Results 231 to 240 of about 263,543 (279)

Pharmacokinetics of tildipirosin in beagle dogs

Journal of Veterinary Pharmacology and Therapeutics, 2017
The objective of this study was to investigate the pharmacokinetic profile of tildipirosin (TD) in 24 beagle dogs following intravenous (i.v.) and intramuscular (i.m.) administration, respectively, at 2, 4, and 6 mg/kg. Plasma samples at certain time points (0–14 days) were collected, and the concentrations of drug were quantified by UPLC‐MS/MS. Plasma
J. Wang, T. Zhao, X. Sun, Y. Liu, J. Zhu, S. Zhang, X. Cao   +6 more
openaire   +2 more sources

Pharmacokinetics of Riluzole in Beagle Dogs

Drug Research, 2018
Abstract Background Riluzole is a benzothiazole anticonvulsant used in the treatment of patients with amyotrophic lateral sclerosis and it is being investigated for clinical use in patients with spinal cord injury. The present study evaluated the pharmacokinetics of riluzole in beagle dogs after oral dose administration.
Ana P L, Perdigão, Natalícia de Jesus, Antunes, Lucas T, Juni, Noedi L, de Freitas, Julio, Rojas-Moscoso, Sílvia V M, Corrêa, Ronaldo C, da Costa, Ronilson A, Moreno, Gustavo D, Mendes, Gilberto, De Nucci   +9 more
openaire   +2 more sources

Granulomatous Leptomeningitis in Beagle Dogs

Veterinary Pathology, 1993
A granulomatous leptomeningitis was seen in seven laboratory Beagle dogs (four males, three females), 14 to 15 months old, that had been used as control or experimental subjects in a toxicologic study. The dogs were clinically normal during the experimental period.
H, Maeda, K, Ozaki, K, Horikiri, I, Narama   +3 more
openaire   +2 more sources

Citrinin mycotoxicosis in beagle dogs

Food and Cosmetics Toxicology, 1974
Abstract Three trials were completed in which young beagle dogs were either fed a citrinin-containing culture of Penicillium citrinum (Trial I) or were administered pure citrinin either ip (Trial II) or orally (Trial III). Dogs fed the fungal culture and those given 20 or 40 mg pure citrinin/kg body weight developed renal disease.
W W, Carlton, G, Sansing, G M, Szczech, J, Tuite   +3 more
openaire   +2 more sources

The frank vectorcardiogram of the beagle dog

Journal of Electrocardiology, 1972
Summary A spatial vectorcardiogram (VCG), employing the Frank reference system, was recorded for 29 normal beagle dogs. The QRS loop was elliptical to ovoid and oriented to the left inferior quadrant in the frontal plane, to the left anterior quadrant in the transverse plane, and to the anterior inferior quadrant in the left sagittal plane. The trace
W N, Bloch, K A, Busch, T R, Lewis
openaire   +2 more sources

Pharmacokinetics of Astragalosideiv in Beagle Dogs

European Journal of Drug Metabolism and Pharmacokinetics, 2007
In this study, the pharmacokinetics of Astragaloside iv (AGS-IV) in Beagle dogs was studied by high performance liquid chromatography (HPLC) coupled with tandem mass spectrometry (MS). The concentrations of the drugs in plasma were determined after i.v. administration of 0.5, 1, 2 mg.kg(-1) AGS-IV and p.o. administration of 10 mg.kg(-1) AGS-IV.
Lingling Zhu
exaly   +3 more sources

Endotoxin shock in the beagle dog

American Journal of Obstetrics and Gynecology, 1979
The hemodynamic and metabolic responses to endotoxemia were assessed in seven splenectomized, chronically instrumented, conscious but lightly sedated beagle dogs. Measurements included: cardiac output (CO), right and left atrial pressures (RAP, LAP), systemic and pulmonary arterial pressures (SAP, PAP), and heart rate (HR).
John A. Morris, John P. O'Grady, Patricia Toapanta, Emily Sandoval, Ashis K. Mandal, Jerry Brown, Jeff Chang, John Bankhead   +7 more
openaire   +3 more sources

The beagle dog and contraceptive steroids

Life Sciences, 1977
Abstract The mandatory use of beagle dogs for chronic toxicological testing of contraceptive steroids has eliminated some useful products from the market, and stopped development of new compounds. Mammary tumour formation in beagle bitches is induced by some progestogens, including progesterone, but not in other laboratory species, such as rodents or
openaire   +2 more sources

Retention of 210Pb in Beagle Dogs

Health Physics, 1973
Abstract Four adult beagle dogs were injected intravenously with 11 to 26 μCi of 210Pb cleared of 210Po. The retention of 210Pb was followed by in vivo gamma-ray counting and by the collection and analysis of excreta. The effective half lives for the slowest time constant component of a four-term exponential sum retention equation was 815 days based ...
openaire   +2 more sources

Composition of beagle dog milk

American Journal of Physiology-Legacy Content, 1960
A statistical study has been made of the composition of the major C-containing compounds taken from beagle dog milk during the 3rd through 5th week of lactation. The mean values are as follows: 26% total solids, 13% fat, 3.3% lactose and 9.8% protein. Total solid content was found to vary with fat content according to the equation: % total solids = 15.
J R, LUICK, H R, PARKER, A C, ANDERSEN
openaire   +2 more sources