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Influence of the β-Casein Genotype of Cow’s Milk (A1, A2) on the Quality and β-Casomorphin-7 (BCM-7) Content of a Semi-Hard Cheese During Production

Foods
Cow’s milk contains A1- and A2-β-caseins. The breakdown of A1-β-casein produces β-casomorphin-7 (BCM-7), a peptide with opioid-like properties that is associated with health aspects.
Benedikt Cramer, Madeleine Ploetz, Carsten Krischek   +2 more
exaly   +7 more sources

BCM-7: Opioid-like Peptide with Potential Role in Disease Mechanisms

Molecules
Bovine milk is an essential supplement due to its rich energy- and nutrient-rich qualities. Caseins constitute the vast majority of the proteins in milk.
Ecem Bolat, Furkan Eker, Selin Yılmaz, Sercan Karav, Emel Oz, Charles Brennan, Charalampos Proestos, Maomao Zeng, Fatih Oz   +8 more
doaj   +10 more sources

A2 Milk and BCM-7 Peptide as Emerging Parameters of Milk Quality

Frontiers in Nutrition, 2022
Beta-casein makes up about 30% of the total protein contained in milk and can be present in cows' milk in two distinct forms (A1 or A2) or as a combination of the two.
Marzia Giribaldi, Cristina Lamberti, Simona Cirrincione, Maria Gabriella Giuffrida, Laura Cavallarin   +4 more
doaj   +6 more sources

Difficulties in Establishing the Adverse Effects of β-Casomorphin-7 Released from β-Casein Variants—A Review

Foods, 2023
β-Casomorphin-7 (BCM-7) is a peptide released through the proteolysis of β-casein (β-CN), which is considered a bioactive peptide displaying evidence of promoting the binding and activation of the μ-opioid receptor located in various body parts, such as ...
Marta Liliane de Vasconcelos, Luisa Maria F. S. Oliveira, Jeremy Paul Hill, Ana Maria Centola Vidal   +3 more
doaj   +2 more sources

Worldwide research on the health effects of bovine milk containing A1 and A2 β-casein: Unraveling the current scenario and future trends through bibliometrics and text mining

Current Research in Food Science, 2023
The possible adverse effect of consuming bovine milk with A1 β-casein (but not with A2 β-casein) on health aspects due to the release of β-casomorphin-7 (BCM-7) is currently under debate.
Jhony Alberto Gonzales-Malca, Vicente Amirpasha Tirado-Kulieva, María Santos Abanto-López, William Lorenzo Aldana-Juárez, Claudia Mabel Palacios-Zapata   +4 more
doaj   +2 more sources

Non-SELEX method for aptamer selection against β-casomorphin-7 peptide

Journal of Dairy Science, 2022
: The non-systematic evolution of ligands by the exponential enrichment (non-SELEX) method was used in the present study for the selection of β-casomorphin-7 (BCM-7)-specific aptamers.
Abhishek Parashar, Vanya Bhushan, Nimai Charan Mahanandia, Sudarshan Kumar, Ashok Kumar Mohanty   +4 more
doaj   +2 more sources

Worldwide Research Trends on Milk Containing Only A2 β-Casein: A Bibliometric Study

Animals, 2022
The protein fraction of β-casein may play a key role in the manifestation of a new intolerance: milk protein intolerance. The most common forms of β-casein among dairy cattle breeds are A1 and A2 β-casein. During gastrointestinal digestion of A1 β-casein,
Lucía Jiménez-Montenegro, Leopoldo Alfonso, José A. Mendizabal, Olaia Urrutia   +3 more
doaj   +2 more sources

Brazilian consumers’ perception of knowledge regarding the presence of the β-casein polymorphism in milk [PDF]

Ciência Rural
: A2 milk contains the A2 β-casein protein, which does not release the opioid peptide β-casomorphin-7 (BCM-7) during digestion. However, there is limited knowledge among Brazilian consumers regarding the concept, characteristics, benefits, and market ...
Renata Delgado Teixeira, Isabella Maciel Costa, Taynan Jonatha Neves Costa, Diego Sartori, Larissa Mirelle Mendes Magalhães, Mariana Batista Magalhães, Gabriel Augusto Marques Rossi, Carolina Colombelli Pacca Mazaro, Bruna Maria Salotti-Souza   +8 more
doaj   +2 more sources

Effects of A1 Milk, A2 Milk and the Opioid-like Peptide β-Casomorphin-7 on the Proliferation of Human Peripheral Blood Mononuclear Cells

Biomolecules
Special attention is given to cow’s milk and its variants, with ongoing discussions about health-related impacts primarily focusing on the A1 variant in contrast to the A2 variant.
Felix Gard, Lili M. Flad, Tanja Weißer, Hermann Ammer, Cornelia A. Deeg   +4 more
doaj   +2 more sources

β-Casomorphin-7 as a Potential Inflammatory Marker: How β-Casomorphin-7 Induces Endothelial Dysfunction in HUVEC/TERT2 Cell Lines

Biomedicines
Background/Objectives: Endothelial dysfunction plays a central role in the development of cardiovascular diseases. β-Casomorphin-7 (BCM-7), a biologically active peptide generated during the digestion of A1 β-casein, is presumed to contribute to this ...
Judit Rita Homoki, Emese Szilágyi-Tolnai, Ildikó Kovács-Forgács, Georgina Pesti-Asbóth, Arnold Markovics, Attila Biró, Péter Dávid, János Lukács, László Stündl, Judit Remenyik, Attila Péter Kiss   +10 more
doaj   +2 more sources