Difficulties in Establishing the Adverse Effects of β-Casomorphin-7 Released from β-Casein Variants—A Review [PDF]
Foods, 2023 β-Casomorphin-7 (BCM-7) is a peptide released through the proteolysis of β-casein (β-CN), which is considered a bioactive peptide displaying evidence of promoting the binding and activation of the μ-opioid receptor located in various body parts, such as ...
Ana Maria Centola Vidal +2 more
exaly +4 more sources
β-Casomorphin-7 as a Potential Inflammatory Marker: How β-Casomorphin-7 Induces Endothelial Dysfunction in HUVEC/TERT2 Cell Lines [PDF]
BiomedicinesBackground/Objectives: Endothelial dysfunction plays a central role in the development of cardiovascular diseases. β-Casomorphin-7 (BCM-7), a biologically active peptide generated during the digestion of A1 β-casein, is presumed to contribute to this ...
Judit Rita Homoki +10 more
doaj +2 more sources
β-casomorphin-7: a review of occurrence, identification, techno-functionality, and effects on human health [PDF]
npj Science of Foodβ-casomorphin-7 (βCM-7) is a bioactive peptide released after the digestion of β-casein A1 variant, mostly found in European cow breeds’ milk. This review explores the occurrence, characteristics, identification, techno-functionality, and the potential ...
Abdelmoneim H. Ali +5 more
doaj +2 more sources
Comparative Effects of Milk Containing A1 versus A2 β-Casein on Health, Growth and β-Casomorphin-7 Level in Plasma of Neonatal Dairy Calves [PDF]
Animals, 2020 Research has shown that digestion of A1 β-casein (β-CN) affects gastrointestinal motility and opioid activity through the release of the peptide β-casomorphin-7 (β-CM7).
Lisa G. Hohmann +5 more
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Differential Release of β-Casomorphins from A1 and A2 Milk During Standardized Gastrointestinal Digestion Quantified by CE–MS [PDF]
Foodsβ-Casein A1 and A2 (β-CN-A1 and β-CN-A2) are the two predominant β-CN proteoforms in bovine milk. β-CN-A1 has been associated with a greater propensity to release opioid peptides, such as β-casomorphin-7 (β-CM-7) and β-casomorphin-5 (β-CM-5), during ...
Tahereh Tehrani +5 more
doaj +2 more sources
Influence of the β-Casein Genotype of Cow’s Milk (A1, A2) on the Quality and β-Casomorphin-7 (BCM-7) Content of a Semi-Hard Cheese During Production [PDF]
FoodsCow’s milk contains A1- and A2-β-caseins. The breakdown of A1-β-casein produces β-casomorphin-7 (BCM-7), a peptide with opioid-like properties that is associated with health aspects.
Louisa Zinßius +5 more
doaj +2 more sources
Significance of CD10 for Mucosal Immunomodulation by β-Casomorphin-7 in Exacerbation of Ulcerative Colitis [PDF]
Current Issues in Molecular Biologyβ-Casomorphin-7 (BCM), a breakdown product of milk β-casein, exhibits opioid activity. Opioids are known to affect the immune system, but the effects of BCM on ulcerative colitis (UC) are not clear.
Yoshihiro Miyagawa +9 more
doaj +2 more sources
Effects of A1 Milk, A2 Milk and the Opioid-like Peptide β-Casomorphin-7 on the Proliferation of Human Peripheral Blood Mononuclear Cells [PDF]
BiomoleculesSpecial attention is given to cow’s milk and its variants, with ongoing discussions about health-related impacts primarily focusing on the A1 variant in contrast to the A2 variant.
Felix Gard +4 more
doaj +2 more sources
Effects of β-casein A1/A2 milk and β- and κ-casein genotypes on the performance, body composition, and fecal score of dairy calves [PDF]
Scientific ReportsThe perceived health benefits of β-casein (β-CN) A2 milk for humans have driven increased selection for homozygous β-CN A2 dairy cattle. However, little is known about the effects of feeding milk with different β-CN variants to calves, or about the ...
R. Kappes +8 more
doaj +2 more sources
BCM-7: Opioid-like Peptide with Potential Role in Disease Mechanisms [PDF]
MoleculesBovine milk is an essential supplement due to its rich energy- and nutrient-rich qualities. Caseins constitute the vast majority of the proteins in milk.
Ecem Bolat +8 more
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