Results 51 to 60 of about 146,281 (306)

Methanol leaf extract of Azadirachta indica mitigates isoproterenol-induced myocardial infarction through the modulation of oxidative stress, and PPARα and BCL2 signaling in rats [PDF]

Avicenna Journal of Phytomedicine
Objective: Evaluation of Azadirachta indica’s potential on the modulation of blood pressure parameters, antioxidant defense status, as well as immunohistochemical expressions of Peroxisome proliferator-activated receptor α (PPARα) and Bcl-2 (B-cell ...
Amirah Yusuf, Temitayo Ajibade, Oluwaseun Esan, Racheal Asenuga, Moyinoluwa Onoja, Matthew Akpan, Joseph Badejo, Temidayo Omobowale, Ademola Oyagbemi, Adeolu Adedapo, Oluwafemi Oguntibeju, Momoh Yakubu   +11 more
doaj   +1 more source

The in vitro Effect of Doxorubicine-G2-FA Treatment on Breast Cancer Copyright [PDF]

Iranian Journal of Veterinary Medicine, 2020
BACKGROUND: To achieve delivery of a drug to tumors, folic acid (FA) was used as a targeting ligand to change nanocarriers. Since the folate receptor has more expression in several tumor types such as breast cancer. OBJECTIVES: The present study aimed to
Hamed Mansoor Lakooraj, Zohreh Khaki, Masoud Ghorbani, Mehdi Shafiee Ardestani, Omid Dezfoulian   +4 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

miR-424-5p regulates apoptosis and cell proliferation via targeting Bcl2 in nucleus pulposus cells

Animal Cells and Systems, 2020
Background miRNAs play an important role in the pathogenesis of intervertebral disc degeneration (IDD). The role and the underlying mechanism of miR-424-5p in human nucleus pulposus (NP) are still unknown.
Hua-tuo Lu, Yong-qing Xu, Hai Wang, Xu-lin Zhang   +3 more
doaj   +1 more source

The transcription factor ATF5: role in cellular differentiation, stress responses, and cancer. [PDF]

, 2017
Activating transcription factor 5 (ATF5) is a cellular prosurvival transcription factor within the basic leucine zipper (bZip) family that is involved in cellular differentiation and promotes cellular adaptation to stress.
Angelastro, James M, Sears, Thomas K
core   +2 more sources

Cx43 channels and signaling via IP3/Ca2+, ATP, and ROS/NO propagate radiation-induced DNA damage to non-irradiated brain microvascular endothelial cells [PDF]

, 2020
Radiotherapeutic treatment consists of targeted application of radiation beams to a tumor but exposure of surrounding healthy tissue is inevitable.
Bultynck, Geert, De Bock, Marijke, De Smet, Maarten, Decrock, Elke, Delvaeye, Tinneke, Descamps, Benedicte, Hoorelbeke, Delphine, Krysko, Dmitri, Leybaert, Luc, Van Haver, Valérie, Vanhove, Christian   +10 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Autophagy processes are dependent on EGF receptor signaling [PDF]

, 2018
Autophagy is a not well-understood conserved mechanism activated during nutritional deprivation in order to maintain cellular homeostasis. In the present study, we investigated the correlations between autophagy, apoptosis and the MAPK pathways in ...
Capodifoglio, Sabrina, Caruso, Marika, Conti, Pio, Flati, Vincenzo, Iuliis, Vincenzo De, Lanuti, Paola, Marino, Antonio, Marricareda, Valeria, Martinotti, Stefano, Marynuk, Anna, Talora, Claudio, Toniato, Elena, Ursi, Sebastiano   +12 more
core   +1 more source

BCL2 Regulates Differentiation of Intestinal Fibroblasts [PDF]

Inflammatory Bowel Diseases, 2018
Fibrosis in patients with Crohn's disease (CD) results from an imbalance toward excessive fibrous tissue formation driven by fibroblasts. Activation of fibroblasts is linked to the B-cell lymphoma 2 (BCL2) family, which is involved in the induction of apoptosis.
Weder, Bruce, Mamie, Céline, Rogler, Gerhard, Clarke, Stephen, McRae, Bradford, Ruiz, Pedro A, Hausmann, Martin   +6 more
openaire   +3 more sources