Results 21 to 30 of about 290,825 (294)

4C3 Human Monoclonal Antibody: A Proof of Concept for Non-pathogenic Proteinase 3 Anti-neutrophil Cytoplasmic Antibodies in Granulomatosis With Polyangiitis

Frontiers in Immunology, 2020
Granulomatosis with polyangiitis (GPA) is a severe autoimmune vasculitis associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCA) mainly targeting proteinase 3 (PR3), a neutrophilic serine proteinase.
Jérôme Granel, Jérôme Granel, Roxane Lemoine, Eric Morello, Yann Gallais, Julie Mariot, Marion Drapeau, Astrid Musnier, Anne Poupon, Martine Pugnière, Seda Seren, Seda Seren, Dalila Nouar, Valérie Gouilleux-Gruart, Valérie Gouilleux-Gruart, Hervé Watier, Hervé Watier, Brice Korkmaz, Brice Korkmaz, Cyrille Hoarau, Cyrille Hoarau   +20 more
doaj   +1 more source

Tyrosine phosphorylation of P160 BCR by P210 BCR-ABL [PDF]

Blood, 1993
Abstract It is well established that the chimeric BCR-ABL gene formed by joining parts of the BCR and ABL genes plays a key role in the pathogenesis of Philadelphia (Ph) chromosome-positive leukemias. We report that simultaneous expression of P210 BCR-ABL and P160 BCR in simian COS-1 cells yielded stable complexes of these two proteins ...
D, Lu, J, Liu, M, Campbell, J Q, Guo, N, Heisterkamp, J, Groffen, E, Canaani, R, Arlinghaus   +7 more
openaire   +3 more sources

Regulation of B cell fate by chronic activity of the IgE B cell receptor. [PDF]

, 2016
IgE can trigger potent allergic responses, yet the mechanisms regulating IgE production are poorly understood. Here we reveal that IgE+ B cells are constrained by chronic activity of the IgE B cell receptor (BCR).
Allen, Christopher DC, Chen, Xiangjun, Liu, Wanli, Robinson, Marcus J, Smith, Geoffrey A, Taunton, Jack, Yang, Zhiyong   +6 more
core   +1 more source

Management of imatinib-resistant CML patients [PDF]

, 2007
Imatinib has had marked impact on outcomes in chronic myelogenous leukemia (CML) patients for all stages of the disease and is endorsed by international treatment guidelines as the first line option.
Branford S, Burger H, Burgess MR, Cortes J, Crossman LC, Donato NJ, Druker BJ, Gambacorti-Passerini C, Giles F, Hochhaus A, Hughes TP, Iacobucci I, Kantarjian H, Lahaye T, Mahon FX, Melo JV, O'Hare T, Quintas-Cardama A, Rousselot P, Sleijfer S, Soverini S, Weisberg E   +21 more
core   +1 more source

Targeting Bruton Tyrosine Kinase: A novel strategy in the treatment of B-cell lymphomas

Forum of Clinical Oncology, 2017
In normal B-cells, Bruton tyrosine kinase (Btk), a non-receptor tyrosine kinase involved in B-cell receptor (BCR) signalling, is essential for cell survival and maturation. Not surprisingly, Btk is also implicated in the pathogenesis of B-cell lymphomas,
Sklavenitis-Pistofidis R., Koletsa T., Lazaridou A., Goulas A.   +3 more
doaj   +1 more source

Dipeptidylpeptidase IV (CD26) defines leukemic stem cells (LSC) in chronic myeloid leukemia [PDF]

, 2014
Chronic myeloid leukemia (CML) is a stem cell (SC) neoplasm characterized by the BCR/ABL1 oncogene. Although mechanisms of BCR/ABL1-induced transformation are well-defined, little is known about effector-molecules contributing to malignant expansion and ...
Bilban, Martin, Blatt, Katharina, Cerny-Reiterer, Sabine, Herndlhofer, Susanne, Herrmann, Harald, Hoermann, Grego, Holyoake, Tessa L., Mannhalter, Christine, Mayerhofer, Matthias, Rulicke, Thomas, Sadovnik, Irina, Sperr, Wolfgang R., Stefanzl, Gabriele, Streubel, Berthold, Valent, Peter, Willmann, Michael   +15 more
core   +1 more source

Studi Daya Dukung Pondasi Dangkal pada Tanah Gambut dengan Kombinasi Geotekstil dan Grid Bambu

Jurnal Teknik Sipil, 2011
Pembangunan konstruksi di atas tanah gambut mempunyai banyak masalah, diantaranya adalah daya dukung tanah yang rendah dan penurunan yang besar. Penggunaan kombinasi grid bambu dan geotekstil diharapkan akan dapat mengatasi masalah tersebut.
Soewignjo Agus Nugroho
doaj   +1 more source

Impact of the Breakpoint Region on the Leukemogenic Potential and the TKI Responsiveness of Atypical BCR-ABL1 Transcripts

Frontiers in Pharmacology, 2021
Chronic Myeloid Leukemia (CML) is a hematological disorder characterized by the clonal expansion of a hematopoietic stem cell carrying the Philadelphia chromosome that juxtaposes the BCR and ABL1 genes.
Michele Massimino, Michele Massimino, Elena Tirrò, Elena Tirrò, Stefania Stella, Stefania Stella, Livia Manzella, Livia Manzella, Maria Stella Pennisi, Maria Stella Pennisi, Chiara Romano, Chiara Romano, Silvia Rita Vitale, Silvia Rita Vitale, Adriana Puma, Adriana Puma, Cristina Tomarchio, Cristina Tomarchio, Sandra Di Gregorio, Sandra Di Gregorio, Agostino Antolino, Francesco Di Raimondo, Francesco Di Raimondo, Paolo Vigneri, Paolo Vigneri   +24 more
doaj   +1 more source

A Bayesian phylogenetic hidden Markov model for B cell receptor sequence analysis. [PDF]

, 2019
The human body generates a diverse set of high affinity antibodies, the soluble form of B cell receptors (BCRs), that bind to and neutralize invading pathogens.
Dhar, Amrit, Matsen, Frederick A, Minin, Vladimir N, Ralph, Duncan K   +3 more
core   +4 more sources

Rapid and Cost-effective Embryo Culture Technique for Commercial Production of Makapuno Seedlings

CORD, 2011
An embryo cultured Makapuno (ECM) production scheme which is simpler, faster and more low-cost than the current protocol has been developed. With improvements in the ex vitro establishment environment, the cut-off age for in vitro stage of seedlings ...
Osmundo D. Orense
doaj   +1 more source