocations has improved tumor classification and yielded numerous insights into tumor pathogenesis, as such events typically lead to the dysregulation of proteins that control critical cellular processes, such as apoptosis, proliferation, differentiation, and immortalization.
Jon C, Aster, Janina A, Longtine
openaire   +2 more sources

Targeted BCL2 inhibition effectively inhibits neuroblastoma tumour growth [PDF]

, 2012
Genomic aberrations of key regulators of the apoptotic pathway have hardly been identified in neuroblastoma. We detected high BCL2 mRNA and protein levels in the majority of neuroblastoma tumours by Affymetrix expression profiling and Tissue Micro Array ...
Versteeg, Rogier, Øra, Ingrid, Schild, Linda, Koster, Jan, Westerhout, Ellen M., Lamers, Fieke, Øra, Ingrid,, Ebus, Marli E., Caron, Huib N., Molenaar, Jan J., Ora, Ingrid, Lund University., den Hartog, Ilona J.M., den Hartog, Ilona J. M.   +13 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

EFFECT OF BEE VENOM AND OTHER NATURAL PRODUCT (LICORICE) ON BAX AND BCL-2 GENE EXPRESSION IN MCF-7 ON BREAST CANCER: AN IN VITRO TRIAL [PDF]

Journal of the Egyptian Society of Parasitology
Bee venom has special pharmacological activity through its complex protein structure which containsenzymes and peptides. Melittin is the bee venom’s major component constituting about 50-70% of its content. Studies showed that bee venom has a huge impact
MARWA ISMAEL, MOHAMED EL-BASSIONY, HATEM MAHFOUZ, ABIR EL-FIKY   +3 more
doaj   +1 more source

BCL2-CISD2 [PDF]

Autophagy, 2012
CISD2, an ER BCL2-associated autophagy regulator also known as NAF-1, is responsible for the human degenerative disorder Wolfram Syndrome 2. In order to interrogate the physiological role of CISD2 we generated and characterized the Cisd2 gene deletion in mice.
Chang, N.C., Nguyen, M., Shore, G.C.
openaire   +3 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Effect of the Adiantum capillus Veneris Extract on Bax and Bcl2 Apoptotic Markers of Lung Modulation in Trained Rats and Exposed to Hypoxic Stress

Journal of Medicinal Plants, 2017
Background: Apoptosis is a type of programmed cell death that occurs by a series of Intercellular messages under Specific conditions. Objective: The aim of present study was investigat role of the Adiantum capillus veneris extract on modulation of Bax ...
M Yadegari, S Riahy, Sh Mirdar, GhR Hamidian, P Mosadegh zavaragh   +4 more
doaj