Results 51 to 60 of about 145,113 (281)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

miR-424-5p regulates apoptosis and cell proliferation via targeting Bcl2 in nucleus pulposus cells

Animal Cells and Systems, 2020
Background miRNAs play an important role in the pathogenesis of intervertebral disc degeneration (IDD). The role and the underlying mechanism of miR-424-5p in human nucleus pulposus (NP) are still unknown.
Hua-tuo Lu, Yong-qing Xu, Hai Wang, Xu-lin Zhang   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Cell death and life in cancer: mathematical modeling of cell fate decisions

, 2011
Tumor development is characterized by a compromised balance between cell life and death decision mechanisms, which are tighly regulated in normal cells.
Barillot, Emmanuel, Calzone, Laurence, Fourquet, Simon, Tournier, Laurent, Zinovyev, Andrei   +4 more
core   +2 more sources

Overexpression of an activated REL mutant enhances the transformed state of the human B-lymphoma BJAB cell line and alters its gene expression profile [PDF]

, 2009
The human REL proto-oncogene encodes a transcription factor in the nuclear factor (NF)-kappaB family. Overexpression of REL is acutely transforming in chicken lymphoid cells, but has not been shown to transform any mammalian lymphoid cell type.
Chin, M., Gilmore, T.D., Herscovitch, M., Waxman, D.J., Zhang, N.   +4 more
core   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Genomic studies indicate a novel combination therapy for follicular lymphoma

Molecular & Cellular Oncology, 2021
Follicular lymphoma (FL) is an incurable form of B-cell lymphoma. Genomic alterations that inactivate RB signaling are surprisingly common in indolent FL. We show that FLs that are positive for phosphorylated RB respond to dual CDK4/BCL2 inhibition.
Elisa Oricchio, Hans-Guido Wendel
doaj   +1 more source

تأثیر تمرین هوازی با شدت متوسط و زیاد بر بیان ژن‌های آپوپتوزی BAX (BCL2 associated X) و BCL2 (B-cell lymphoma 2) میوکارد موش صحرایی پس از کم‌خونی و خون‌رسانی مجدد [PDF]

فیزیولوژی ورزشی, 2020
هدف از انجام پژوهش حاضر، تعیین تأثیر تمرین هوازی با شدت متوسط و زیاد بر بیان ژن­های BAX و BCL2 میوکارد موش‌های صحرایی نر پس از کم­خونی و خون­رسانی مجدد بود. در این پژوهش از 26 سر موش صحرایی ویستار دوماهه با وزن تقریبی 25/25 ± 25/225 گرم استفاده شد.
حامد علی زاده پهلوانی, حمید رجبی, محمد نبیونی, پزمان معتمدی, ندا خالدی, اکرم تایانلو   +5 more
doaj   +1 more source

HAGE (DDX43) is a biomarker for poor prognosis and a predictor of chemotherapy response in breast cancer [PDF]

, 2014
Background: HAGE protein is a known immunogenic cancer-specific antigen. Methods: The biological, prognostic and predictive values of HAGE expression was studied using immunohistochemistry in three cohorts of patients with BC (n=2147): early primary (EP ...
A G Pockley, AC Wolff, AJ Linley, C Denkert, C Johnson, C Lurquin, CJ Piyathilake, CW Elston, DR Germain, E Dotan, E Yakirevich, EF Velazquez, G Qu, G R Ball, I O Ellis, J Kim, J Roman-Gomez, J Soares, JP Issa, L Harris, L Yang, L Zheng, L Zitvogel, LM McShane, M Clarke, M Otte, ME Hammond, MG Mathieu, MG Mathieu, MO Riener, N Harbeck, NC Wortham, P M Moseley, Q Chen, R C Rees, R Iggo, S E B McArdle, S Gluck, S Shin, S Y T Chan, SE Pinder, SP Adams, T Kurashige, T M A Abdel-Fatah, TM Abdel-Fatah, TM Abdel-Fatah, V Martelange, YI Kim, YT Chen   +48 more
core   +3 more sources