Results 41 to 50 of about 1,178,203 (337)

Experimental Study on the Bearing Capacity of Reinforced Concrete Pipes with Corrosion-Thinning Defects Repaired by UHP-ECC Mortar Spraying

open access: yesApplied Sciences, 2023
The in situ spraying method is widely used because of its advantages as a trenchless pipeline repair technology, including a fast construction speed and close bonding between the repair lining layer and the reinforced concrete pipe.
Peng Zhang   +3 more
doaj   +1 more source

Statistical Analysis of Dynamic Bearing Capacity of Driven Pile [PDF]

open access: yes, 2014
This paper presents the use of statistical-probabilistic method in determining pile bearing capacities over a number of driven piles. Four dynamic formulas were employed to estimate pile bearing capacity including modified ENR, Hiley, Navy ???
Arsyad, Ardy, Samang, Lawalenna, Suyadi
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

open access: yesFEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo   +4 more
wiley   +1 more source

A Review-Improvement of Bearing Capacity of Soft Clay by Stone Column Technique [PDF]

open access: yes, 2018
Bearing capacity is the important factor in the construction of buildings. There are many trending methods which are used to improve the bearing capacity of soft clay. One such method is stone column technique.
Narayan, P. P. (P), Ramu, N. (N)
core  

Performance of perforated FRP stub beams subject to static transverse actions [PDF]

open access: yes, 2020
This paper presents an experimental programme designed to investigate the failure mode and ultimate capacity of pultruded glass fibre reinforced polymer (GFRP) cellular profiles subject to transverse loading.
Gand, Alfred   +2 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Experimental investigation of relationship between bearing capacity and vibration parameters for planetary exploration legged rovers

open access: yesROBOMECH Journal, 2023
In recent years, robots with leg mechanisms have received considerable attention as high-running planetary exploration rovers. Rovers undertaking planetary exploration require outstanding running performance to travel on loose ground on which they mostly
Tomohiro Watanabe, Kojiro Iizuka
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

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