Results 101 to 110 of about 614,405 (309)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Ancient Egyptian Sulfur Beads [PDF]
The Ancient Egyptian and Near Eastern Collection at Tokai University (AENET), Japan, contains two unique necklaces made of an opaque yellow substance identified as sulfur through XRF and XRD analysis.
Akiyama, Yasunobu, Yamahana, Kyoko
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Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Part 2 "Introduction" of _Beads from Gablonz._ During the 19th and 20th centuries, Gablonz in northern Bohemia (now Jablonec nad Nisou in the Czech Republic) was a major producer and supplier of glass and ceramic beads to the world market.
Neuwirth, Waltraud, Dubsky, Ann
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Beads as Chronological Indicators in West African Archaeology: A Reexamination [PDF]
, 1989 Drawing primarily on data obtained from recent excavations at Elmina, Ghana, this report examines the potential use of beads as temporal markers in West African archaeology.
DeCorse, Christopher R.
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Beads from Gablonz (full text) [PDF]
During the 19th and 20th centuries, Gablonz in northern Bohemia (now Jablonec nad Nisou in the Czech Republic) was a major producer and supplier of glass and ceramic beads to the world market.
Neuwirth, Waltraud, Dubsky, Ann
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source