Results 241 to 250 of about 263,543 (279)

Chlorthalidone Pharmacodynamics in Beagle Dogs

Journal of Pharmaceutical Sciences, 1985
A pharmacodynamic approach was employed to examine the diuretic effect of chlorthalidone in beagle dogs and to identify parameters necessary for optimization of an oral dosage formulation of this drug. The extensive partitioning of chlorthalidone into erythrocytes was shown to be noninstantaneous, with an in vitro partitioning half-life of 18 min.
T R, MacGregor, J J, Keirns, P R, Farina, K M, Matzek, S T, Horhota, H J, Esber   +5 more
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Intraocular haemorrhage in the Beagle dog

Journal of Small Animal Practice, 1973
ABSTRACTVitreous haemorrhage is described in the Beagle dog.Résumé. On décrit une hémorragie vitreuse chez le Briquet.Zusammenfassung. Glasartige Blutung ist im kleinen Spürhund beschrieben.
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Toxicity of Toxaphene in the Rat and Beagle Dog

Toxicological Sciences, 1986
Residues of the insecticidal mixture, toxaphene, have been found in Great Lakes fish. The purpose of the present study was to assess the subchronic toxicity of toxaphene in the rat and beagle dog. In the rat study, groups of 10 male and 10 female animals were fed diets containing 0, 4, 20, 100, or 500 ppm of the test compound for 13 weeks.
I, Chu, D C, Villeneuve, C W, Sun, V, Secours, B, Procter, E, Arnold, D, Clegg, L, Reynolds, V E, Valli   +8 more
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Intraocular pressures in the Beagle dog

Journal of Small Animal Practice, 1971
ABSTRACTUsing a Schiotz tonometer, measurements of intraocular pressure were made on 128 conscious Beagles of 5–36 months and on twelve anaesthetized Beagles aged 3–5 years. The normal range of pressures was between 10 and 31 mm Hg; up to 3 years no significant age or sex differences were found.Résumé. L'auteur a mesuré à l'aide d'un tonomètre Schiotz
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Cataracts in beagle dogs given diazoxide

Diabetes, 1975
In two studies for toxicity, cataracts occurred in beagle dogs given diazoxide daily in high doses. Two of eighteen dogs given diazoxide intravenously at doses of 30.0 mg. per kilogram twice a day for fourteen days had reversible lenticular changes. These changes were not observed in dogs given 22.5 or 10.0 mg. per kilogram twice a day.
D M, Schiavo, W E, Field, F J, Vymetal
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Juvenile cataracts in the Beagle dog

Journal of Small Animal Practice, 1971
ABSTRACTThe form and time of appearance of cataracts in Beagle dogs up to 1 year of age are described; spontaneously occurring cataract is differentiated from drug‐induced lenticular lesions.A cataract is an opacity of the lens, which can be seen using standard ophthal‐moscopic methods.
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Brain Damage in the Epileptic Beagle Dog

Veterinary Pathology, 1983
Brain lesions associated with seizures in an epilepsy-prone colony of beagle dogs were studied in 68 dogs which died as a result of the disorder. Approximately 48.5% of the dogs had a relatively specific pattern of acute brain damage on microscopic examination.
D L, Montgomery, A C, Lee
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Subacute digoxin toxicosis in the beagle dog

Toxicology and Applied Pharmacology, 1976
Abstract Digoxin was administered iv to healthy beagle dogs at dose levels previously shown to induce sustained toxicosis and to permit survival over a 2-week period. Treatment regimens of both 5 and 7 days/week were employed. Electrocardiographic (ECG) responses, clinical pathology, and serum digoxin concentrations were monitored, and, at necropsy ...
R H, Teske, S P, Bishop, H F, Righter, D K, Detweiler   +3 more
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Toxicity of methyl testosterone in the beagle dog

Toxicology, 1977
When methyl testosterone was administered orally to beagle dogs at dosage levels of 2, 4 and 6 mg/kg per day for 27 weeks, hepatotoxicity was induced. The change induced was characterized by enlargement of periportal hepatocytes and the presence of haemosiderin within macrophages. There was some evidence of recovery over a 13-week period.
R, Heywood, H, Chesterman, S A, Ball, P F, Wadsworth   +3 more
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The effects of physostigmine on the electroretinogram in the beagle dog

Veterinary Research Communications, 1995
The purpose of the study was to correlate electroretinogram (ERG) parameters with increasing levels of plasma, erythrocyte and ocular tissue cholinesterase inhibition using the beagle dog as a model for human neurovisual toxicity. The anticholinesterase compound physostigmine was administered at various steady-state intravenous infusion rates based on ...
R D, Jones, B F, Hamilton, P D, Dass
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