Results 121 to 130 of about 288,388 (279)

Evaluation of Morpholino Antisense Oligos’ Role on BCR-ABL Gene Silencing in the K562 Cell Line [PDF]

Cell Journal, 2010
Objective: Chronic myeloid leukemia (CML) develops when a hematopoietic stem cellacquires the BCR/ABL fusion gene. This causes these transformed hematopoietic cellsto have a greater than normal proliferation rate.
Bahman Delalat, Soraya Rasi Ghaemi, Saeid Abroun, Mehrdad Noruzinia, Mahmoud Haririan, Masoud Soleimani, Saeid Kaviani   +6 more
doaj  

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Novel Laboratory Approaches in Heavy Chain Disease With Discordant Immunoglobulin Quantitation: A Case Report and Literature Review

Journal of Clinical Laboratory Analysis, EarlyView.
In this study, we investigated a rare case of γ‐heavy chain disease (γ‐HCD) through an integrated laboratory approach. Routine protein analyses (serum protein electrophoresis, immunotyping, and serum/urine immunofixation) identified an IgG monoclonal component without detectable light chains.
Eleonora Longhi, Artan Çeka, Fabiola Olivieri, Marco Moretti, Jacopo Sabbatinelli   +4 more
wiley   +1 more source

Diagnosis and management of biochemical recurrence in patients with prostate cancer who received definitive treatment

Urology Research and Practice, 2019
After definitive treatment, recurrence is seen in some patients, as manifested by a rise in prostate-specific antigen (PSA) before clinical progression.
Hasan Soydan, Kadir Baykal
doaj   +2 more sources

Learning in radiation oncology: 12‐month experience with a new incident learning system

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 63-73, March 2025.
Introduction of an incident learning incident (ILS) was shown to have had a positive impact on reporting and safety culture within a local health district (LHD). Survey findings correlate with existing literature that ILSs are effective tools for improving patient safety and departmental safety facilitating quality improvement.
Krystle Crouch, Laura Adamson, Rachael Beldham‐Collins, Jonathan Sykes, David Thwaites   +4 more
wiley   +1 more source

Robust Object-Based Watermarking Using SURF Feature Matching and DFT Domain [PDF]

, 2013
In this paper we propose a robust object-based watermarking method, in which the watermark is embedded into the middle frequencies band of the Discrete Fourier Transform (DFT) magnitude of the selected object region, altogether with the Speeded Up Robust
Cedillo-Hernandez, M., Garcia-Ugalde, F., Nakano-Miyatake, M., Perez-Meana, H.   +3 more
core   +1 more source

Comparison of Auto‐Contouring Tools for Delineation of Normal Organs at Risk in Paediatric Patients Undergoing Radiotherapy

Journal of Medical Radiation Sciences, EarlyView.
Contouring organs at risk (OARs) manually in paediatric patients undergoing cranial‐spinal radiation therapy (CSI) is a time‐consuming, labour‐intensive task. This study aims to assess the accuracy and clinical acceptability of auto‐contours produced by the Siemens DirectORGANS auto‐contouring software on paediatric patients receiving CSI treatment ...
Isabel Cant, Jonathan Sykes, Yolanda Surjan, Rachael Beldham‐Collins, Laura Murphy, John Fernandez, Alison Salkeld   +6 more
wiley   +1 more source

Fat Mass and Obesity‐Associated Protein Contributes to Tumorigenesis and Drug Resistance of Diffuse Large B‐Cell Lymphoma by Suppressing N6‐Methyladenosine Methylation of Myc

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ibrutinib resistance remains a major obstacle in the treatment of diffuse large B‐cell lymphoma (DLBCL). Fat mass and obesity‐associated protein (FTO) has been implicated in drug resistance through its regulation of N6‐methyladenosine (m6A) modifications; however, whether FTO mediates ibrutinib resistance in DLBCL remains unclear.
Ting‐Ting Lu, Jin‐Hao Chen, Yan‐Fang Wang, Xiao Wu, Hui‐Yun Ni, Qiu‐Rong Zhang   +5 more
wiley   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Efficacy of functional alignment in total knee arthroplasty in restoring in vivo cruciate ligament forces and knee kinematics compared with mechanical alignment

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose The impact of coronal alignment on cruciate ligament forces in bicruciate‐retaining total knee arthroplasty (TKA) remains unclear. We aimed to clarify in vivo cruciate ligament forces and knee kinematics among mechanically aligned (MA) and functionally aligned (FA) TKAs and normal knees.
Kenichi Kono, Hiroshi Inui, Tomofumi Kage, Takaharu Yamazaki, Shuji Taketomi, Darryl D'Lima, Tetsuya Tomita, Sakae Tanaka   +7 more
wiley   +1 more source