Results 71 to 80 of about 19,374 (297)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
ON THE COMPUTATION OF ELECTRICAL RESISTANCE OF HYDRODYNAMIC JOURNAL BEARING [PDF]
Carpathian Journal of Electrical Engineering, 2014 The paper approaches the mathematical model of electrical resistance of hydrodynamic journal bearing under different parameters of operation so as to predict bearing performance and safe load carrying capacity.
Eleonora POP, Gherasim DOMIDE
doaj
Scaling effects of inverter-induced bearing currents in AC machines
, 2007 In this survey paper, we show by straightforward mathematical scaling considerations that small inverter-fed ac motors of tip to typical 20 kW at 1500/min are likely to suffer from discharge (electric discharge machining) bearing currents, whereas larger
Mütze, A. +5 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Design, Modeling and Control of Magnetic Bearings for a Ring-Type Flywheel Energy Storage System
Energies, 2016 This study is concerned with the magnetic force models of magnetic bearing in a flywheel energy storage system (FESS). The magnetic bearing is of hybrid type, with axial passive magnetic bearing (PMB) and radial hybrid magnetic bearing (HMB). For the PMB,
Chow-Shing Toh, Shyh-Leh Chen
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
LubricantsThis study investigates the effects of harmful bearing currents on the service life of rolling bearings and introduces a model to predict service life as a function of surface roughness. Harmful bearing currents, resulting from electrical discharges, can
Volker Schneider +3 more
doaj +1 more source
Analysis and Control of Slotless Self-Bearing Motor
Actuators, 2019 A self-bearing motor (SBM) is an electric motor with a magnetically integrated bearing function, that is, it can provide levitation and rotation simultaneously as a single actuator.
Huy Phuong Nguyen +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source