Results 211 to 220 of about 93,782 (262)

KCC2 Dysfunction Mediated by Microglial BDNF/TrkB Signaling Exacerbates Early Post-Stroke Seizure Susceptibility. [PDF]

CNS Neurosci Ther
Zhou J, Wang BH, Yu J, Wang G, Cai J, Yu M, Chen K, Wan L, Liu X, Yang Z, Wang Y, Wang Y.   +11 more
europepmc   +1 more source

Overactive bladder phenotype induced by chronic activation of hypothalamic neuroendocrine stress pathways in rats with no extrinsic behavioral stress applied. [PDF]

Sci Rep
Husain J, Bakhareva A, Pace A, Noterman-Soulinthavong M, Herrera GM, Erdos B.   +5 more
europepmc   +1 more source

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Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF

Nature Neuroscience, 2008
Pro- and mature BDNF activate very different receptors and intracellular pathways, potentially leading to either neuronal death or survival. Here we examined the biochemistry of endogenous BDNF in mouse neurons using sensitive reagents and found that pro-BDNF is rapidly converted intracellularly to mature BDNF, the latter being stored and released by ...
Matsumoto, T., Rauskolb, S., Polack, M., Klose, J., Kolbeck, R., Korte, M., Barde, Y. -A.   +6 more
openaire   +3 more sources

Association of circulating BDNF levels with BDNF rs6265 polymorphism in schizophrenia

Behavioural Brain Research, 2020
Schizophrenia is a severe neuropsychiatric disorder affecting 1% of the world population. Disturbances in neuronal development and synaptic connections are important factors in the pathogenesis of schizophrenia. Brain derived neurotrophic factor (BDNF), a member of the neurotrophin family, plays a critical role in the development of neurons.
Pvsn Kiran, Kumar, Prasenjit, Mitra, Raghumoy, Ghosh, Shailja, Sharma, Naresh, Nebhinani, Praveen, Sharma   +5 more
openaire   +2 more sources

BDNF During Withdrawal

2017
Among the adaptations observed following drugs of abuse consumption, BDNF levels are widely altered in both brain and periphery. In this chapter, we first reviewed these adaptations in preclinical studies, in both juveniles and adult animals. A particular focus was made on protracted withdrawal as incubation is often associated with an increase in ...
H, Geoffroy, F, Noble
openaire   +2 more sources

Steroid hormones and BDNF

Neuroscience, 2013
Brain-derived neurotrophic factor (BDNF) is a neurotrophin abundantly expressed in several areas of the central nervous system (CNS) and is known to induce a lasting potentiation of synaptic efficacy, to enhance specific learning and memory processes.
Pluchino N, Russo M, Santoro AN, LITTA, PIETRO SALVATORE, Cela V, Genazzani AR   +5 more
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BDNF dependence in neuroblastoma

Journal of Neuroscience Research, 2001
AbstractNeuroblastomas are heterogeneous tumors arising from sympathetic precursors in the neural crest. Growth factor stimulation of neuroblastomas promote diverse biological responses (mitogenesis, differentiation, cell death) depending on the particular tumor studied.
X, Feng, H, Jiang, J C, Baik, C, Edgar, F F, Eide   +4 more
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To BDNF or Not to BDNF: That Is the Epileptic Hippocampus

The Neuroscientist, 2005
Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, has drawn much attention as a potential therapeutic target for temporal lobe epilepsy (TLE). TLE seizures are produced by synchronized hyperactivity of neuron populations due to the disruption of a balance between excitatory and inhibitory synaptic transmissions.
Ryuta, Koyama, Yuji, Ikegaya
openaire   +2 more sources