The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Measurement of Direct Current Voltage Causing Electrical Pitting
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2010 It is widely known that electrical pitting occurs when an electrical current is passed through a ball or roller bearing. The authors have investigated critical electrical current density causing electrical pitting and have shown that it occurs in a ball ...
Shoji NOGUCHI +2 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
A schistosome [beta] subunit remodels inactivation of a calcium channel _via_ an N-terminal polyacidic motif [PDF]
, 2010 The beta subunit of high voltage-activated Ca (Cav) channels targets the pore forming [alpha]~1~ subunit to the plasma membrane and defines the biophysical phenotype of the Cav channel complex. Cav channel inactivation following activation and opening is
Robert M. Greenberg +1 more
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Magnetic bearing momentum wheels with magnetic gimballing capability for 3-axis active attitude control and energy storage [PDF]
, 1977 Magnetic bearings used for the suspension of momentum wheels provide conclusive advantages: the low friction torques and the absence of abrasion allow the realization of lightweight high speed wheels with high angular momentum and energy storage capacity
Sindlinger, R. S.
core +1 more source
Stiffness and energy losses in cylindrically symmetric superconductor levitating systems
, 2002 Stiffness and hysteretic energy losses are calculated for a magnetically levitating system composed of a type-II superconductor and a permanent magnet when a small vibration is produced in the system.
Alvaro Sanchez +9 more
core +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
ON THE COMPUTATION OF ELECTRICAL RESISTANCE OF HYDRODYNAMIC JOURNAL BEARING [PDF]
Carpathian Journal of Electrical Engineering, 2014 The paper approaches the mathematical model of electrical resistance of hydrodynamic journal bearing under different parameters of operation so as to predict bearing performance and safe load carrying capacity.
Eleonora POP, Gherasim DOMIDE
doaj
Design, Modeling and Control of Magnetic Bearings for a Ring-Type Flywheel Energy Storage System
Energies, 2016 This study is concerned with the magnetic force models of magnetic bearing in a flywheel energy storage system (FESS). The magnetic bearing is of hybrid type, with axial passive magnetic bearing (PMB) and radial hybrid magnetic bearing (HMB). For the PMB,
Chow-Shing Toh, Shyh-Leh Chen
doaj +1 more source