Results 81 to 90 of about 206,251 (288)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

RELATIONSHIP BETWEEN ROLLING AND SLIP RESISTANCE IN ROLLING BEARINGS

Nauka ta progres transportu, 2016
Purpose. About one of the causes of slip rolling is known from the second half of the 19th century, it was believed that the slip resistance appears at the place of contact due to different speeds on the arc of contact.
L. M. Bondarenko, M. O. Babyak, S. O. Yakovlev, S. O. Istin, G. Yu. Moskalev   +4 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Effects of Direct Torque Control Switching Strategies on Common Voltage and Bearing Current [PDF]

Journal of Intelligent Procedures in Electrical Technology, 2012
Bearing current sininduction motorsare considered a sone of the most damaging factors. Induced shaft voltage through the parasitic capacitors cause this type of current.
Mohammad Taghi Sadeghzadeh, Gholam Reza Arab, Amir Hossein Mirzaian, Seyed Mohammad Madani   +3 more
doaj  

Application of a compliant foil bearing for the thrust force estimation in the single stage radial blower

Open Engineering, 2015
The paper presents the application of a compliant foil bearing for estimation of the thrust force in a single stage radial blower under operational conditions. The bump foil of the thrust bearing behaves as a nonlinear spring. The knowledge of the spring
Łagodzinski Jakub, Miazga Kacper, Musiał Izabela   +2 more
doaj   +1 more source

Formation of Corrugated Damage on Bearing Race under Different AC Shaft Voltages

Materials
Corrugated damage to bearings is a common fault in electrical facilities such as new energy vehicles, wind power, and high-speed railways. The aim of this article is to reveal the microscopic characteristics and formation mechanism of such damages. The corrugation with alternating “light” and “dark” shape was produced on GCr15 bearing races in the ...
Zhihao Lou, Chenfei Song, Yulong Ren, Xianjuan Pang, Huanhuan Lu, Sanming Du, Yongzhen Zhang   +6 more
openaire   +2 more sources

Controller arm for a remotely related slave arm [PDF]

, 1979
A segmented controller arm configured and dimensioned to form a miniature kinematic replica of a remotely related slave arm is disclosed. The arm includes: (1) a plurality of joints for affording segments of the arm simultaneous angular displacement ...
Salisbury, J. K., Jr.
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Major challenges in prognostics: study on benchmarking prognostic datasets [PDF]

, 2012
Even though prognostics has been defined to be one of the most difficult tasks in Condition Based Maintenance (CBM), many studies have reported promising results in recent years.
Camci, Faith, Eker, Ömer Faruk, Jennions, Ian K.   +2 more
core  

Accurate Estimation of a Coil Magnetic Dipole Moment

, 2017
In this paper, a technique for accurate estimation of the moment of magnetic dipole is proposed. The achievable accuracy is investigated, as a function of measurement noise affecting estimation of magnetic field cartesian components.
Carbone, Paolo, De Angelis, Alessio, De Angelis, Guido, Dionigi, Marco, Moschitta, Antonio, Santoni, Francesco   +5 more
core   +1 more source