Results 21 to 30 of about 179,498 (360)

Studi Daya Dukung Pondasi Dangkal pada Tanah Gambut dengan Kombinasi Geotekstil dan Grid Bambu

Jurnal Teknik Sipil, 2011
Pembangunan konstruksi di atas tanah gambut mempunyai banyak masalah, diantaranya adalah daya dukung tanah yang rendah dan penurunan yang besar. Penggunaan kombinasi grid bambu dan geotekstil diharapkan akan dapat mengatasi masalah tersebut.
Soewignjo Agus Nugroho
doaj   +1 more source

Impact of the Breakpoint Region on the Leukemogenic Potential and the TKI Responsiveness of Atypical BCR-ABL1 Transcripts

Frontiers in Pharmacology, 2021
Chronic Myeloid Leukemia (CML) is a hematological disorder characterized by the clonal expansion of a hematopoietic stem cell carrying the Philadelphia chromosome that juxtaposes the BCR and ABL1 genes.
Michele Massimino, Michele Massimino, Elena Tirrò, Elena Tirrò, Stefania Stella, Stefania Stella, Livia Manzella, Livia Manzella, Maria Stella Pennisi, Maria Stella Pennisi, Chiara Romano, Chiara Romano, Silvia Rita Vitale, Silvia Rita Vitale, Adriana Puma, Adriana Puma, Cristina Tomarchio, Cristina Tomarchio, Sandra Di Gregorio, Sandra Di Gregorio, Agostino Antolino, Francesco Di Raimondo, Francesco Di Raimondo, Paolo Vigneri, Paolo Vigneri   +24 more
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BCR/ABL1 and BCR are under the transcriptional control of the MYC oncogene [PDF]

Molecular Cancer, 2015
Chronic Myeloid Leukaemia (CML) is caused by the BCR/ABL1 fusion gene. Both the presence and the levels of BCR/ABL1 expression seem to be critical for CML progression from chronic phase (CP) to blast crisis (BC). After the oncogenic translocation, the BCR/ABL1 gene is under the transcriptional control of BCR promoter but the molecular mechanisms ...
SHARMA, NITESH DEVINARAYAN, MAGISTRONI, VERA, PIAZZA, ROCCO GIOVANNI, CITTERIO, STEFANIA, Mezzatesta, C, KHANDELWAL, PRAVEEN, Pirola, A, GAMBACORTI PASSERINI, CARLO   +7 more
openaire   +3 more sources

Combining the Allosteric Inhibitor Asciminib with Ponatinib Suppresses Emergence of and Restores Efficacy Against Highly Resistant BCR-ABL1 Mutants

Cancer Cell, 2019
SUMMARY BCR-ABL1 point mutation-mediated resistance to tyrosine kinase inhibitor (TKI) therapy in Philadelphia chromosome-positive (Ph+) leukemia is effectively managed with several approved drugs, including ponatinib for BCR-ABL1T315I-mutant disease ...
C. Eide, M. Zabriskie, Samantha L Savage Stevens, Orlando Antelope, N. Vellore, H. Than, Anna Reister Schultz, P. Clair, Amber D Bowler, A. Pomicter, D. Yan, A. Senina, W. Qiang, T. Kelley, P. Szankasi, M. Heinrich, J. Tyner, D. Réa, J. Cayuela, Dong-Wook Kim, C. Tognon, T. O'hare, B. Druker, M. Deininger   +23 more
semanticscholar   +1 more source

Rapid and Cost-effective Embryo Culture Technique for Commercial Production of Makapuno Seedlings

CORD, 2011
An embryo cultured Makapuno (ECM) production scheme which is simpler, faster and more low-cost than the current protocol has been developed. With improvements in the ex vitro establishment environment, the cut-off age for in vitro stage of seedlings ...
Osmundo D. Orense
doaj   +1 more source

Bcr/Abl associated leukemogenesis in bcr null mutant mice [PDF]

Oncogene, 1998
The BCR gene contributes to Philadelphia-positive leukemogenesis via a number of discrete mechanisms, one of which may be through interaction of its normal gene product with the Bcr/Abl oncoprotein. In the current study this hypothesis was tested in vivo by introducing a Bcr/Abl P190 transgene into mice lacking endogenous bcr protein. Our finding, that
J W, Voncken, V, Kaartinen, J, Groffen, N, Heisterkamp   +3 more
openaire   +2 more sources

Suppression of USP7 induces BCR-ABL degradation and chronic myelogenous leukemia cell apoptosis

Cell Death and Disease, 2021
Chronic myelogenous leukemia (CML) is a clonal malignancy of hematopoietic stem cells featured with the fusion protein kinase BCR-ABL. To elicit the mechanism underlying BCR-ABL stability, we perform a screen against a panel of deubiquitinating enzymes ...
Shuoyi Jiang, Xiaoge Wang, Yuanming He, Hongbiao Huang, Biyin Cao, Zubin Zhang, Jinbao Liu, Qi Wang, Zhenqian Huang, Xinliang Mao   +9 more
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Sphagneticola Trilobata (L.) Pruski (Asteraceae) Methanol Extract Induces Apoptosis in Leukemia Cells through Suppression of BCR/ABL

Plants, 2021
We will study the effects of the methanol extract of Sphagneticola trilobata (L.) Pruski (Asteraceae) (MeST) on the growth of leukemia cells that may contain the BCR/ABL gene. This study also clarifies the mechanism of this effect on these cells.
Hoang Thanh Chi, Nguyen Thi Lien Thuong, Bui Thi Kim Ly   +2 more
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Effect of Bcr sequences on the cellular function of the Bcr-Abl oncoprotein [PDF]

Oncogene, 1997
In Philadelphia chromosome (Ph1)-positive human leukemia, the c-Abl tyrosine kinase is activated by fusion to sequences encoded by the breakpoint cluster region (bcr) gene. Two major types of Bcr-Abl fusion proteins have been found in human leukemia. Fusion of the N-terminal 426 amino acids of Bcr generates p190(Bcr-Abl) which is mostly found in acute ...
J R, McWhirter, J Y, Wang
openaire   +2 more sources

Augmented B lymphocyte response to antigen in the absence of antigen-induced B lymphocyte signaling in an IgG-transgenic mouse line. [PDF]

PLoS ONE, 2010
IgG-containing B cell antigen receptor (IgG-BCR), the BCR mostly expressed on memory B cells, contains a distinct signaling function from IgM-BCR or IgD-BCR expressed on naïve B cells.
Rong-Yong Man, Taishi Onodera, Emi Komatsu, Takeshi Tsubata   +3 more
doaj   +1 more source