Results 251 to 260 of about 146,281 (306)

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, Volume 16, Issue 5, Page 857-869, May 2026.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

A therapeutic-grade purified exosome system alleviates osteoarthritis by regulating autophagy through the BCL2-Beclin1 axis. [PDF]

J Nanobiotechnology
Zhao G, Yousefi F, Tsukamoto I, Moran S, Behfar A, Evans C, Zhao C.   +6 more
europepmc   +1 more source

COL12A1 rs970547 Polymorphism Predisposes Anterior Cruciate Ligament Injury by Inducing ER Stress and Impairing Fibroblast Function

Advanced Biology, Volume 10, Issue 5, May 2026.
The COL12A1 rs970547(A/A) polymorphism is over‐represented in Chinese male anterior cruciate ligament (ACL) injury patients. This variant destabilizes COL12A1 protein without altering transcript levels, driving compensatory upregulation of other collagen genes and inducing endoplasmic reticulum stress in ACL‐derived fibroblasts.
Wenchuan Zhao, Hong Chen, Junwei Wang, Yixin Li, Rui Chen, Jingyi Zhou   +5 more
wiley   +1 more source

HGBL-NOS presenting as widespread extranodal disease without lymphadenopathy: a case report. [PDF]

Front Oncol
Sayes MF, Sabbah A, Karama A, Allan A, Bader B, Abulihya M.   +5 more
europepmc   +1 more source

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, Volume 13, Issue 26, 8 May 2026.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Chronic lymphocytic leukemia with IGH/BCL2 fusion and clonal heterogeneity: phenotypic and molecular profiling analysis of a rare case. [PDF]

Ann Hematol
Zhang T, Liu D, Ren F, Hao J, Ye F, Chen Y, Qiao B, Zhang Y, Chang J, Wang H, Xu Z.   +10 more
europepmc   +1 more source

Detection of Structural Changes in G-Quadruplex-Forming DNA Oligonucleotides via DNA Methylation Based on Luminol Chemiluminescence Catalyzed by Myoglobin. [PDF]

Biosensors (Basel)
Inaba S, Kawai H, Tomizawa M, Miura D, Tsukakoshi K, Ikebukuro K.   +5 more
europepmc   +1 more source

Network pharmacology, machine learning, and experiments uncover β-sitosterol targeting HSP90AA1 in medicinal-edible black soybean against aging. [PDF]

Front Med (Lausanne)
Jia Y, Yang J, Chen Q, Yang Y, Min W, Luo D.   +5 more
europepmc   +1 more source

Pulsatilla Saponin B4 Alleviates H₂O₂-Induced Oxidative Stress and Apoptosis via the AMPK/Nrf2 Pathway in Bovine Mammary Epithelial Cell Models. [PDF]

Antioxidants (Basel)
Zhang H, Yi S, Ding P, Hao B, Shao D, Wang S.   +5 more
europepmc   +1 more source