Results 81 to 90 of about 898,382 (289)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Bearing Currents in Permanent Magnet Synchronous Machines

, 2011
Diplomityössä on esitelty ja tutkittu laakerivirtailmiötä sähkökoneissa. Työn pääpaino on suurissa kestomagneettitahtikoneissa, joissa niin sanotut kiertävät laakerivirrat ovat dominoivia.
Kanninen, Jarno
core   +1 more source

Rotating gravity currents: small-scale and large-scale laboratory experiments and a geostrophic model [PDF]

, 2007
Laboratory experiments simulating gravity-driven coastal surface currents produced by estuarine fresh-water discharges into the ocean are discussed. The currents are generated inside a rotating tank filled with salt water by the continuous release of ...
Thomas, P. J. (Peter J.), Linden, P. F.
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Design, Modeling and Control of Magnetic Bearings for a Ring-Type Flywheel Energy Storage System

Energies, 2016
This study is concerned with the magnetic force models of magnetic bearing in a flywheel energy storage system (FESS). The magnetic bearing is of hybrid type, with axial passive magnetic bearing (PMB) and radial hybrid magnetic bearing (HMB). For the PMB,
Chow-Shing Toh, Shyh-Leh Chen
doaj   +1 more source

Numerical simulation and experimental study of thrust air bearings with multiple orifices [PDF]

, 2013
http://dx.doi.org/10.1016/j.ijmecsci.2013.03.006The objective of this paper is to provide a numerical simulation and an experimental study in order to assess stiffness and damping characteristics of thrust air bearings with multiple orifices.
A. Ambari, AMBARI, Abdelhak, K. Diop, CHARKI, Abdérafi, S. Champmartin, CHAMPMARTIN, Stephane, A. Charki, DIOP, Khadim   +7 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Effect of Harmful Bearing Currents on the Service Life of Rolling Bearings: From Experimental Investigations to a Predictive Model

Lubricants
This study investigates the effects of harmful bearing currents on the service life of rolling bearings and introduces a model to predict service life as a function of surface roughness. Harmful bearing currents, resulting from electrical discharges, can
Volker Schneider, Marius Krewer, Gerhard Poll, Max Marian   +3 more
doaj   +1 more source

MassFLOW-3D as a simulation tool for turbidity currents [PDF]

, 2014
Turbidity currents are the most important mechanism for the dispersal and deposition of sand in the deep-sea setting and thus the main phenomenon leading to the formation of oil and gas reservoirs in deep water deposits.
Janocko, Michal, Eggenhuisen, Joris T., Sedimentology, RICCARDO BASANI, Howell, J.A., Experiments on turbidity currents in straight channels, channel bends and channel-lobe positions, Wonham, J.P., Hansen, Ernst W.M., JORIS T. EGGENHUISEN, Cartigny, Matthieu J.B., Martinus, A.W., Basani, Riccardo, ERNST W.M. HANSEN, MICHAL JANOCKO, Steel, R.J., MATTHIEU J.B. CARTIGNY, Ravnås, R.   +16 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source