Results 141 to 150 of about 29,567 (180)

Essential thrombocythemia with BCR/ABL rearrangement

Cancer Genetics and Cytogenetics, 1996
Essential thrombocythemia (ET) was diagnosed clinically in three patients Karyotypic analysis and reverse transcription polymerase chain reaction for the bcr-abl chimeric transcript showed that two were Philadelphia chromosome (Ph) positive, bcr-abl positive, whereas the third was Ph negative, bcr-abl positive.
Kwong, YL, Chiu, EKW, Liang, RHS, Chan, V, Chan, TK   +4 more
openaire   +4 more sources

Wrapping BCR-ABL: it's in the bag

Blood, 2010
Abstract Leukemia, with its origin in a specific genetic abnormality, will only arise if the cell properly folds and processes the oncogenic protein encoded by the mutant gene. In this issue of Blood, Tsukahara and Maru describe a set of proteins that control the processing of the nascent BCR-ABL oncoprotein, providing new avenues for ...
Junia V, Melo, Duncan R, Hewett
openaire   +2 more sources

Mechanisms of Transformation by the BCR/ABL Oncogene

International Journal of Hematology, 2001
The Philadelphia chromosome generates a chimeric oncogene in which the BCR and c-ABL genes are fused. The product of this oncogene, BCR/ABL, has elevated ABL tyrosine kinase activity, relocates to the cytoskeleton, and phosphorylates multiple cellular substrates.
M, Sattler, J D, Griffin
openaire   +2 more sources

Response: too much BCR-ABL to live on, but too little BCR-ABL to die on?

Blood, 2012
The mechanistic understanding of persistence of leukemic stem cells during tyrosine kinase inhibitor therapy is an important unmet prerequisite for targeting residual CML and eradicating the disease.
Andreas Burchert, Andreas Neubauer, Andreas Hochhaus   +2 more
openaire   +1 more source

Targeting of BCR-ABL: Lessons learned from BCR-ABL inhibition.

Cellular and molecular biology (Noisy-le-Grand, France), 2017
In 1960 researchers reported that balanced translocation between chromosomes 22 and 9 resulted in the generation of Philadelphia chromosome. This breakthrough revolutionized our knowledge related to leukemia biology and contemporary studies revealed that chromosomal translocation resulted in the fusion between the 5' segment of BCR gene and 3' segment ...
X, Lin, M Z, Qureshi, R, Attar, S, Khalid, F, Tahir, A, Yaqub, A, Aslam, I, Yaylim, L K, De Carlos Back, A A, Farooqi, M, Ismail   +10 more
openaire   +1 more source

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2019
???????????????????????? 3???8 ?????????????? ???????????????????? ???????? bcr/abl ?????????????????? ?????????????? ?????????????? ??'?????????? ???????????? (108 ??????????????????????) ?? ?????????????? ???? ?????????????? ?????????????????????????? ???????????? ?? ???????????????? ?? ?????????????? M-bcr. ???????????????????????????? ???????? ?????
openaire   +3 more sources

The Role of MYC in Transformation by BCR-ABL

Leukemia & Lymphoma, 1993
The BCR-ABL gene plays a central role in the pathogenesis of chronic myelogenous leukemia. Despite a detailed understanding of the regions of BCR and ABL required for transformation by BCR-ABL, little is known about the signalling pathway by which BCR-ABL causes transformation. The nuclear oncogene c-myc plays a critical role in BCR-ABL transformation.
openaire   +2 more sources

Malignant transformation by abl and BCR/ABL

1993
Activated abl oncogenes have been implicated in causing pre-B lymphoma in mice via Abelson murine leukemia virus, fibrosarcoma in cats via Hardy-Zuckerman feline sarcoma virus II, and, through the Philadelphia chromosome, are linked with the myeloproliferative syndrome chronic myelogenous leukemia and with acute lymphoid and myeloid leukemia in humans.
openaire   +2 more sources

The chimeric BCR-ABL gene.

Bailliere's clinical haematology, 1997
The 1982 discovery that in chronic myeloid leukaemia (CML) the ABL proto-oncogene is translocated to the BCR gene located on chromosome 22 initiated many studies on the structural organization and function of these genes. The nucleotide sequence of the entire BCR and major parts of the ABL gene has now been determined.
J, Groffen, N, Heisterkamp
openaire   +1 more source

bcr—abl

Current Opinion in Oncology, 1992
openaire   +1 more source