Results 61 to 70 of about 145,113 (281)

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Autophagy processes are dependent on EGF receptor signaling [PDF]

, 2018
Autophagy is a not well-understood conserved mechanism activated during nutritional deprivation in order to maintain cellular homeostasis. In the present study, we investigated the correlations between autophagy, apoptosis and the MAPK pathways in ...
Capodifoglio, Sabrina, Caruso, Marika, Conti, Pio, Flati, Vincenzo, Iuliis, Vincenzo De, Lanuti, Paola, Marino, Antonio, Marricareda, Valeria, Martinotti, Stefano, Marynuk, Anna, Talora, Claudio, Toniato, Elena, Ursi, Sebastiano   +12 more
core   +1 more source

BCL2 Regulates Differentiation of Intestinal Fibroblasts [PDF]

Inflammatory Bowel Diseases, 2018
Fibrosis in patients with Crohn's disease (CD) results from an imbalance toward excessive fibrous tissue formation driven by fibroblasts. Activation of fibroblasts is linked to the B-cell lymphoma 2 (BCL2) family, which is involved in the induction of apoptosis.
Weder, Bruce, Mamie, Céline, Rogler, Gerhard, Clarke, Stephen, McRae, Bradford, Ruiz, Pedro A, Hausmann, Martin   +6 more
openaire   +3 more sources

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Functional role and tobacco smoking effects on methylation of CYP1A1 gene in prostate cancer. [PDF]

, 2016
Cytochrome P450 (CYP) 1A1 is a phase I enzyme that can activate various compounds into reactive forms and thus, may contribute to carcinogenesis. In this study, we investigated the expression, methylation status, and functional role of CYP1A1 on prostate
Chang, Inik, Dahiya, Rajvir, Deng, Guoren, Fukuhara, Shinichiro, Hashimoto, Yutaka, Imai-Sumida, Mitsuho, Kato, Taku, Majid, Shahana, Mitsui, Yozo, Nakajima, Koichi, Saini, Sharanjot, Shiina, Hiroaki, Shiina, Marisa, Tanaka, Yuichiro, Wong, Darryn K, Yamamura, Soichiro   +15 more
core   +1 more source

BCL2 genotypes and prostate cancer survival [PDF]

Strahlentherapie und Onkologie, 2017
The antiapoptotic B‑cell lymphoma 2 (BCL2) gene is a key player in cancer development and progression. A functional single-nucleotide polymorphism (c.-938C>A, rs2279115) in the inhibitory P2 BCL2 gene promoter has been associated with clinical outcomes in various types of cancer. Aim of the present study was to analyze the role of BCL2-938C>A genotypes
Wilfried Renner, Uwe Langsenlehner, Sabine Krenn-Pilko, Petra Eder, Tanja Langsenlehner   +4 more
openaire   +2 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Modeling a Data Mining Decision Tree and Propose a New Model for the Diagnosis of Skin Cancer by Immunohistochemical Staining Methods

مجله انفورماتیک سلامت و زیست پزشکی, 2014
Introduction: New diagnostic methods like immunohistochemistry staining in skin cancer can help the physicians to have more accurate diagnosis. The purpose of this study was to compare a method based on decision tree for differential diagnosis of two ...
Afshin Sarafi Nejad, Amirhossein Saeid, Isa Mohammed Rose, Alireza Rowhanimanesh   +3 more
doaj  

TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer. [PDF]

, 2016
A subgroup of breast cancers has several metabolic compartments. The mechanisms by which metabolic compartmentalization develop in tumors are poorly characterized. TP53 inducible glycolysis and apoptosis regulator (TIGAR) is a bisphosphatase that reduces
Bartrons, Ramon, Birbe, Ruth C., Capparelli, Claudia, Caro, Jaime, Curry, Joseph M., Domingo-Vidal, Marina, Ko, Ying-Hui, Lin, Zhao, Manzano, Anna, Martinez-Outshoorn, Ubaldo E., Navarro-Sabaté, Àurea, Roche, Megan, Seifert, Erin, Tassone, Patrick, Tuluc, Madalina, Whitaker-Menezes, Diana   +15 more
core   +2 more sources

BAG1 (BCL2-associated athanogene) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on BAG1 (BCL2-associated athanogene), with data on DNA, on the protein encoded, and where the gene is implicated.
Southern, SL, Skeen, V, Williams, AC
openaire   +2 more sources