IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate. [PDF]
, 2018 Naive B cells co-express two BCR isotypes, IgM and IgD, with identical antigen-binding domains but distinct constant regions. IgM but not IgD is downregulated on autoreactive B cells. Because these isotypes are presumed to be redundant, it is unknown how
Brombacher, Frank +5 more
core +3 more sources
Suppression of USP7 induces BCR-ABL degradation and chronic myelogenous leukemia cell apoptosis
Cell Death and Disease, 2021 Chronic myelogenous leukemia (CML) is a clonal malignancy of hematopoietic stem cells featured with the fusion protein kinase BCR-ABL. To elicit the mechanism underlying BCR-ABL stability, we perform a screen against a panel of deubiquitinating enzymes ...
Shuoyi Jiang +9 more
doaj +1 more source
Plants, 2021 We will study the effects of the methanol extract of Sphagneticola trilobata (L.) Pruski (Asteraceae) (MeST) on the growth of leukemia cells that may contain the BCR/ABL gene. This study also clarifies the mechanism of this effect on these cells.
Hoang Thanh Chi +2 more
doaj +1 more source
High-energy neutrino conversion into electron-W pair in magnetic field and its contribution to neutrino absorption [PDF]
, 2002 We calculate the conversion rate of high-energy neutrinos propagating in constant magnetic field into an electron-W pair (nu -> W + e) from the imaginary part of the neutrino self-energy.
A. A. Gvozdev +12 more
core +2 more sources
Augmented B lymphocyte response to antigen in the absence of antigen-induced B lymphocyte signaling in an IgG-transgenic mouse line. [PDF]
PLoS ONE, 2010 IgG-containing B cell antigen receptor (IgG-BCR), the BCR mostly expressed on memory B cells, contains a distinct signaling function from IgM-BCR or IgD-BCR expressed on naïve B cells.
Rong-Yong Man +3 more
doaj +1 more source
Clinical implications of discordant early molecular responses in CML patients treated with imatinib [PDF]
, 2019 A reduction in BCR-ABL1/ABL1IS transcript levels to <10% after 3 months or <1% after 6 months of tyrosine kinase inhibitor therapy are associated with superior clinical outcomes in chronic myeloid leukemia (CML) patients.
Accurso V. +23 more
core +1 more source
The functional interplay between the t(9;22)-associated fusion proteins BCR/ABL and ABL/BCR in Philadelphia chromosome-positive acute lymphatic leukemia. [PDF]
PLoS Genetics, 2015 The hallmark of Philadelphia chromosome positive (Ph(+)) leukemia is the BCR/ABL kinase, which is successfully targeted by selective ATP competitors. However, inhibition of BCR/ABL alone is unable to eradicate Ph(+) leukemia.
Anahita Rafiei +8 more
doaj +1 more source
Cirmtuzumab inhibits Wnt5a-induced Rac1 activation in chronic lymphocytic leukemia treated with ibrutinib. [PDF]
, 2016 Signaling via the B cell receptor (BCR) plays an important role in the pathogenesis and progression of chronic lymphocytic leukemia (CLL). This is underscored by the clinical effectiveness of ibrutinib, an inhibitor of Bruton's tyrosine kinase (BTK) that
Chen, L +9 more
core +1 more source
Differential effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway in acute lymphoblastic leukemia [PDF]
, 2013 Purpose: Aberrant PI3K/AKT/mTOR signaling has been linked to oncogenesis and therapy resistance in various malignancies including leukemias. In Philadelphia chromosome (Ph) positive leukemias, activation of PI3K by dysregulated BCR-ABL tyrosine kinase ...
Badura, Susanne +8 more
core +3 more sources
Manganese and zinc in acidic agricultural soils from Central Spain: Distribution and phytoavailability prediction with chemical extraction tests [PDF]
, 2009 The extractability and distribution of manganese (Mn) and zinc (Zn) were evaluated in acidic agricultural soils from Central Spain. Both single (0.1 M hydrochloride [HCl] and 0.05 M ethylenediaminetetraacetate [EDTA]) and sequential extraction procedures
López Valdivia, Luis Manuel +4 more
core +2 more sources