Results 61 to 70 of about 134,892 (289)

Genomic studies indicate a novel combination therapy for follicular lymphoma

Molecular & Cellular Oncology, 2021
Follicular lymphoma (FL) is an incurable form of B-cell lymphoma. Genomic alterations that inactivate RB signaling are surprisingly common in indolent FL. We show that FLs that are positive for phosphorylated RB respond to dual CDK4/BCL2 inhibition.
Elisa Oricchio, Hans-Guido Wendel
doaj   +1 more source

MicroRNAs targeting oncogenes are down-regulated in pancreatic malignant transformation from benign tumors [PDF]

, 2012
BACKGROUND MicroRNA (miRNA) expression profiles have been described in pancreatic ductal adenocarcinoma (PDAC), but these have not been compared with pre-malignant pancreatic tumors.
A Cimmino, A Grimson, A Keller, A Lal, A Singh, Adam E. Frampton, AE Szafranska, AE Szafranska, AL Warshaw, AM Bellizzi, AM Krichevsky, AN Bartley, Andreas Keller, BM Bolstad, C Almoguera, C Galanis, C Mayr, C Stefano, D Bartsch, D Bonci, DS Klimstra, DV Sahani, F Takeshita, FA Sinicrope, G Garcea, GA Calin, Georgios Giamas, GK Smyth, GK Smyth, H Matthaei, H Wang, J Lu, J Meister, J Torrisani, J Yu, Jimmy Jacob, Jonathan Krell, JS Desgrosellier, JS Oh, Justin Stebbing, K Izeradjene, K Ohuchida, K Satoh, K Yoshizawa, KC Miranda, L Castellano, L Xia, Leandro Castellano, Long R. Jiao, Loredana Pellegrino, M Bloomston, M Crawford, M Dillhoff, M Fabbri, M Goggins, M Seux, M Tanaka, Marc Tjwa, MC du Rieu, N Abe, N Habbe, Nagy A. Habib, Nicole Tsim, O Basturk, OA Kent, Panagiotis Vlavianos, Patrizia Cohen, R Bhattacharya, R Feng, Raida Ahmad, RI Aqeilan, S Griffiths-Jones, S Griffiths-Jones, S Hamada, S Mukherjee, S Reddy, S Vorwerk, S Watanabe, S Yu, SD Selcuklu, SF Tavazoie, SM Johnson, SYG Friedlander, T Ishikawa, T Paranjape, WA Mardin, WG Zhao, WR Brugge, X Chen, X Li, Y Akao, Y Benjamini, Y Hochberg, YJ Chua   +93 more
core   +4 more sources

Apoptotic caspases inhibit abscopal responses to radiation and identify a new prognostic biomarker for breast cancer patients

OncoImmunology, 2019
Caspase 3 (CASP3) has a key role in the execution of apoptosis, and many cancer cells are believed to disable CASP3 as a mechanism of resistance to cytotoxic therapeutics.
Maria Esperanza Rodriguez-Ruiz, Aitziber Buqué, Michal Hensler, Jonathan Chen, Norma Bloy, Giulia Petroni, Ai Sato, Takahiro Yamazaki, Jitka Fucikova, Lorenzo Galluzzi   +9 more
doaj   +1 more source

The influence of BCL2, BAX, and ABCB1 gene expression on prognosis of adult de novo acute myeloid leukemia with normal karyotype patients

Radiology and Oncology, 2023
Deregulation of the apoptotic process underlies the pathogenesis of many cancers, including leukemia, but is also very important for the success of chemotherapy treatment.
Pravdic Zlatko, Vukovic Nada Suvajdzic, Gasic Vladimir, Marjanovic Irena, Karan-Djurasevic Teodora, Pavlovic Sonja, Tosic Natasa   +6 more
doaj   +1 more source

Protein kinase CK2 is widely expressed in follicular, Burkitt and diffuse large B-cell lymphomas and propels malignant B-cell growth. [PDF]

, 2015
Serine-threonine kinase CK2 is highly expressed and pivotal for survival and proliferation in multiple myeloma, chronic lymphocytic leukemia and mantle cell lymphoma.
Agostinelli, C, Benvenuti, P, Casellato, A, Fuligni, F, Mandato, E, Piazza, Francesco, Pileri, Sa, Pizzi, Marco, Rugge, Massimo, Semenzato, Gianpietro Carlo   +9 more
core   +1 more source

Methylation of CpG sites in BCL2 major breakpoint region and the increase of BCL2/JH translocation with aging [PDF]

AGE, 2015
The BCL2 breakage mechanism has been shown to be highly dependent on DNA methylation at the major breakpoint region (MBR) CpG sites. We recently described an increased frequency of BCL2/ JH translocation with aging. It is known that methylation levels change with aging.
Maialen Martin-Arruti, Cristina Garcia-Orad, Africa Garcia-Orad, Irune Ruiz, Iñaki Zabalza, Maite Ardanaz, Elena López de Arana Prado, Isabel Guerra, Idoia Martin-Guerrero   +8 more
openaire   +2 more sources

Amelioration effects of vitamin e, melatonin, l-carnitine, and atorvastatin, on destructive effects of busulfan in the testes of male rats: a gene expression evaluation [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2019
According to toxicity of various types of cancer treatments on different kind of cells with high division activities such as germ cells, antioxidants may protect these cells in testes against the toxic effects of the chemotherapeutic drugs.
Forutan SALEHINEZHAD, Hamidreza ESHRAGHI, Ali KADIVAR, Sadegh SHIRIAN, Ahmad ASGHARI, Ehsan AALI, Najmeh DAVOODIAN   +6 more
doaj   +1 more source

Involvement of Mfn2, Bcl2/Bax signaling and mitochondrial viability in the potential protective effect of Royal jelly against mitochondria-mediated ovarian apoptosis by cisplatin in rats [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): The current study aimed to assess cisplatin-mediated ovarian apoptosis in a rat model by Royal jelly (RJ). Materials and Methods: Thirty female adult albino rats (180-200 g) were divided into three groups (n=10): saline (0.9% NaCl, IP) was ...
khalid Hashem, Asmaa Elkelawy, Saber Abd-Allah, Nermeen Helmy   +3 more
doaj   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

DLBCL-Morph: Morphological features computed using deep learning for an annotated digital DLBCL image set [PDF]

arXiv, 2020
Diffuse Large B-Cell Lymphoma (DLBCL) is the most common non-Hodgkin lymphoma. Though histologically DLBCL shows varying morphologies, no morphologic features have been consistently demonstrated to correlate with prognosis. We present a morphologic analysis of histology sections from 209 DLBCL cases with associated clinical and cytogenetic data ...
arxiv