Results 81 to 90 of about 1,122,872 (306)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Persicaria tinctoria Extract Mitigates UV-Associated DNA Damage and Inflammation, While Boosting Vitamin D3 and Melanin in Human Skin

Cosmetics
Benefit/risk management of skin exposure to sunlight, especially ultraviolet (UV) rays, is mainly driven by photoaging, cancer incidence, and the requirement for vitamin D3 synthesis.
Morgane de Tollenaere, Catherine Zanchetta, Anaïs Durduret, Jessy Martinez, Bénédicte Sennelier-Portet, Jean Tiguemounine, Amandine Scandolera, Romain Reynaud   +7 more
doaj   +1 more source

Hidden Beauty in Multiloop Amplitudes [PDF]

, 2006
Planar L-loop maximally helicity violating amplitudes in N = 4 supersymmetric Yang-Mills theory are believed to possess the remarkable property of satisfying iteration relations in L.
Anastasia Volovich, C. Anastasiou, E.I. Buchbinder, F. Cachazo, Freddy Cachazo, J.M. Maldacena, M. Czakon, Marcus Spradlin, V. A. Smirnov, V.A. Smirnov, Z. Bern, Z. Bern   +11 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Modifikasi Penggiling Ayam Berbasis Ergonomi Di UKM Bapak Suman Palembang [PDF]

, 2015
Small medium enterprise (SME) of Mr. Suman in Palembang is a family business which produces meatballs. Meatballs milling results the on sale to small traders and SME it self.
Effendy, Beauty Janiarty
core  

Separation of the Charm and Beauty Production in p--Pb and Pb--Pb Collisions with ALICE

, 2016
Measurements of heavy (charm and beauty) quarks provide useful insights into the properties of the quark--gluon plasma. The good particle identification capabilities of ALICE make a measurement based on the electrons from semi-leptonic decays of heavy ...
Völkl, Martin
core   +1 more source

The analysis of facial beauty: an emerging area of research in pattern analysis [PDF]

, 2010
Much research presented recently supports the idea that the human perception of attractiveness is data-driven and largely irrespective of the perceiver. This suggests using pattern analysis techniques for beauty analysis.
A. Kagian, A.J. O’Toole, B. Fasel, B. Fink, B. Fink, B. Jones, B.W. Baker, C. Darwin, D. Perret, D.P. Barash, E. Holland, F. Galton, H. Gunes, H. Knight, J. Langlois, J. Weeden, J.H. Langlois, J.N. Thakera, J.P. Swaddle, J.S. Winston, K. Dion, K. Grammer, K. Schmid, M. Bashour, M.R. Cunningham, P. Adamson, P. Ekman, R.M. Ricketts, Rankin, T. Lee, T. Leyvand, T. Ozkul, W. Zhao, Y. Eisenthal, Y. Jefferson   +34 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source