Oncoscience, 2015 The decision phase of apoptosis is mainly regulated by the Bcl-2 family, which renders these proteins potential targets for cancer therapy through apoptotic mechanisms. Bcl2 family members have homology clustered within four conserved Bcl2 homology (BH) domains (BH1, BH2, BH3 and BH4). Only the antiapoptotic proteins, such as Bcl2, Bcl-XL, Bcl-w and A1,
Guo Chen, Xingming Deng
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Bcl2 inhibition of mitochondrial DNA repair [PDF]
BMC Cancer, 2015 Accumulation of mitochondrial DNA (mtDNA) damage could enhance the frequency of mitochondrial mutations and promote a variety of mitochondria-related diseases, including cancer. However, the mechanism(s) involved are not fully understood.Quantitative extended length PCR was used to compare mtDNA and nDNA damage in human lung H1299 cells expressing WT ...
Paul W. Doetsch +2 more
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Efficient Delivery of Therapeutic siRNA by Fe3O4 Magnetic Nanoparticles into Oral Cancer Cells
Pharmaceutics, 2019 The incidence of oral cancer is increasing due to smoking, drinking, and human papillomavirus (HPV) infection, while the current treatments are not satisfactory.
Lili Jin +5 more
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The in vitro Effect of Doxorubicine-G2-FA Treatment on Breast Cancer Copyright [PDF]
Iranian Journal of Veterinary Medicine, 2020 BACKGROUND: To achieve delivery of a drug to tumors, folic acid (FA) was used as a targeting ligand to change nanocarriers. Since the folate receptor has more expression in several tumor types such as breast cancer. OBJECTIVES: The present study aimed to
Hamed Mansoor Lakooraj +4 more
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Molecular docking approach to identify potential anticancer agents from Sida cordifolia and Eupatorium triplinervis [PDF]
Journal of Veterinary and Animal Sciences, 2023 Sida cordifolia and Eupatorium triplinervis have been used traditionally for treatment of various ailments. An in-silico study was carried out to identify the interaction between the selected phytocompounds with B-cell lymphoma 2 (Bcl2).
K. Priyanka Menon +3 more
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Quantitative Analysis of Tumor-Specific BCL2 Expression in DLBCL: Refinement of Prognostic Relevance of BCL2 [PDF]
Blood, 2019 Introduction Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma and a heterogeneous disease with a variety of molecular aberrations and diverse clinical outcomes. BCL2 expression has been implicated for a poor prognosis among patients with DLBCL.
A-Neum Lee +16 more
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تأثیر تمرین هوازی با شدت متوسط و زیاد بر بیان ژنهای آپوپتوزی BAX (BCL2 associated X) و BCL2 (B-cell lymphoma 2) میوکارد موش صحرایی پس از کمخونی و خونرسانی مجدد [PDF]
فیزیولوژی ورزشی, 2020 هدف از انجام پژوهش حاضر، تعیین تأثیر تمرین هوازی با شدت متوسط و زیاد بر بیان ژنهای BAX و BCL2 میوکارد موش‌های صحرایی نر پس از کمخونی و خونرسانی مجدد بود. در این پژوهش از 26 سر موش صحرایی ویستار دوماهه با وزن تقریبی 25/25 ± 25/225 گرم استفاده شد.
حامد علی زاده پهلوانی +5 more
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Overexpression of microRNA-16 declines cellular growth, proliferation and induces apoptosis in human breast cancer cells [PDF]
, 2015 MicroRNAs (miRNA) are a large family of small single-stranded RNA molecules found in all multicellular organisms. Early studies have been shown that miRNA are involved in cancer development and progression, and this role can be done by working as an ...
Hafizi, M. +8 more
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Detection of BCL2 Rearrangements in Follicular Lymphoma [PDF]
The American Journal of Pathology, 2002 The identification and characterization of recurrent chromosomal translocations has improved tumor classification and yielded numerous insights into tumor pathogenesis, as such events typically lead to the dysregulation of proteins that control critical cellular processes, such as apoptosis, proliferation, differentiation, and immortalization.
Jon C. Aster, Janina A. Longtine
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Combination of Spirulina platensis powder and Stichopus variegatus powder against Bcl2 expression in the hippocampus of dementia Rats [PDF]
PharmacianaSpirulina (Spirulina platensis) and golden sea cucumber (Stichopus variegatus) are known to have antioxidant activity that has the potential to prevent neurodegeneration disease.
Lisa Agustina Botutihe +3 more
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