Results 81 to 90 of about 1,178,203 (337)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Design and test of a magnetic thrust bearing [PDF]

A magnetic thrust bearing can be employed to take thrust loads in rotating machinery. The design and construction of a prototype magnetic thrust bearing for a high load per weight application is described.
Allaire, P. E., Banerjee, B., Imlach, J., Lewis, D. W., Mikula, A.   +4 more
core   +1 more source

Kajian Pengaruh Jumlah dan Lebar Perkuatan Geotekstil terhadap Daya Dukung Tanah Gambut [PDF]

, 2014
Peat soils have a high compressibily and low bearing capacity. These unfavorable characteristics can cause differential settlement and the construction failure, so that the appropriate improvement methods are required to solve the problems.
Al-Anshori, F. (Fathuddin), Martini, M. (Martini)   +1 more
core  

Superconducting Bearing Design for Outer Rotor Flywheel Using Lumped Parameter Techniques [PDF]

, 2014
This paper describes the application of lumped parameter modeling techniques to designing high temperature superconducting bearings for outer-rotor flywheel energy storage systems.
Chen, D, Longoria, R. G., Hearn, C., Pratap, S. B   +2 more
core   +1 more source

Numerical Simulation of the Bearing Capacity of Variotropic Short Concrete Beams Reinforced with Polymer Composite Reinforcing Bars [PDF]

, 2022
Alexey N. Beskopylny, Besarion Meskhi, Sergey A. Stel’makh, Evgenii M. Shcherban’, Levon R. Mailyan, Andrey Veremeenko, V. S. Akopyan, Aleksandr Shilov, Andrei Chernil’nik, Nikita Beskopylny   +9 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Computer program for flat sector thrust bearing performance [PDF]

A versatile computer program is presented which achieves a rapid, numerical solution of the Reynolds equation for a flat sector thrust pad bearing with either compressible or liquid lubricants.
Etsion, I., Presler, A. F.
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Load-bearing capacity of crane beams with fatigue cracks in the compressed belt zone

, 2021
А. Е. Кубасевич
openalex   +1 more source

Research on the Prediction Method of Ultimate Bearing Capacity of PBL Based on IAGA-BPNN Algorithm [PDF]

, 2020
Yixin Chen, Jianye Zhang, Yongsheng Liu, Siwei Zhao, Shun‐Li Zhou, Jing Chen   +5 more
openalex   +1 more source