Results 21 to 30 of about 109,902 (263)

BCR/ABL1 and BCR are under the transcriptional control of the MYC oncogene [PDF]

Molecular Cancer, 2015
Chronic Myeloid Leukaemia (CML) is caused by the BCR/ABL1 fusion gene. Both the presence and the levels of BCR/ABL1 expression seem to be critical for CML progression from chronic phase (CP) to blast crisis (BC). After the oncogenic translocation, the BCR/ABL1 gene is under the transcriptional control of BCR promoter but the molecular mechanisms ...
SHARMA, NITESH DEVINARAYAN, MAGISTRONI, VERA, PIAZZA, ROCCO GIOVANNI, CITTERIO, STEFANIA, Mezzatesta, C, KHANDELWAL, PRAVEEN, Pirola, A, GAMBACORTI PASSERINI, CARLO   +7 more
openaire   +3 more sources

Suppression of USP7 induces BCR-ABL degradation and chronic myelogenous leukemia cell apoptosis

Cell Death and Disease, 2021
Chronic myelogenous leukemia (CML) is a clonal malignancy of hematopoietic stem cells featured with the fusion protein kinase BCR-ABL. To elicit the mechanism underlying BCR-ABL stability, we perform a screen against a panel of deubiquitinating enzymes ...
Shuoyi Jiang, Xiaoge Wang, Yuanming He, Hongbiao Huang, Biyin Cao, Zubin Zhang, Jinbao Liu, Qi Wang, Zhenqian Huang, Xinliang Mao   +9 more
doaj   +1 more source

Bcr/Abl associated leukemogenesis in bcr null mutant mice [PDF]

Oncogene, 1998
The BCR gene contributes to Philadelphia-positive leukemogenesis via a number of discrete mechanisms, one of which may be through interaction of its normal gene product with the Bcr/Abl oncoprotein. In the current study this hypothesis was tested in vivo by introducing a Bcr/Abl P190 transgene into mice lacking endogenous bcr protein. Our finding, that
J W, Voncken, V, Kaartinen, J, Groffen, N, Heisterkamp   +3 more
openaire   +2 more sources

Augmented B lymphocyte response to antigen in the absence of antigen-induced B lymphocyte signaling in an IgG-transgenic mouse line. [PDF]

PLoS ONE, 2010
IgG-containing B cell antigen receptor (IgG-BCR), the BCR mostly expressed on memory B cells, contains a distinct signaling function from IgM-BCR or IgD-BCR expressed on naïve B cells.
Rong-Yong Man, Taishi Onodera, Emi Komatsu, Takeshi Tsubata   +3 more
doaj   +1 more source

Impact of the Breakpoint Region on the Leukemogenic Potential and the TKI Responsiveness of Atypical BCR-ABL1 Transcripts

Frontiers in Pharmacology, 2021
Chronic Myeloid Leukemia (CML) is a hematological disorder characterized by the clonal expansion of a hematopoietic stem cell carrying the Philadelphia chromosome that juxtaposes the BCR and ABL1 genes.
Michele Massimino, Michele Massimino, Elena Tirrò, Elena Tirrò, Stefania Stella, Stefania Stella, Livia Manzella, Livia Manzella, Maria Stella Pennisi, Maria Stella Pennisi, Chiara Romano, Chiara Romano, Silvia Rita Vitale, Silvia Rita Vitale, Adriana Puma, Adriana Puma, Cristina Tomarchio, Cristina Tomarchio, Sandra Di Gregorio, Sandra Di Gregorio, Agostino Antolino, Francesco Di Raimondo, Francesco Di Raimondo, Paolo Vigneri, Paolo Vigneri   +24 more
doaj   +1 more source

Effect of Bcr sequences on the cellular function of the Bcr-Abl oncoprotein [PDF]

Oncogene, 1997
In Philadelphia chromosome (Ph1)-positive human leukemia, the c-Abl tyrosine kinase is activated by fusion to sequences encoded by the breakpoint cluster region (bcr) gene. Two major types of Bcr-Abl fusion proteins have been found in human leukemia. Fusion of the N-terminal 426 amino acids of Bcr generates p190(Bcr-Abl) which is mostly found in acute ...
J R, McWhirter, J Y, Wang
openaire   +2 more sources

The functional interplay between the t(9;22)-associated fusion proteins BCR/ABL and ABL/BCR in Philadelphia chromosome-positive acute lymphatic leukemia. [PDF]

PLoS Genetics, 2015
The hallmark of Philadelphia chromosome positive (Ph(+)) leukemia is the BCR/ABL kinase, which is successfully targeted by selective ATP competitors. However, inhibition of BCR/ABL alone is unable to eradicate Ph(+) leukemia.
Anahita Rafiei, Afsar Ali Mian, Claudia Döring, Anna Metodieva, Claudia Oancea, Frederic B Thalheimer, Martin Leo Hansmann, Oliver Gerhard Ottmann, Martin Ruthardt   +8 more
doaj   +1 more source

Reciprocal t(9;22) ABL/BCR fusion proteins: leukemogenic potential and effects on B cell commitment. [PDF]

PLoS ONE, 2009
BACKGROUND:t(9;22) is a balanced translocation, and the chromosome 22 breakpoints (Philadelphia chromosome--Ph+) determine formation of different fusion genes that are associated with either Ph+ acute lymphatic leukemia (Ph+ ALL) or chronic myeloid ...
Xiaomin Zheng, Claudia Oancea, Reinhard Henschler, Malcolm A S Moore, Martin Ruthardt   +4 more
doaj   +1 more source

Bcr: a negative regulator of the Bcr-Abl oncoprotein in leukemia [PDF]

Oncogene, 2002
The fusion of 5' parts of the BCR gene to the ABL gene at the second exon yields several forms of an oncogenic Bcr-Abl oncoprotein observed in several types of Philadelphia chromosome positive leukemia patients. The first exon of the BCR gene is a critical part of this fusion, as the coiled-coil domain at the amino terminal domain of the Bcr protein ...
openaire   +2 more sources

Deconvolution of alpha spectra from air filters applied for measurements of the short-lived radon progeny concentration

Nukleonika, 2017
The paper contains a description of a method for the analysis of the complex alpha spectra generated during the measurement of the activity of filters outside of a vacuum chamber under environmental conditions.
Skubacz Krystian
doaj   +1 more source