Results 51 to 60 of about 179,498 (360)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Antibody repertoire sequencing analysis

Acta Biochimica et Biophysica Sinica, 2022
High-throughput sequencing for B cell receptor (BCR) repertoire provides useful insights for the adaptive immune system. With the continuous development of the BCR-seq technology, many efforts have been made to develop methods for analyzing the ever ...
Zhang Senxin, Yang Tiange, Liu Xiaojing, Yang Jiyuan, Zheng Xiaoqi   +4 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Application of the Böhm chamber for reference beta dose measurements and the calibration of personal dosimeters

Nukleonika, 2016
Thermoluminescent dosimeters (TLDs) currently used in personal and area dosimetry are often utilized to measure doses of ionizing radiation in fields with a more complex structure and therefore they should be calibrated in relation to different radiation
Skubacz Krystian
doaj   +1 more source

The FcμR Limits Tonic BCR Signaling by Regulating IgM-BCR Expression

Nature Immunology, 2017
The FcμR receptor for the crystallizable fragment (Fc) of immunoglobulin M (IgM) can function as a cell-surface receptor for secreted IgM on a variety of cell types.
Trang T. T. Nguyen, Kathrin Kläsener, Christa Zürn, P. A. Castillo, I. Brust-Mascher, D. Imai, C. Bevins, Colin Reardon, M. Reth, N. Baumgarth   +9 more
semanticscholar   +1 more source

Decoding Spatial Heterogeneity and Multi‐Omics Regulation with Hierarchical Graph Learning

Advanced Science, EarlyView.
ABSTRACT Recent advances in spatial multi‐omics technologies have enabled the simultaneous profiling of multiple molecular layers within the same tissue slice, providing unprecedented opportunities to investigate tissue spatial organization. However, most existing computational methods identify spatial domains in a purely data‐driven manner, rarely ...
Jiazhou Chen, Jiahui Xie, Yi Liao, Junyu Li, Longqi Liu, Xin Gao, Hongmin Cai   +6 more
wiley   +1 more source

BCR ubiquitination controls BCR-mediated antigen processing and presentation

Blood, 2006
AbstractBCR-mediated antigen processing occurs at immunologically relevant antigen concentrations and hinges on the trafficking of antigen-BCR (Ag-BCR) complexes to class II–containing multivesicular bodies (MVBs) termed MIICs. However, the molecular mechanism underlying the trafficking of Ag-BCR complexes to and within MIICs is not well understood. In
Lisa, Drake, Erica M, McGovern-Brindisi, James R, Drake   +2 more
openaire   +3 more sources

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Validation of a Drosophila model of wild-type and T315I mutated BCR-ABL1 in chronic myeloid leukemia: an effective platform for treatment screening

Haematologica, 2020
Chronic myeloid leukemia (CML) is caused by a balanced chromosomal translocation resulting in the formation of BCR-ABL1 fusion gene encoding a constitutively active BCR-ABL1 tyrosine kinase, which activates multiple signal transduction pathways leading ...
Amani Al Outa, Dana Abubaker, Ali Bazarbachi, Marwan El Sabban, Margret Shirinian, Rihab Nasr   +5 more
doaj   +1 more source

Urinary exosomal microRNA profiling in intermediate-risk prostate cancer

Scientific Reports, 2021
MicroRNAs (miRNAs) of urine exosomes have emerged as biomarkers for urological cancers, owing to their high stability. MiRNAs have been linked to factors associated with aggressive prostate cancer such as biochemical recurrence (BCR) and metastasis.
Mee Young Kim, Hyunwoo Shin, Hyong Woo Moon, Yong Hyun Park, Jaesung Park, Ji Youl Lee   +5 more
doaj   +1 more source