Results 11 to 20 of about 108,551 (297)

Quantitative Analysis of Tumor-Specific BCL2 Expression in DLBCL: Refinement of Prognostic Relevance of BCL2 [PDF]

Blood, 2019
Introduction Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma and a heterogeneous disease with a variety of molecular aberrations and diverse clinical outcomes. BCL2 expression has been implicated for a poor prognosis among patients with DLBCL.
Roh, Jin, Cho, Hyungwoo, Yoon, Dok Hyun, Hong, Jung Yong, Lee, A-Neum, Eom, Hyeon Seok, Lee, Hyewon, Park, Weon Seo, Han, Jae Ho, Jeong, Seong Hyun, Park, Joon Seong, Pak, Hyo-Kyung, Kim, So-Woon, Kim, Sang-Yeob, Suh, Cheolwon, Huh, Jooryung, Park, Chan-Sik   +16 more
openaire   +4 more sources

Lack of expression of TUBB3 characterizes both BCL2-positive and BCL2-negative follicular lymphoma [PDF]

Modern Pathology, 2014
Follicular lymphoma is characterized by aberrant BCL2 expression, a feature that is exploited for diagnostic purposes. However, a certain percentage of follicular lymphomas might be BCL2-negative by immunohistochemistry, increasing the difficulties in differentiating them from follicular hyperplasia.
ZAMO', Alberto, Erdini F, MALERBA, Giovanni, CHILOSI, Marco   +3 more
openaire   +5 more sources

The Incomplete Puzzle of the BCL2 Proteins [PDF]

Cells, 2019
The proteins of the BCL2 family are key players in multiple cellular processes, chief amongst them being the regulation of mitochondrial integrity and apoptotic cell death. These proteins establish an intricate interaction network that expands both the cytosol and the surface of organelles to dictate the cell fate.
Hector Flores-Romero, Ana J. García-Sáez   +1 more
openaire   +6 more sources

BCL2 Regulates Differentiation of Intestinal Fibroblasts [PDF]

Inflammatory Bowel Diseases, 2018
Background Fibrosis in patients with Crohn's disease (CD) results from an imbalance toward excessive fibrous tissue formation driven by fibroblasts. Activation of fibroblasts is linked to the B-cell lymphoma 2 (BCL2) family, which is involved in the induction of apoptosis. We investigated the impact of BCL2 repression on fibrogenesis. Methods The model
Weder, Bruce, Mamie, Céline, Rogler, Gerhard, Clarke, Stephen, McRae, Bradford, Ruiz, Pedro A, Hausmann, Martin   +6 more
openaire   +6 more sources

Targeted inhibition of DHODH is synergistic with BCL2 blockade in HGBCL with concurrent MYC and BCL2 rearrangement

BMC Cancer
AbstractHigh-grade B-cell lymphoma (HGBCL), the subtype of non-Hodgkin lymphoma, to be relapsed or refractory in patients after initial therapy or salvage chemotherapy. Dual dysregulation of MYC and BCL2 is one of the important pathogenic mechanisms. Thus, combined targeting of MYC and BCL2 appears to be a promising strategy.
Lin Liu, Wenbin Mo, Miao Chen, Yi Qu, Pingping Wang, Ying Liang, Xiaojing Yan   +6 more
openaire   +4 more sources

MiR-4328 inhibits proliferation, metastasis and induces apoptosis in keloid fibroblasts by targeting BCL2 expression

Open Life Sciences, 2020
Keloids are considered to be a type of benign tumor. MicroRNAs have been reported to be involved in the formation and growth of keloids. MicroRNA-4328 (miR-4328) was found to be abnormally expressed in keloids, while the role and the detailed molecular ...
Tang Hongmei, Chen Qi, Yu Wenyuan, Zhao Tianlan   +3 more
doaj   +1 more source

The effect of training on mitochondrial mitophagy factors in obese male rats [PDF]

فیزیولوژی ورزش و فعالیت بدنی, 2022
purpose: Mitophagy can assist in mitochondrial quality control. The aim of this study was to investigate the effect of training on mitochondrial mitophagy factors in obese male rats.Methods: In this experimental study, 40 male rats (weight 120 ± 20 g ...
Mozhgan Ahmadi, Neda Aghaei Bahman Begloo   +1 more
doaj   +1 more source

Solitary Fibrous Tumour of the Clavicle: A Rare Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2016
A Solitary Fibrous Tumour (SFT) is the preferred term by most of the pathologists than “haemangiopericytoma”. SFT is a heterogeneous group of benign and malignant neoplasms along a morphologic continuum. Here we report a case of SFT of the clavicle in a
Dileep Krishnamoorty Srinivas, Arjun Ballal, Mukta Pai, Kushalappa Subbiah, H. Ravindranath Rai   +4 more
doaj   +1 more source

Post-Transcriptional Regulation of BCL2 mRNA by the RNA-Binding Protein ZFP36L1 in Malignant B Cells [PDF]

, 2014
The human ZFP36 zinc finger protein family consists of ZFP36, ZFP36L1, and ZFP36L2. These proteins regulate various cellular processes, including cell apoptosis, by binding to adenine uridine rich elements in the 3? untranslated regions of sets of target
Fei, P, Norton, JD, Anna Zekavati, Aldrovandi Maceler, Alcaraz, A, Murphy John J., Norton John D., Nasir, A., Alcaraz, A., Norton, J.D., Aldrovandi, M., Alcaraz Amor, Nasir, A, John J Murphy, Amor Alcaraz (597020), Maceler Aldrovandi (597021), Murphy, JJ, Marsh, P., John D Norton, Anna Zekavati (108756), Phil Marsh (597022), Amor Alcaraz, Zekavati, A., Zekavati, A, Marsh, P, Maceler Aldrovandi, Phil Marsh, John D. Norton (108750), John J. Murphy (108765), Zekavati Anna, Nasir Asghar, Asghar Nasir, Marsh Phil, Murphy, J.J., Asghar Nasir (108748), Aldrovandi, M   +35 more
core   +2 more sources

Venetoclax inhibits autophagy in chronic lymphocytic leukemia cells

Autophagy Reports, 2023
Venetoclax (VCX) is a BCL2 inhibitor approved for treating B cell-derived leukemia, including chronic lymphocytic leukemia (CLL). VCX’s role in apoptosis induction is well-defined, whereas its other mechanistic roles need to be clarified. Autophagy is an
Yongqiang Chen, Sara E. F. Kost, Xiaoyan Yang, Versha Banerji, James B. Johnston, Sachin Katyal, Spencer B. Gibson   +6 more
doaj   +1 more source