Results 261 to 270 of about 108,551 (297)
Leukemia, 2005 Gain of chromosome 18q and translocation t(14;18) are] frequently found in B-cell non-Hodgkin's lymphomas (B-NHL). Increased BCL2 transcription and BCL2 protein expression have been suggested to be the result of the gain.
Ola Myklebost, David Mu, Trond Stokke
exaly +2 more sources
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Genes, Chromosomes and Cancer, 1991
AbstractWe report a new class of molecular lesions in the 5′ region of the BCL2 protooncogene when it undergoes a t(14;18) translocation‐associated rearrangement in the major break cluster (MBR) or minor break cluster (MCR) regions. Among 52 tumors assayed for BCL2 rearrangements using the MBR, MCR, and 5′ probes, seven (six with MBR and one with MCR ...
V, Mikraki, M, Ladanyi, R S, Chaganti
openaire +2 more sources
AbstractWe report a new class of molecular lesions in the 5′ region of the BCL2 protooncogene when it undergoes a t(14;18) translocation‐associated rearrangement in the major break cluster (MBR) or minor break cluster (MCR) regions. Among 52 tumors assayed for BCL2 rearrangements using the MBR, MCR, and 5′ probes, seven (six with MBR and one with MCR ...
V, Mikraki, M, Ladanyi, R S, Chaganti
openaire +2 more sources
1995
Abstract Probes for the IgH locus were used to clone t(14; 18) breakpoint DNAs. These DNAs allowed the identification of a transcriptional unit on chromosome 18, which was named bc!2. The bcl2 gene is transcribed by alternative splicing into three mRNAs of different sizes.
James R Bischoff +1 more
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Abstract Probes for the IgH locus were used to clone t(14; 18) breakpoint DNAs. These DNAs allowed the identification of a transcriptional unit on chromosome 18, which was named bc!2. The bcl2 gene is transcribed by alternative splicing into three mRNAs of different sizes.
James R Bischoff +1 more
openaire +1 more source
2008
The Bcl2 family of proteins belong to a peculiar class of proteins regulating apoptosis, cell cycle, differentiation, and autophagy; in oncology, the genes coding for these proteins could not be defined neither as dominant transforming oncogenes (such as myc), nor tumor suppressor genes (such as p53).
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The Bcl2 family of proteins belong to a peculiar class of proteins regulating apoptosis, cell cycle, differentiation, and autophagy; in oncology, the genes coding for these proteins could not be defined neither as dominant transforming oncogenes (such as myc), nor tumor suppressor genes (such as p53).
openaire +3 more sources
Enhancing dendritic cells by inhibiting BCL2
Trends in Cancer, 2023Dendritic cells play an important role in anticancer immunity by exposing T cells to tumor-associated antigens. In a recent study, Zhao et al. show that BCL2 inhibition improves the ability of dendritic cells to present antigen to T cells and activate their antitumor cytotoxicity.
Christopher A G, Booth, Andrew A, Lane
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Venetoclax: Targeting BCL2 in Hematological Cancers
2018Over the last years, targeted anti-cancer therapy with small-molecule inhibitors and antibodies moved to the forefront as a strategy to treat hematological cancers. These novel agents showed outstanding effects in treatment of patients, often irrespective of their underlying genetic features.
Annika, Scheffold +2 more
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Modulation of RNA splicing enhances response to BCL2 inhibition in leukemia
Cancer Cell, 2023Emily Creger, Carine Bossard
exaly