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Langerhans Cell Histiocytosis Associated With Chronic Myeloid Leukemia: A Pediatric Case Report. [PDF]
Cancer Rep (Hoboken)Latifi A, Yousefian S.
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Targeting Mitochondrial Vulnerabilities in Chronic Myeloid Leukemia: From Pathobiology to Novel Therapeutic Opportunities. [PDF]
Cancers (Basel)Caprino F +8 more
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Pterostilbene downregulates BCR/ABL and induces apoptosis of T315I-mutated BCR/ABL-positive leukemic cellsopenaire
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Dasatinib induces autophagy in mice with Bcr-Abl-positive leukemia
International Journal of Hematology, 2016Dasatinib, a second-generation tyrosine kinase inhibitor, is a highly effective treatment for Bcr-Abl-positive leukemia. However, the mechanism by which dasatinib induces cell death is unclear, particularly in vivo. Autophagy is a lysosomal degradation mechanism essential for cell survival and differentiation.
Makiko, Morita +8 more
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Taxodione induces apoptosis in BCR-ABL-positive cells through ROS generation
Biochemical Pharmacology, 2018Chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL) are hematopoietic malignancies caused by the constitutive activation of BCR-ABL tyrosine kinase. Although direct BCR-ABL inhibitors, such as imatinib, were initially successful in the treatment of leukemia, many patients developed drug resistance over time due to the gatekeeper ...
Yuki, Uchihara +6 more
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ABL-BCR expression in BCR-ABL-positive human leukemia cell lines
Leukemia Research, 1999Expression of normal ABL and BCR and of reciprocal fusion genes BCR-ABL and ABL-BCR was examined in a panel of 53 BCR-ABL-positive cell lines by RT-PCR to determine the influence of the various transcripts on leukemogenesis. Seventeen out of 18 lymphoid cell lines expressed ABL1a and/or ABL1b, whereas only 16 out of 35 myeloid cell lines expressed one ...
Cord C Uphoff +2 more
exaly +3 more sources
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells
Nature Medicine, 1996Brian J Druker +2 more
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The Tyrosine Kinase Inhibitor CGP57148B Selectively Inhibits the Growth of BCR-ABL–Positive Cells
Blood, 1997 Michael W N Deininger +2 more
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BCR-ABL-positive acute myeloid leukemia: a new entity? Analysis of clinical and molecular features
Annals of Hematology, 2016Thomas Burmeister +2 more
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