Results 221 to 230 of about 134,892 (289)

Molecular and clinical insights into HIV-associated and HIV-negative aggressive B-cell lymphomas: prognostic quantitative biomarker analysis and therapeutic implications. [PDF]

Front Oncol
Liu L, Wang T, Luo J, Huang J, Huang K, Chen K, Wang C, Cheng Z.   +7 more
europepmc   +1 more source

Liquid Biopsy for Enhanced Specificity in Identifying Somatic Mutations in Aggressive Non‐Hodgkin Large B‐Cell Lymphoma: A Comparative Study of Cell‐Free DNA and Formalin‐Fixed Paraffin‐Embedded Tissue

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Formalin‐fixed paraffin‐embedded (FFPE) tumor biopsy is the current mainstay of genotyping, but is limited by its invasiveness and tumor heterogeneity. Plasma cell‐free DNA (cfDNA) constitutes a minimally invasive alternative that may better capture tumor‐derived profiles from circulating tumor DNA (ctDNA). This study compares the
Gayaththri Vimalathas, Oriane Cédile, Marie Louise Grube Kjeldsen, Mads Thomassen, Michael Boe Møller, Charlotte Guldborg Nyvold, Marcus Høy Hansen, Thomas Stauffer Larsen   +7 more
wiley   +1 more source

Clinico-pathologic Profile of Filipino Patients Diagnosed with Diffuse Large B-Cell Lymphoma, Germinal Center or Non-germinal Center Subtype Treated in a Public Tertiary Hospital from 2016 to 2021. [PDF]

Acta Med Philipp
Cancio JEG, Damian KB, Villanueva EQ, Lucero JAC, Talavera ERF.   +4 more
europepmc   +1 more source

A new method to measure cell metabolism of rare cells in vivo reveals a high oxidative phosphorylation dependence of lung T cells

Immunology &Cell Biology, EarlyView.
In this article, we adapted the SCENITH assay to measure the metabolism of rare cells in vivo. We observed that, under steady‐state conditions, lung T cells were highly dependent on oxidative phosphorylation for energy production. Further, metabolic inhibitors that interfere with protein translation and energy availability downregulated Foxp3 ...
Aristeidis Roubanis, Morgane Hilaire, Morgane Le Teuff, Odile Devergne, Tim Sparwasser, Luciana Berod, Benoît L Salomon   +6 more
wiley   +1 more source

TET1 mitigates prenatal fluoride-induced cognition impairment by modulating Bcl2 DNA hydroxymethylation level. [PDF]

Mol Med
Cai Y, Zeng X, Wu M, Chen H, Sun M, Yang H.   +5 more
europepmc   +1 more source

Outcomes of allogeneic haemopoietic transplant for chronic lymphocytic leukaemia in the modern era

Internal Medicine Journal, EarlyView.
Abstract Background Allogeneic haemopoietic stem cell transplantation (HSCT) is an effective therapy with curative potential for patients with high‐risk or relapsed/refractory chronic lymphocytic leukaemia (CLL). There are limited data on the use and outcomes of HSCT in the modern era of CLL treatment.
Luani Barge, Steven Tran, Glen Kennedy, David Ritchie, David Gottlieb, Sam Milliken, Andrew Spencer, Duncan Purtill, Travis Perera, Richard Doocey, Stephen Larsen, Andrew Butler, Peter Bardy, Matthew Greenwood, Simon Durrant, Cameron Curley, Caroline Stewart, Constantine Tam, Shalini Balendran, Pietro R. Di Ciaccio, Sushrut Patil, Min‐Hi Han, Nada Hamad   +22 more
wiley   +1 more source

Delineation of the Human Germinal Centre Immune Landscape Using Multiplex Imaging Analysis

Immunology, EarlyView.
Human CD4 follicular helper T cells (TFH) are a heterogeneous cell population at the phenotypic, localisation and in situ functional level. The application of complementary methods is a prerequisite for a comprehensive delineation of the immune landscape at the tissue level. ABSTRACT Given the role of follicular immune dynamics, especially the germinal
Spiros Georgakis, Michail Orfanakis, Craig Fenwick, Cloe Brenna, Simon Burgermeister, Helen Lindsay, Giuliana Xavier de Medeiros, Fernanda Romano Bruno, Susan Pereira Ribeiro, Raphael Gottardo, Giuseppe Pantaleo, Constantinos Petrovas   +11 more
wiley   +1 more source

Mechanistic investigation of Shuanghuanglian against infectious bronchitis in chickens: a network pharmacology and molecular dynamics study. [PDF]

Front Vet Sci
You F, Zhang H, Meng L, Li C, Yang Y, Wang Y, Zhao R, Chao L.   +7 more
europepmc   +1 more source

Uhrf1 downregulation promotes β‐cell dedifferentiation by decreasing Foxo1 expression in type 2 diabetes

Journal of Diabetes Investigation, EarlyView.
This finding reveals the important role of Uhrf1 in the β‐cell dedifferentiation of T2D, providing a potential target for its treatment. ABSTRACT Background Islet β‐cell dedifferentiation is a major pathological mechanism of type 2 diabetes (T2D). Forkhead box o1 (Foxo1) is a master regulator of β‐cell dedifferentiation.
Lanfang Fu, Juyun Zhang, Zhu Lin, Xubiao Meng   +3 more
wiley   +1 more source

USP11 Promotes Endothelial Apoptosis-Resistance in Pulmonary Arterial Hypertension by Deubiquitinating HINT3. [PDF]

J Respir Biol Transl Med
Kang BY, Choi J, Tseng V, Zhao Y, Zhao J, Stearman RS, Lam WA, Sueblinvong V, Kopp BT, Passineau MJ, Park C, Lister J, Benza RJ, Jang AJ.   +13 more
europepmc   +1 more source