Results 81 to 90 of about 565,406 (340)

Effect of laser-welding parameters on the heat input and weld-bead profile [PDF]

, 2005
Laser butt-welding of medium carbon steel was investigated using CW 1.5 kW CO2 laser. The effect of laser power (1.2 - 1.43 kW), welding speed (30 - 70 cm/min) and focal point position (-2.5 - 0 mm) on the heat input and the weld-bead geometry (i.e ...
A.G. Olabi, Allen, Benyounis, Dawes, Fuerschbach, Gunaraj, Gunaraj, Huang, K.Y. Benyounis, Khuri, Kim, M.S.J. Hashmi, Montgomery, Steen   +13 more
core   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Optimizing submerged arc welding using response surface methodology, regression analysis, and genetic algorithm

Defence Technology, 2018
The weld quality is significantly affected by the weld parameters (arc voltage, welding current, nozzle to plate distance and welding speed) in the submerged arc welding (SAW). Bead-on-plate welds were performed on stainless steel plates by automated SAW
Ajitanshu Vedrtnam, Gyanendra Singh, Ankit Kumar   +2 more
doaj   +1 more source

Self-assembly of carbon-nanotube-based single electron memories

, 2006
We demonstrate wafer-scale integration of single electron memories based on carbon nanotube field effect transistors (cnfets) by a complete self assembly process.
Auvray, Balasubramanian, Collins, Devoret, Dresselhaus, Ellis, Fuhrer, Fulton, Futatsugi, Guo, Kataura, Kim, Kong, Lafarge, Lafarge, Marty, Marty, Marty, Matsumoto, McEuen, Nakazato, Ono, Podzorov, Postma, Roschier, Shimada, Tseng, Tsukagoshi, Woodside   +28 more
core   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Bead-Based Multiplex Analysis. Bead-basierte Multiplexanalyse

Laboratoriums Medizin, 2003
Summary : Current developments in laboratory diagnostics are characterized by an increasing request for the simultaneous determination of complex parameter profiles in immunology or microbiology. At the same time, rapid availability of test results and low total costs for testing are emerging needs for diagnostic laboratories. Test platforms that allow
Gerd Schmitz, Mario Probst, Gregor Rothe
openaire   +3 more sources

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Fabrication and Optimization of Electrospun Polyacrylonitrile Nanofiber for Application in Air Filtration

Salāmat-i kār-i Īrān, 2016
Background and aims: In nanofibrous filters, morphological properties, diameter of fibers and porosity percent of media are the most filtration characteristics. Therefore, the present study aimed to optimize the electrospinning parameters for reaching to
Somayeh Farhang Dehghan, Farideh Golbabaei, Bozorgmehr Maddah, Rasoul Yarahmadi, Asghar Sadigh Zadeh   +4 more
doaj  

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source