Results 111 to 120 of about 13,956,044 (136)

β-Casein A1 and A2 Genetic Variants and β-Casomorphin-7 in Raw Milk and Processed Milk Products

International Journal of Molecular Sciences
The A1 and A2 variants of bovine β-casein (CSN2) have gained attention in the dairy industry due to potential health effects. The A1 variant, prevalent in Holstein-Friesian cattle, is a major source of β-casomorphin-7 (BCM-7)—an opioid-like peptide ...
S. Kamiński, A. Cieślińska
semanticscholar   +1 more source

A comparative study of the composition of microorganisms and metabolites in different β-casein genetic types of dairy cows based on metagenomics and non-targeted metabolomics.

Food Research International
β-Casein is the main component of cow's milk protein, with A1 and A2 β-casein being the most common. Of these, A1 β-casein hydrolysate produces BCM-7, which can cause lactose intolerance, while A2 β-casein milk is more gentle on the gut.
Chuan-Chuan Wang, Jinyan Zhao, Wei Zhao, Lin Xue, Yafei Chen, Jia Tian, Hua Wang, Xiaoyun Ji, Xiao-Hua Tian, Juan Zhang, Ya-Ling Gu   +10 more
semanticscholar   +1 more source

Slowdown of BCM plasticity with many synapses [PDF]

Journal of Computational Neuroscience, 2019
During neural development sensory stimulation induces long-term changes in the receptive field of the neurons that encode the stimuli. The Bienenstock-Cooper-Munro (BCM) model was introduced to model and analyze this process computationally, and it ...
Mark Cw van Rossum
exaly   +2 more sources

Estimating β-casomorphin-7 exposure from milk and dairy product consumption: a comprehensive assessment for the European population

International Journal of Food Science and Nutrition
β-Casomorphin-7 (BCM-7), a heptapeptide derived from β-casein hydrolysis, has gained attention for its potential role in gastrointestinal discomfort and certain diseases, yet its effects remain controversial.
Francesca Danesi, Filippo Rossi, G. Leni, Giorgia Antonelli, Alessandra Bordoni, T. Bertuzzi, Mattia Santoni, D. Risso, Federico Canzoneri, R. Menta, M. Dall'Asta   +10 more
semanticscholar   +1 more source

Investigation of A2 allele frequency in Taiwanese Holstein cattle using genetic testing.

Polish journal of veterinary sciences
β-Casein accounts for approximately 30% of total milk protein, with the A1 and A2 variants being the most common. A1 β-casein may release β-casomorphin-7 (BCM-7) during digestion, which is associated with adverse health effects, whereas A2 β-casein does ...
Chun-Hsuan Chao, J. Shiau
semanticscholar   +1 more source

β-Casomorphin: A complete health perspective.

Food Chemistry, 2020
β-Casomorphin-7 (BCM-7) is a heptapeptide dietary molecule derived from the digestion of the β-casein of dairy and dairy products. In this review, we have covered the extensive details about BCM and its derived peptides out of the gastrointestinal and ...
M. Thiruvengadam, Baskar Venkidasamy, P. Thirupathi, I. Chung, U. Subramanian   +4 more
semanticscholar   +1 more source

Biochemical Profiles of High Fat Diet Mice Model with Feeding of Cow Milk representing different beta casein genotypes with reference of A1/A2 allele

Ecology, environment & conservation
Cow’s milk is an essential part of the human diet as it provides vital nutrients and exhibits medicinal properties. It is rich in high-quality proteins, fats, sugars, vitamins, and minerals, with over 95% of its proteins consisting of caseins and whey ...
Preeti, M. Mukesh, Pamela Singh, Shivam Kumar Dubey, G. Bhakri, Anurag Kumar, V. Chaudhary, R. Kataria, S. Niranjan, A. K. Mohanty, M. Sodhi   +10 more
semanticscholar   +1 more source

β-Casomorphins as Opioid Peptide Modulators of Tumor Biology and Immune Signaling.

European Journal of Pharmacology
β-casomorphins (BCMs) are bioactive peptides generated from milk β-casein digestion, which interact with opioid and other receptors to affect both tumor cell proliferation and immune responses within the tumor microenvironment.
Wojciech Kamysz, Krystian Małek, P. Kleczkowska   +2 more
semanticscholar   +1 more source

Effect of bovine beta-casomorphins on rat pancreatic beta cells (RIN-5F) under glucotoxic stress.

Biochemical and Biophysical Research Communications - BBRC
Beta-casomorphins (BCMs) are the bio-active peptides having opioid properties which are formed by the proteolytic digestion of β-caseins in milk. BCM-7 forms when A1 milk is digested in the small intestine due to a histidine at the 67th position in β ...
S. Dubey, A. Thakur, M. Jena, Sudarshan Kumar, M. Sodhi, M. Mukesh, J. Kaushik, A. Mohanty   +7 more
semanticscholar   +1 more source

Release of β-casomorphin-7 from bovine milk of different β-casein variants after ex vivo gastrointestinal digestion

International Dairy Journal, 2018
The release of β-casomorphin-7 (BCM-7) in bovine milk with β-casein genetic variants A1, A2, F and I was assessed. An ex vivo gastrointestinal (GI) digestion model was applied and multiple reaction monitoring method for quantification of BCM-7 was set up
T. Asledottir, Thao T. Le, N. Poulsen, Tove G. Devold, L. B. Larsen, G. Vegarud   +5 more
semanticscholar   +1 more source