Results 51 to 60 of about 150,149 (335)

Inverting the BTK-BCL2 order [PDF]

Blood, 2020
In this issue of Blood, Lin et al report the first long-term follow-up data showing that Bruton tyrosine kinase inhibitors (BTKi's) are effective in chronic lymphocytic leukemia (CLL) after previous progression on venetoclax.
openaire   +2 more sources

Targeting BCL-2 regulated apoptosis in cancer [PDF]

, 2018
The ability of a cell to undergo mitochondrial apoptosis is governed by pro- and anti-apoptotic members of the BCL-2 protein family. The equilibrium of pro- versus anti-apoptotic BCL-2 proteins ensures appropriate regulation of programmed cell death ...
Campbell, Kirsteen J., Tait, Stephen W.J.   +1 more
core   +1 more source

Prevalence and Prognostic Impact of MYC, BCL2, and BCL6 Rearrangements in Large B Cell Lymphoma Patients: A Multicenter Historical Cohort Study from Iran [PDF]

Middle East Journal of Cancer
Background: Diffuse large B cell lymphoma (DLBCL) is the most prevalent subtype of non-Hodgkin's lymphoma, characterized by remarkable molecular heterogeneity.
Fatemeh Radmanesh, Ahmad Monabati, Maedeh Motavas, Alireza Rezvani, Mehdi Montazer   +4 more
doaj   +1 more source

BAX/BCL2 ratio in chronic lymphocytic leukemia and its association with ZAP-70 expression and other clinicopathological parameters

Iraqi Journal of Hematology, 2020
BACKGROUND: Chronic lymphocytic leukemia (CLL) is a heterogeneous disease with a highly variable clinical course and outcome. Many clinical and biological characteristics have been used to classify patients with CLL into different subgroups of variable ...
Rihab Malik Rahid, Maysem Mouayad Alwash
doaj   +1 more source

Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system [PDF]

, 2013
It has long been recognized that the T-cell compartment has more CD4 helper than CD8 cytotoxic T cells, and this is most evident looking at T-cell development in the thymus.
Bains, Iren, Seddon, Benedict, Sinclair, Charles, Yates, Andrew J.   +3 more
core   +1 more source

BCL2L1 (BCL2-like 1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on BCL2L1 (BCL2-like 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Varna, M, Ratajczak, P, Bertheau, P, Janin, A   +3 more
openaire   +2 more sources

تأثیر تمرین هوازی با شدت متوسط و زیاد بر بیان ژن‌های آپوپتوزی BAX (BCL2 associated X) و BCL2 (B-cell lymphoma 2) میوکارد موش صحرایی پس از کم‌خونی و خون‌رسانی مجدد [PDF]

فیزیولوژی ورزشی, 2020
هدف از انجام پژوهش حاضر، تعیین تأثیر تمرین هوازی با شدت متوسط و زیاد بر بیان ژن­های BAX و BCL2 میوکارد موش‌های صحرایی نر پس از کم­خونی و خون­رسانی مجدد بود. در این پژوهش از 26 سر موش صحرایی ویستار دوماهه با وزن تقریبی 25/25 ± 25/225 گرم استفاده شد.
حامد علی زاده پهلوانی, حمید رجبی, محمد نبیونی, پزمان معتمدی, ندا خالدی, اکرم تایانلو   +5 more
doaj   +1 more source

Transcriptome analysis of ABCB1, ABCG2 and the BCL2/BAX ratio in refractory and relapsed canine lymphomas under treatment and rescue protocol

Acta Veterinaria, 2018
The main problems that cause unresponsiveness to an anti-neoplastic drug are the overexpression of drug resistant and anti-apoptotic proteins in tumor cells.
Sirivisoot Sirintra, Teewasutrakul Patharakrit, Rungsipipat Anudep, Tangkawattana Sirikachorn, Techangamsuwan Somporn   +4 more
doaj   +1 more source

Efficient Delivery of Therapeutic siRNA by Fe₃O₄ Magnetic Nanoparticles into Oral Cancer Cells

Pharmaceutics, 2019
The incidence of oral cancer is increasing due to smoking, drinking, and human papillomavirus (HPV) infection, while the current treatments are not satisfactory.
Lili Jin, Qiuyu Wang, Jiayu Chen, Zixiang Wang, Hongchuan Xin, Dianbao Zhang   +5 more
doaj   +1 more source

miR-424-5p regulates apoptosis and cell proliferation via targeting Bcl2 in nucleus pulposus cells

Animal Cells and Systems, 2020
Background miRNAs play an important role in the pathogenesis of intervertebral disc degeneration (IDD). The role and the underlying mechanism of miR-424-5p in human nucleus pulposus (NP) are still unknown.
Hua-tuo Lu, Yong-qing Xu, Hai Wang, Xu-lin Zhang   +3 more
doaj   +1 more source