Results 51 to 60 of about 91,646 (261)

Combination of Spirulina platensis powder and Stichopus variegatus powder against Bcl2 expression in the hippocampus of dementia Rats [PDF]

Pharmaciana
Spirulina (Spirulina platensis) and golden sea cucumber (Stichopus variegatus) are known to have antioxidant activity that has the potential to prevent neurodegeneration disease.
Lisa Agustina Botutihe, Rizka Safira, Sapto Yuliani, Kintoko   +3 more
doaj   +1 more source

miR-424-5p regulates apoptosis and cell proliferation via targeting Bcl2 in nucleus pulposus cells

Animal Cells and Systems, 2020
Background miRNAs play an important role in the pathogenesis of intervertebral disc degeneration (IDD). The role and the underlying mechanism of miR-424-5p in human nucleus pulposus (NP) are still unknown.
Hua-tuo Lu, Yong-qing Xu, Hai Wang, Xu-lin Zhang   +3 more
doaj   +1 more source

The in vitro Effect of Doxorubicine-G2-FA Treatment on Breast Cancer Copyright [PDF]

Iranian Journal of Veterinary Medicine, 2020
BACKGROUND: To achieve delivery of a drug to tumors, folic acid (FA) was used as a targeting ligand to change nanocarriers. Since the folate receptor has more expression in several tumor types such as breast cancer. OBJECTIVES: The present study aimed to
Hamed Mansoor Lakooraj, Zohreh Khaki, Masoud Ghorbani, Mehdi Shafiee Ardestani, Omid Dezfoulian   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Molecular evaluation of the anticancer potential of 1,3,4-oxadiazole-2-thiones derivative and its synergetic action with Nigella sativa seed extract (Thymoquinone) in experimentally induced Murine Lung Cancer Cell Line Model. [PDF]

Journal of Medical and Life Science
Lung cancer persistently poses as a primary factor in cancer-linked deaths globally, necessitating novel treatment strategies. This investigation appraises the anti-tumor potential of Thymoquinone (TQ) and 1,3,4-oxadiazole derivatives independently and ...
Abdel Aziz Zidane, Elsayed Mahmoud, Mahmoud Tarek, El-Hassan Mokhamer   +3 more
doaj   +1 more source

Detection of BCL2 Rearrangements in Follicular Lymphoma [PDF]

The American Journal of Pathology, 2002
The identification and characterization of recurrent chromosomal translocations has improved tumor classification and yielded numerous insights into tumor pathogenesis, as such events typically lead to the dysregulation of proteins that control critical cellular processes, such as apoptosis, proliferation, differentiation, and immortalization.
Jon C, Aster, Janina A, Longtine
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Effect of Ascorbic Acid on Signaling Pathways of Bcl2 and Bax Genes in AGS Cell Line

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2020
Introduction: Antioxidants have a great influence on the control of oxidative stress and free radicals; moreover, they cause the expression of apoptosis genes. Accordingly, they have an important role in preventing cancer.
yaser Asefi, Saeid Ghorbian
doaj  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

EFFECT OF BEE VENOM AND OTHER NATURAL PRODUCT (LICORICE) ON BAX AND BCL-2 GENE EXPRESSION IN MCF-7 ON BREAST CANCER: AN IN VITRO TRIAL [PDF]

Journal of the Egyptian Society of Parasitology
Bee venom has special pharmacological activity through its complex protein structure which containsenzymes and peptides. Melittin is the bee venom’s major component constituting about 50-70% of its content. Studies showed that bee venom has a huge impact
MARWA ISMAEL, MOHAMED EL-BASSIONY, HATEM MAHFOUZ, ABIR EL-FIKY   +3 more
doaj   +1 more source