Results 251 to 260 of about 134,892 (289)

Genetic Subtype‐Based International Prognostic Index Prognostic Model in Diffuse Large B‐Cell Lymphoma

MedComm, Volume 6, Issue 7, July 2025.
1. Genetic subtypes based on molecular subtyping correlated with prognosis in DLBCL. 2. Integrated genetic subtype‐based IPI model revealed prognostic discrimination. 3. New four‐category risk model defined for integrated model showed diverse prognosis.
Lan Mi, Jili Deng, Jiayue Qin, Chen Zhang, Lixia Liu, Shunli Yang, Libin Chen, Hua‐Jun Wu, Haojie Wang, Jun Zhu, Hong Chen, Feng Lou, Shanbo Cao, Yuqin Song, Weiping Liu   +14 more
wiley   +1 more source

Antileukemia efficacy of the dual BCL2/BCL-XL inhibitor AZD0466 in acute lymphoblastic leukemia preclinical models. [PDF]

Blood Adv
Kannan S, Li Y, Baran N, Yang X, Ghotbaldini S, Zhang Tatarata Q, Yoshimura S, Li Z, Hsiao Y, Balachander S, Andersen CL, Cidado J, Yu J, Jain N, Yang JJ, Konopleva M.   +15 more
europepmc   +1 more source

Venetoclax Alone or in Combination With Chemotherapy in Paediatric and Adolescent/Young Adult Patients With Relapsed/Refractory Acute Myeloid Leukaemia

Pediatric Blood &Cancer, Volume 72, Issue 7, July 2025.
ABSTRACT Background Venetoclax is a potent, oral BCL‐2 inhibitor approved as combination therapy for the treatment of adults with newly diagnosed acute myeloid leukaemia (AML) who are ineligible for intensive chemotherapy. This study evaluated the safety and preliminary efficacy of venetoclax alone or combined with chemotherapy in paediatric and ...
Seth E. Karol, Seong L. Khaw, C. Michel Zwaan, Andre Baruchel, Henrique Bittencourt, Todd M. Cooper, Christian Flotho, Christopher Fraser, Christopher J. Forlenza, Kelly C. Goldsmith, Margaret E. Macy, Daniel A. Morgenstern, Maureen M. O'Brien, Arnaud Petit, David S. Ziegler, Dirk Reinhardt, Joseph T. Opferman, Jeffrey E. Rubnitz, Maika Onishi, Diana R. Dunshee, Fengjiao Dunbar, Deeksha Vishwamitra, Jeremy A. Ross, Xin Chen, Kristina Unnebrink, Maja Kammerlander, Ahmed Hamed Salem, Tammy L. Palenski, Gauri Sunkersett, Andrew E. Place   +29 more
wiley   +1 more source

Outcome of high-grade B-cell lymphoma compared with other large B-cell lymphoma after CAR-T rescue: a DESCAR-T LYSA study. [PDF]

Blood Adv
Phina-Ziebin X, Bachy E, Gros FX, Di Blasi R, Herbaux C, Bay JO, Carras S, Bories P, Casasnovas O, Jardin F, Morschhauser F, Guffroy B, Mohty M, Gat E, Calvani J, Parrens MC, Poullot E, Traverse-Glehen A, Roulin L.   +18 more
europepmc   +1 more source

The cardio‐renal‐metabolic role of the nod‐like receptor protein‐3 and senescence‐associated secretory phenotype in early sodium/glucose cotransporter‐2 inhibitor therapy in people with diabetes who have had a myocardial infarction

Diabetic Medicine, Volume 42, Issue 7, July 2025.
Abstract Aims Following an acute myocardial infarction (AMI), individuals with type 2 diabetes (T2DM) have a 2‐to‐3 fold increased risk of mortality compared to those without diabetes, and globally cardiorenal complications account for 50% of diabetes‐related deaths.
M. U. Shah, C. L. Cliff, P. E. Squires, K. Lee, C. E. Hills   +4 more
wiley   +1 more source

Inhibitory Potential and Binding Thermodynamics of Scyllatoxin-Based BH3 Domain Mimetics Targeting Repressor BCL2 Proteins. [PDF]

J Mol Recognit
Amarasiri HADB, Arachchige D, Vince MJK, Holub JM.   +3 more
europepmc   +1 more source

Dual Targeting of Pim and PI3 Kinases in Mature T‐Cell Lymphoma

European Journal of Haematology, Volume 115, Issue 1, Page 82-95, July 2025.
ABSTRACT Provirus Integration site for Moloney leukemia virus (Pim) family members are well‐known oncogenes, with an expression that is restricted to few cell types including hematopoietic cells in adult organisms, making it a promising target for lymphoma treatment.
M. Lohrberg, M. Heber, L. Ries, K. Markus, N. Ksionsko, N. Schmidt, G. Nothnick, L. Thielking, M. O'Neill, S. Martínéz‐González, C. Blanco‐Aparicio, J. Pastor, D. Cunningham, R. Koch   +13 more
wiley   +1 more source

Obesity‐Induced Metabolic Priming Exacerbates SARS‐CoV‐2 Inflammation

Immunology, Volume 175, Issue 3, Page 323-338, July 2025.
Monocytes primed under obesogenic conditions, such as increased FFA levels (i.e., palmitate) exhibit exacerbated gene expression of inflammatory cytokines. The increased proinflammatory response of palmitate‐primed and SARS‐CoV‐2‐infected monocytes is not dependent on glycolytic metabolism but instead on the entry of FFAs into the mitochondria ...
Gustavo Gastão Davanzo, Bianca Gazieri Castelucci, Gabriela Fabiano de Souza, Stéfanie Primon Muraro, Larissa Menezes dos Reis, Isabella Bonilha de Oliveira, José Luís Fachi, João Victor Virgilio‐da‐Silva, Marcelo Rodrigues Berçot, Mariane Font Fernandes, Sarah de Oliveira, Nathalia Vitoria Pereira Araujo, Guilherme Ribeiro, Gisele de Castro, Webster Leonardo Guimarães Costa, Adriana Leandra Santoro, Gabriela Flavia Rodrigues‐Luiz, Helison Rafael P. do Carmo, Ikaro Breder, Marcelo A. Mori, Alessandro S. Farias, Daniel Martins‐de‐Souza, Joseph W. Guarnieri, Douglas C. Wallace, Marco Aurélio Ramirez Vinolo, José Luiz Proença‐Módena, Afshin Beheshti, Andrei C. Sposito, Pedro M. Moraes‐Vieira   +28 more
wiley   +1 more source

Correction: CREB1-BCL2 drives mitochondrial resilience in RAS GAP-dependent breast cancer chemoresistance. [PDF]

Oncogene
Man KF, Darweesh O, Hong J, Thompson A, O'Connor C, Bonaldo C, Melkonyan MN, Sun M, Patel R, Ellisen LW, Robinson T, Song D, Koh SB.   +12 more
europepmc   +1 more source